a single-pass type I membrane protein involved in cell-cell adhesion through homophilic interactions. A protein-tyrosine phosphatase receptor of the class 2B subfamily. A negative regulator of proliferation and invasion of breast cancer cells. The PTPRM gene is frequently hypermethylated in sporadic cancers. Modulates p120 catenin phosphorylation, promoting adipogenic differentiation. Two isoforms of the human protein have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 220.127.116.11; Membrane protein, integral; Motility/polarity/chemotaxis; Phosphatase; Receptor protein phosphatase, tyrosine