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Protein Page:
CENPA (mouse)

Overview
CENPA a basic nuclear protein of the histone H3 family. May act as a core histone necessary for the assembly of centromeres. Contains a histone H3 related histone fold domain that is required for targeting to the centromere. CENPA is proposed to be a component of a modified nucleosome or nucleosome-like structure in which it replaces 1 or both copies of conventional histone H3 in the (H3-H4)2 tetrameric core of the nucleosome particle. Note: This description may include information from UniProtKB.
Protein type: DNA-binding
Cellular Component: chromosome, pericentric region; condensed nuclear chromosome, pericentric region; inner kinetochore of condensed chromosome; nucleosome; nucleus
Molecular Function: centromeric DNA binding; nucleosomal DNA binding
Biological Process: cytokinesis after mitosis; establishment of mitotic spindle orientation; kinetochore assembly; mitotic sister chromatid segregation; nucleosome assembly
Reference #:  O35216 (UniProtKB)
Alt. Names/Synonyms: CENP-A; Cenpa; centromere autoantigen A; Centromere protein A; centrosomin A; Histone H3-like centromeric protein A; OTTMUSP00000025185
Gene Symbols: Cenpa
Molecular weight: 15,509 Da
Basal Isoelectric point: 11.27  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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CENPA

Protein Structure Not Found.
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