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Protein Page:
CBFB (human)

CBFB CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL3 and GM- CSF promoters. CBFB enhances DNA binding by RUNX1. A chromosomal aberration involving CBFB is associated with acute myeloid leukemia of M4EO subtype. Pericentric inversion inv(16)(p13;q22). The inversion produces a fusion protein that consists of the 165 N-terminal residues of CBF-beta (PEPB2) with the tail region of MYH11. Belongs to the CBF-beta family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Oncoprotein; Transcription factor
Chromosomal Location of Human Ortholog: 16q22.1
Cellular Component: membrane
Molecular Function: DNA binding; protein binding; transcription cofactor activity; transcription factor activity
Biological Process: protein polyubiquitination; regulation of transcription from RNA polymerase II promoter; transcription from RNA polymerase II promoter
Reference #:  Q13951 (UniProtKB)
Alt. Names/Synonyms: CBF-beta; CBFB; Core-binding factor subunit beta; core-binding factor, beta subunit; PEA2-beta; PEBB; PEBP2-beta; PEBP2B; polyomavirus enhancer binding protein 2, beta subunit; Polyomavirus enhancer-binding protein 2 beta subunit; SL3-3 enhancer factor 1 beta subunit; SL3-3 enhancer factor 1 subunit beta; SL3/AKV core-binding factor beta subunit
Gene Symbols: CBFB
Molecular weight: 21,508 Da
Basal Isoelectric point: 6.23  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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