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Protein Page:
CD40LG (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
CD40LG Mediates B-cell proliferation in the absence of co- stimulus as well as IgE production in the presence of IL-4. Involved in immunoglobulin class switching. Defects in CD40LG are the cause of X-linked immunodeficiency with hyper-IgM type 1 (HIGM1); also known as X-linked hyper IgM syndrome (XHIM). HIGM1 is an immunoglobulin isotype switch defect characterized by elevated concentrations of serum IgM and decreased amounts of all other isotypes. Affected males present at an early age (usually within the first year of life) recurrent bacterial and opportunistic infections, including Pneumocystis carinii pneumonia and intractable diarrhea due to cryptosporidium infection. Despite substitution treatment with intravenous immunoglobulin, the overall prognosis is rather poor, with a death rate of about 10% before adolescence. Belongs to the tumor necrosis factor family. Note: This description may include information from UniProtKB.
Protein type: Cell adhesion; Membrane protein, integral
Chromosomal Location of Human Ortholog: Xq26
Cellular Component: cell surface; external side of plasma membrane; extracellular space; integral to membrane; integral to plasma membrane; intracellular; plasma membrane
Molecular Function: CD40 receptor binding; cytokine activity; protein binding; tumor necrosis factor receptor binding
Biological Process: activation of JNK activity; activation of NF-kappaB transcription factor; B cell differentiation; B cell proliferation; immunoglobulin secretion; inflammatory response; isotype switching; leukocyte adhesion; negative regulation of apoptosis; platelet activation; positive regulation of interleukin-10 production; positive regulation of interleukin-12 production; positive regulation of interleukin-4 production; positive regulation of T cell proliferation; regulation of immune response; regulation of immunoglobulin secretion; T cell costimulation; tumor necrosis factor-mediated signaling pathway
Disease: Immunodeficiency With Hyper-igm, Type 1
Reference #:  P29965 (UniProtKB)
Alt. Names/Synonyms: CD154; CD40 antigen ligand; CD40 ligand; CD40 ligand, membrane form; CD40 ligand, soluble form; CD40-L; CD40L; CD40LG; gp39; hCD40L; HIGM1; IGM; IMD3; T-B cell-activating molecule; T-BAM; T-cell antigen Gp39; TNF-related activation protein; TNFSF5; TRAP; tumor necrosis factor (ligand) superfamily member 5; Tumor necrosis factor ligand superfamily member 5
Gene Symbols: CD40LG
Molecular weight: 29,274 Da
Basal Isoelectric point: 8.53  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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CD40LG

Protein Structure Not Found.
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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 T4‑p ____MIEtyNQTSPR
0 38 Y5‑p ___MIEtyNQTSPRS
0 1 N6 __MIEtyNQTSPRSA
0 1 S78 RCNTGERSLSLLNCE
0 1 S80 NTGERSLSLLNCEEI
0 1 K106 MLNKEETKKENSFEM
0 1 N150 KGYYTMSNNLVTLEN
  mouse

 
T4‑p ____MIEtYsQPSPR
Y5 ___MIEtYsQPSPRS
S6‑p __MIEtYsQPSPRSV
S78‑p RCNKGEGsLsLLNCE
S80‑p NKGEGsLsLLNCEEM
K105 ITLNKEEKKENSFEM
S149‑p KGYYTMKsNLVMLEN
  rat

 
T4 ____MIETYSQPSPR
Y5 ___MIETYSQPSPRS
S6 __MIETYSQPSPRSV
S78 RCNKGEGSLSLLNCE
S80 NKGEGSLSLLNCEEM
K105‑ac ISLNKEEkKEKSFEM
S149 KGYYTMKSNLVVLEN
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