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Protein Page:
ERCC2 (human)
rdtyret
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
ERCC2 ATP-dependent 5'-3' DNA helicase, component of the core- TFIIH basal transcription factor. Involved in nucleotide excision repair (NER) of DNA by opening DNA around the damage, and in RNA transcription by RNA polymerase II by anchoring the CDK-activating kinase (CAK) complex, composed of CDK7, cyclin H and MAT1, to the core-TFIIH complex. Involved in the regulation of vitamin-D receptor activity. Might also have a role in aging process and could play a causative role in the generation of skin cancers. Belongs to the helicase family. RAD3/XPD subfamily. One of the six subunits forming the core-TFIIH basal transcription factor which associates with the CAK complex composed of CDK7, CCNH/cyclin H and MNAT1 to form the TFIIH basal transcription factor. The interaction with GTF2H2 results in the stimulation of the 5'-->3' helicase activity. Interacts with Epstein-Barr virus EBNA2. Note: This description may include information from UniProtKB.
Protein type: EC 3.6.4.12; Helicase
Chromosomal Location of Human Ortholog: 19q13.3
Cellular Component: cyclin-dependent protein kinase activating kinase holoenzyme complex; cytoplasm; holo TFIIH complex; nucleoplasm; nucleus; spindle
Molecular Function: 4 iron, 4 sulfur cluster binding; 5'-3' DNA helicase activity; ATP binding; ATP-dependent DNA helicase activity; DNA binding; DNA-dependent ATPase activity; metal ion binding; protein binding; protein C-terminus binding; protein kinase activity; protein N-terminus binding; RNA polymerase subunit kinase activity
Biological Process: aging; apoptosis; bone mineralization; cell proliferation; chromosome segregation; DNA duplex unwinding; DNA repair; embryonic cleavage; erythrocyte maturation; extracellular matrix organization and biogenesis; gene expression; hair cell differentiation; hair follicle maturation; in utero embryonic development; mRNA capping; multicellular organism growth; myelin formation in the central nervous system; negative regulation of gene expression, epigenetic; nucleotide-excision repair; nucleotide-excision repair, DNA incision; positive regulation of DNA binding; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; positive regulation of viral transcription; post-embryonic development; protein amino acid phosphorylation; regulation of gene expression, epigenetic; response to hypoxia; response to oxidative stress; RNA elongation from RNA polymerase I promoter; RNA elongation from RNA polymerase II promoter; spinal cord development; termination of RNA polymerase I transcription; transcription from RNA polymerase I promoter; transcription from RNA polymerase II promoter; transcription initiation from RNA polymerase I promoter; transcription initiation from RNA polymerase II promoter; transcription-coupled nucleotide-excision repair; UV protection; viral reproduction
Disease: Cerebrooculofacioskeletal Syndrome 2; Trichothiodystrophy, Photosensitive; Xeroderma Pigmentosum, Complementation Group D
Reference #:  P18074 (UniProtKB)
Alt. Names/Synonyms: Basic transcription factor 2 80 kDa subunit; BTF2 p80; COFS2; CXPD; DNA excision repair protein ERCC-2; DNA repair protein complementing XP-D cells; EM9; ERCC2; excision repair cross-complementing rodent repair deficiency, complementation group 2; MGC102762; MGC126218; MGC126219; TFIIH 80 kDa subunit; TFIIH basal transcription factor complex 80 kDa subunit; TFIIH basal transcription factor complex helicase subunit; TFIIH p80; TTD; xeroderma pigmentosum complementary group D; Xeroderma pigmentosum group D-complementing protein; XPD; XPDC
Gene Symbols: ERCC2
Molecular weight: 86,909 Da
Basal Isoelectric point: 6.72  Predict pI for various phosphorylation states
CST Pathways:  Protein Acetylation
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

ERCC2

Protein Structure Not Found.


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Modification Sites and Domains  
Click here to view other types of protein modifications

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 K35‑ub LKRTLDAkGHGVLEM
0 1 K96‑ub KLLNFYEkQEGEkLP
0 1 K101‑ub YEkQEGEkLPFLGLA
0 1 K113‑ub GLALSSRkNLCIHPE
0 3 T122‑p LCIHPEVtPLRFGkD
0 1 K128‑ub VtPLRFGkDVDGkCH
0 1 K133‑ub FGkDVDGkCHSLTAS
0 2 Y175 VPLPAGIYNLDDLkA
0 1 K181‑ub IYNLDDLkALGRRQG
0 1 K223‑ub KIADLVSkELARKAV
0 1 T252‑p DSMSVNLtRRTLDRC
0 2 K268‑ub GNLETLQkTVLRIKE
0 1 S296‑p VEGLREAsAARETDA
0 3 K507‑ub DQVAISSkFETREDI
0 1 Y584‑p TSVALEKyQEACENG
0 2 K603‑ub LLSVARGkVSEGIDF
0 1 T653 IRENDFLTFDAMRHA
0 1 K682‑ub GLMVFADkRFARGDK
0 1 K718‑ub DEGVQVAkYFLRQMA
1 0 S737 REDQLGLSLLSLEQL
0 1 K751‑ub LESEETLkRIEQIAQ
  mouse

 
K35 LKRTLDAKGHGVLEM
Q96 KLLSFYEQQEGEKLP
K101 YEQQEGEKLPFLGLA
K113 GLALSSRKNLCIHPE
T122 LCIHPEVTPLRFGKD
K128 VTPLRFGKDVDGKCH
K133 FGKDVDGKCHSLTAS
Y175‑p MPLPAGIyNLDDLKA
K181 IyNLDDLKALGQRQG
K223 KIADLVSKELARKAV
T252 DSMSVNLTRRTLDRC
K268 SNLDTLQKTVLRIKE
S296 VEGLREASVARETDA
K507‑ub DQVAISSkFETREDI
Y584 TSVALEKYQEACENG
K603 LLSVARGKVSEGIDF
T653‑p IRENDFLtFDAMRHA
K682 GLMVFADKRFARADK
K718 DEGVQVAKYFLRQMA
S737‑p REDQLGLsLLSLEQL
Q751 LQSEETLQRIEQIAQ
  rat

 
K35 LKRTLDAKGHGVLEM
Q96 KLLSFYEQQEGEKLP
K101 YEQQEGEKLPFLGLA
K113 GLALSSRKNLCIHPE
T122 LCIHPEVTPLRFGKD
K128 VTPLRFGKDVDGKCH
K133 FGKDVDGKCHSLTAS
Y175 VPLPAGIYNLDDLKA
K181 IYNLDDLKALGQRQG
K223 KIADLVSKELARKAV
T252 DSMSVNLTRRTLDRC
K268 SNLDTLQKTVLRIKE
S296 VEGLREASAARETDA
K507 DQVAISSKFETREDI
Y584 TSVALEKYQEACENG
K603 LLSVARGKVSEGIDF
T653 IRENDFLTFDAMRHA
K682 GLMVFADKRFARADK
K718 DEGVQVAKYFLRQMA
S737 REDQLGLSLLSLEQL
Q751 LQSEETLQRIEQIAQ
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