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Protein Page:
ITGA5 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
ITGA5 Integrin alpha-5/beta-1 is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of an heavy and a light chain linked by a disulfide bond. Alpha-5 associates with beta-1. Interacts with HPS5 and NISCH. Interacts with RAB21 and COMP. Interacts with HIV- 1 Tat. Belongs to the integrin alpha chain family. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Membrane protein, integral; Cell adhesion
Chromosomal Location of Human Ortholog: 12q11-q13
Cellular Component: cell surface; focal adhesion; intercellular junction; plasma membrane; ruffle
Molecular Function: platelet-derived growth factor receptor binding; protein binding; vascular endothelial growth factor receptor 2 binding
Biological Process: angiogenesis; cell adhesion; cell-substrate adhesion; extracellular matrix organization and biogenesis; heterotypic cell-cell adhesion; leukocyte migration; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of vascular endothelial growth factor receptor signaling pathway; wound healing, spreading of epidermal cells
Reference #:  P08648 (UniProtKB)
Alt. Names/Synonyms: CD49 antigen-like family member E; CD49e; Fibronectin receptor subunit alpha; fibronectin receptor, alpha subunit; FNRA; Integrin alpha-5; Integrin alpha-5 heavy chain; Integrin alpha-5 light chain; Integrin alpha-F; integrin, alpha 5 (fibronectin receptor, alpha polypeptide); ITA5; ITGA5; very late activation protein 5, alpha subunit; VLA-5; VLA5A
Gene Symbols: ITGA5
Molecular weight: 114,536 Da
Basal Isoelectric point: 5.5  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  GPCR Signaling to MAPKs  |  Growth And Differentiation Control by MAPKs  |  PI3K/Akt Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

ITGA5

Protein Structure Not Found.
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Download ChimeraX Script


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S123‑p KGSRLLEssLsssEG
0 1 S124‑p GSRLLEssLsssEGE
0 2 S126‑p RLLEssLsssEGEEP
0 8 S127‑p LLEssLsssEGEEPV
0 7 S128‑p LEssLsssEGEEPVE
0 1 K137‑ub GEEPVEYkSLQWFGA
0 1 S210‑p GYCQGGFsAEFTKTG
0 1 S394‑p DEFGRFGssLTPLGD
0 1 S395‑p EFGRFGssLTPLGDL
0 1 S595 KIYLRNESEFRDKLS
0 1 S742‑p NPMKAGAsLWGGLRF
0 2 S887‑p LELDPEGsLHHQQKR
0 1 Y1032 FFKRSLPYGTAMEKA
0 1 K1038 PYGTAMEKAQLkPPA
0 1 K1042‑ub AMEKAQLkPPATsDA
0 1 S1047‑p QLkPPATsDA_____
  mouse

 
S126 KGSRILESSLYSAKG
S127 GSRILESSLYSAKGE
Y129 RILESSLYSAKGEEP
S130 ILESSLYSAKGEEPV
A131 LESSLYSAKGEEPVE
K140 GEEPVEYKSLQWFGA
S213 GYCQGGFSAEFTKTG
S397 DEFSRFGSSLTPLGD
S398 EFSRFGSSLTPLGDL
S598‑p KIYLRNEsEFRDKLS
S745 NPMKAGTSLWGGLRF
S891 LELDPETSPHHLQKR
Y1036‑p FFKRSLPyGTAMEkA
K1042‑ub PyGTAMEkAQLKPPA
K1046 AMEkAQLKPPATSDA
S1051 QLKPPATSDA_____
  rat

 
S175 KGSRILESSLYSEEP
S176 GSRILESSLYSEEPV
Y178 RILESSLYSEEPVEY
S179 ILESSLYSEEPVEYK
- gap
K186 SEEPVEYKSLQWFGA
S259 GYCQGGFSAEFTKTG
S443 DEFGRFGSSLTPLGD
S444 EFGRFGSSLTPLGDL
S644 KIYLRNESEFRDKLS
S791 NPMKAGTSIWGGLRF
S937 LELDPEVSPHHLQRR
Y1082 FFKRSLPYGTAMEKA
K1088 PYGTAMEKAQLKPPA
K1092 AMEKAQLKPPATSDA
S1097 QLKPPATSDA_____
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