an AGC kinase of the PKC family. A classical PKC downstream of many mitogenic and receptors. Classical PKCs are calcium-dependent enzymes that are activated by phosphatidylserine, diacylglycerol and phorbol esters. Contains a pseudo-substrate autoinhibitory domain that binds to the catalytic domain preventing its activation in the absence of cofactors or activators. Note: This description may include information from UniProtKB.
Protein type: EC 18.104.22.168; Oncoprotein; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); AGC group; PKC family; Alpha subfamily
Cellular Component: apical part of cell; cell soma; cytoplasm; cytosol; dendrite; endoplasmic reticulum; mitochondrial membrane; mitochondrion; nucleoplasm; perinuclear region of cytoplasm; photoreceptor outer segment; plasma membrane
Molecular Function: ATP binding; calcium-dependent protein kinase C activity; enzyme binding; protein binding; protein kinase activity; protein kinase C activity; protein serine/threonine kinase activity; zinc ion binding
Biological Process: adenylate cyclase activation; angiogenesis; blood coagulation; cell adhesion; cellular calcium ion homeostasis; chondrocyte differentiation; energy reserve metabolic process; epidermal growth factor receptor signaling pathway; extracellular matrix organization and biogenesis; fibroblast growth factor receptor signaling pathway; gene expression; inactivation of MAPK activity; induction of positive chemotaxis; innate immune response; mitotic cell cycle; mitotic nuclear envelope disassembly; negative regulation of adenylate cyclase activity; negative regulation of cell proliferation; negative regulation of glucose import; negative regulation of insulin receptor signaling pathway; nerve growth factor receptor signaling pathway; neutrophil chemotaxis; peptidyl-serine phosphorylation; phospholipase C activation; phototransduction, visible light; platelet activation; positive regulation of angiogenesis; positive regulation of blood vessel endothelial cell migration; positive regulation of cell adhesion; positive regulation of cell migration; positive regulation of endothelial cell proliferation; positive regulation of inflammatory response; positive regulation of lipopolysaccharide-mediated signaling pathway; positive regulation of macrophage differentiation; positive regulation of mitotic cell cycle; protein amino acid phosphorylation; regulation of insulin secretion; regulation of mRNA stability; regulation of muscle contraction; regulation of peptidyl-tyrosine phosphorylation; regulation of rhodopsin mediated signaling; regulation of the force of heart contraction; rhodopsin mediated signaling; signal transduction; synaptic transmission; vascular endothelial growth factor receptor signaling pathway
LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.