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Protein Page:
ABCC2 (human)

Overview
ABCC2 Mediates hepatobiliary excretion of numerous organic anions. May function as a cellular cisplatin transporter. Found on the apical membrane of polarized cells in liver, kidney and intestine. The highest expression is found in liver. Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ABC family
Chromosomal Location of Human Ortholog: 10q24
Cellular Component: apical plasma membrane; cell surface; plasma membrane
Molecular Function: anion transmembrane-transporting ATPase activity; ATPase activity, coupled to transmembrane movement of substances; bilirubin transmembrane transporter activity; protein binding
Biological Process: transmembrane transport; transport
Disease: Dubin-johnson Syndrome
Reference #:  Q92887 (UniProtKB)
Alt. Names/Synonyms: ABC30; ABCC2; ATP-binding cassette sub-family C member 2; ATP-binding cassette, sub-family C (CFTR/MRP), member 2; Canalicular multidrug resistance protein; Canalicular multispecific organic anion transporter 1; CMOAT; CMOAT1; CMRP; DJS; KIAA1010; MRP2; Multidrug resistance-associated protein 2
Gene Symbols: ABCC2
Molecular weight: 174,207 Da
Basal Isoelectric point: 8.57  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

ABCC2

Protein Structure Not Found.


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