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Protein Page:
JAG2 (human)

Overview
JAG2 Putative Notch ligand involved in the mediation of Notch signaling. Involved in limb development. Expressed in heart, placenta and skeletal muscle and to a lesser extend in pancreas. Very low expression in brain, lung, liver and kidney. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Cell surface
Chromosomal Location of Human Ortholog: 14q32
Cellular Component: integral to plasma membrane; plasma membrane
Molecular Function: calcium ion binding; growth factor activity; Notch binding; protein binding
Biological Process: auditory receptor cell fate commitment; cell cycle; cell differentiation; gamma-delta T cell differentiation; in utero embryonic development; morphogenesis of embryonic epithelium; Notch receptor processing; Notch signaling pathway; odontogenesis of dentine-containing teeth; positive regulation of Notch signaling pathway; regulation of cell adhesion; regulation of cell migration; regulation of cell proliferation; respiratory system process; skeletal development; spermatogenesis; T cell differentiation; thymic T cell selection
Reference #:  Q9Y219 (UniProtKB)
Alt. Names/Synonyms: hJ2; JAG2; jagged 2; Jagged2; Protein jagged-2; SER2
Gene Symbols: JAG2
Molecular weight: 133,367 Da
Basal Isoelectric point: 5.53  Predict pI for various phosphorylation states
CST Pathways:  Notch Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

JAG2

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S35‑p GYFELQLsALRNVNG
0 2 Y202‑p RVRCDENyySATCNK
0 2 Y203‑p VRCDENyySATCNKF
0 1 S1059‑p AITQRGNssLLLAVt
0 1 S1060‑p ITQRGNssLLLAVtE
0 1 T1066‑p ssLLLAVtEVKVETV
0 2 S1123‑p SRLPREEsANNQWAP
0 2 Y1149‑p GGHKDVLyQCKNFtP
0 3 T1155‑p LyQCKNFtPPPRRAD
0 2 S1208‑p FTKDPGRsPGRPAHW
  mouse

 
S35 GYFELQLSALRNVNG
Y202 RVRCDENYYSATCNK
Y203 VRCDENYYSATCNKF
S1061 AITQRGNSSLLLAVT
S1062 ITQRGNSSLLLAVTE
T1068 SSLLLAVTEVKVETV
S1125 SRLPRDESANNQWAP
Y1158 GGHKDILYQCKNFtP
T1164 LYQCKNFTPPPRRAG
S1217 FTKDPSCSLGRPARW
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