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Protein Page:
PTPRM (human)

PTPRM a single-pass type I membrane protein involved in cell-cell adhesion through homophilic interactions. A protein-tyrosine phosphatase receptor of the class 2B subfamily. A negative regulator of proliferation and invasion of breast cancer cells. The PTPRM gene is frequently hypermethylated in sporadic cancers. Modulates p120 catenin phosphorylation, promoting adipogenic differentiation. Two isoforms of the human protein have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Membrane protein, integral; Motility/polarity/chemotaxis; Phosphatase; Receptor protein phosphatase, tyrosine
Chromosomal Location of Human Ortholog: 18p11.2
Cellular Component: cell-cell adherens junction; cytoplasm; intercellular junction; lamellipodium; perinuclear region of cytoplasm
Molecular Function: cadherin binding; protein binding; protein tyrosine phosphatase activity; transmembrane receptor protein tyrosine phosphatase activity
Biological Process: homophilic cell adhesion; negative regulation of angiogenesis; negative regulation of endothelial cell proliferation; neurite development; protein amino acid dephosphorylation; response to drug; retinal ganglion cell axon guidance; signal transduction
Reference #:  P28827 (UniProtKB)
Alt. Names/Synonyms: hR-PTPu; MGC166994; protein tyrosine phosphatase mu; protein tyrosine phosphatase, receptor type, M; protein tyrosine phosphatase, receptor type, mu polypeptide; Protein-tyrosine phosphatase mu; PTPRL1; PTPRM; R-PTP-mu; Receptor-type tyrosine-protein phosphatase mu; RPTPM; RPTPU
Gene Symbols: PTPRM
Molecular weight: 163,682 Da
Basal Isoelectric point: 6.21  Predict pI for various phosphorylation states
CST Pathways:  Adherens Junction Dynamics
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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