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Protein Page:
IGF2 (human)

Overview
IGF2 The insulin-like growth factors possess growth-promoting activity. In vitro, they are potent mitogens for cultured cells. IGF-II is influenced by placental lactogen and may play a role in fetal development. Epigenetic changes of DNA hypomethylation in IGF2 are a cause of Silver-Russell syndrome (SRS). A clinically heterogeneous condition characterized by severe intrauterine growth retardation, poor postnatal growth, craniofacial features such as a triangular shaped face and a broad forehead, body asymmetry, and a variety of minor malformations. The phenotypic expression changes during childhood and adolescence, with the facial features and asymmetry usually becoming more subtle with age. Belongs to the insulin family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Secreted, signal peptide; Secreted
Chromosomal Location of Human Ortholog: 11p15.5
Cellular Component: extracellular region; extracellular space; plasma membrane
Molecular Function: growth factor activity; hormone activity; insulin receptor binding; insulin-like growth factor receptor binding; protein binding; protein serine/threonine kinase activator activity; receptor activator activity
Biological Process: cellular protein metabolic process; female pregnancy; genetic imprinting; glucose metabolic process; insulin receptor signaling pathway; memory; multicellular organismal development; negative regulation of natural killer cell mediated cytotoxicity; ossification; platelet degranulation; positive regulation of activated T cell proliferation; positive regulation of catalytic activity; positive regulation of cell proliferation; positive regulation of glycogen biosynthetic process; positive regulation of insulin receptor signaling pathway; positive regulation of MAPKKK cascade; positive regulation of mitosis; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of protein amino acid phosphorylation; positive regulation of protein kinase B signaling cascade; regulation of transcription, DNA-dependent; response to drug; response to estradiol stimulus; response to ethanol; response to nicotine; response to nutrient levels; response to radiation; skeletal development; wound healing
Disease: Beckwith-wiedemann Syndrome; Growth Restriction, Severe, With Distinctive Facies; Silver-russell Syndrome; Wilms Tumor 1
Reference #:  P01344 (UniProtKB)
Alt. Names/Synonyms: C11orf43; FLJ22066; FLJ44734; IGF-II; IGF2; INSIGF; insulin-like growth factor 2; insulin-like growth factor 2 (somatomedin A); Insulin-like growth factor II; Insulin-like growth factor II Ala-25 Del; insulin-like growth factor type 2; pp9974; Preptin; putative insulin-like growth factor II associated protein; somatomedin A; Somatomedin-A
Gene Symbols: IGF2
Molecular weight: 20,140 Da
Basal Isoelectric point: 9.5  Predict pI for various phosphorylation states
Select Structure to View Below

IGF2

Protein Structure Not Found.
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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 - gap
0 2 Y83‑p DLALLETyCATPAKS
0 2 Y116‑p PVGKFFQyDTWKQST
0 2 P172 DPAHGGAPPEMASNR
  mouse

► Hide Isoforms
 
- gap
Y83 DLALLETYCATPAKS
Y116 PVGKFFQYDTWRQSA
S172‑p DPAHGGAsSEMSSNH
  IGF2 iso2  
S4‑p ____MGGsVAGFQVP
Y94 DLALLETYCATPAKS
Y127 PVGKFFQYDTWRQSA
S183 DPAHGGASSEMSSNH
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