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Protein Page:
Nur77 (human)
rdtyret
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
Nur77 an orphan nuclear receptor and immediate-early gene that regulates cellular proliferation, apoptosis, inflammation, and glucose metabolism. Induced by exercise in muscle and is a functional regulator of glucose metabolism in skeletal muscle. Its level decreases in the muscle of obese insulin-resistant men. Acts concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5'-AAAAGGTCA-3'. May inhibit NF-kappa-B transactivation of IL2. A mediator of TCR-directed thymocyte apoptosis. TCR-signaling induces a FAIM/Akt/Nur77 signaling pathway that is critical for modulating apoptosis in developing thymocytes. A physiological substrate of the MEK-ERK-RSK cascade that modulates nuclear export and intracellular translocation during T cell death. Binds DNA as a monomer. Interacts with GADD45GIP1. Overexpression of Nur77 induces the expression of both p300 and HDAC1. Acetylation by p300 and HDAC1 may regulate the rapid turnover of Nur77 protein. Note: This description may include information from UniProtKB.
Protein type: Nuclear receptor; Apoptosis; DNA-binding
Chromosomal Location of Human Ortholog: 12q13
Cellular Component: cytoplasm; nuclear membrane; nucleoplasm; nucleus
Molecular Function: DNA binding; ligand-dependent nuclear receptor activity; protein binding; protein heterodimerization activity; sequence-specific DNA binding; steroid hormone receptor activity; zinc ion binding
Biological Process: cell migration during sprouting angiogenesis; epidermal growth factor receptor signaling pathway; fat cell differentiation; fibroblast growth factor receptor signaling pathway; gene expression; innate immune response; intracellular receptor-mediated signaling pathway; negative regulation of cell cycle; nerve growth factor receptor signaling pathway; phosphoinositide-mediated signaling; positive regulation of endothelial cell proliferation; positive regulation of transcription from RNA polymerase II promoter; signal transduction; steroid hormone mediated signaling; transcription initiation from RNA polymerase II promoter
Reference #:  P22736 (UniProtKB)
Alt. Names/Synonyms: Early response protein NAK1; GFRP1; growth factor-inducible nuclear protein N10; HMR; hormone receptor; MGC9485; N10; NAK-1; NAK1; NGFIB; NP10; NR4A1; Nuclear receptor subfamily 4 group A member 1; nuclear receptor subfamily 4, group A, member 1; Nur77; Orphan nuclear receptor HMR; Orphan nuclear receptor TR3; ST-59; steroid receptor TR3; Testicular receptor 3; TR3; TR3 orphan receptor
Gene Symbols: NR4A1
Molecular weight: 64,463 Da
Basal Isoelectric point: 6.82  Predict pI for various phosphorylation states
CST Pathways:  Growth And Differentiation Control by MAPKs
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

Nur77

Protein Structure Not Found.


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Sites Implicated In
apoptosis, induced: S351‑p
cell cycle regulation: S95‑p, S140‑p, S431‑p
cell growth, induced: T48‑p, S52‑p, S54‑p, T55‑p, Y60‑p, T61‑p, S351‑p
cell motility, induced: T48‑p, S52‑p, S54‑p, T55‑p, Y60‑p, T61‑p, S351‑p
cytoskeletal reorganization: T48‑p, S52‑p, S54‑p, T55‑p, Y60‑p, T61‑p, S351‑p
transcription, altered: S95‑p
transcription, induced: S431‑p
transcription, inhibited: S351‑p
activity, inhibited: S95‑p, S351‑p
molecular association, regulation: S95‑p, S140‑p, S431‑p
phosphorylation: S351‑p
protein degradation: S95‑p
protein stabilization: S95‑p

Modification Sites and Domains  
Click here to view other types of protein modifications

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 T10‑p CIQAQYGtPAPsPGP
0 1 S14‑p QYGtPAPsPGPRDHL
0 1 S23‑p GPRDHLAsDPLtPEF
0 1 T27‑p HLAsDPLtPEFIKPT
1 0 T48‑p EAAPAAPtALPsFst
1 0 S52‑p AAPtALPsFstFMDG
1 0 S54‑p PtALPsFstFMDGyt
1 0 T55‑p tALPsFstFMDGytG
1 0 Y60‑p FstFMDGytGEFDTF
1 0 T61‑p stFMDGytGEFDTFL
2 0 S95‑p TSSSSATsPASASFK
3 0 S140‑p GSPCSAPsPStPSFQ
2 0 T143‑p CSAPsPStPSFQPPQ
1 0 S152‑p SFQPPQLsPWDGSFG
0 2 S193‑p PPAFFSFsPPtGPSP
0 2 T196‑p FFSFsPPtGPSPsLA
0 1 S201‑p PPtGPSPsLAQsPLK
0 2 S205‑p PSPsLAQsPLKLFPS
0 1 S257‑p VTSTKARsGAPGGsE
0 2 S263‑p RsGAPGGsEGRCAVC
1 1 S341‑p KEVVRTDsLKGRRGR
9 3 S351‑p GRRGRLPsKPKQPPD
0 2 S360‑p PKQPPDAsPANLLTS
0 1 K381‑ub DSGPSTAkLDYSKFQ
0 1 K386 TAkLDYSKFQELVLP
1 0 S431‑p IPGFAELsPADQDLL
5095 : Phospho-Nur77 (Ser351) (D22G5) Rabbit mAb
  mouse

 
T10 CIQAQYGTPATSPGP
S14 QYGTPATSPGPRDHL
G23 GPRDHLTGDPLALEF
A27 HLTGDPLALEFGKPT
A48 ETAPAAPATLPSFST
S52 AAPATLPSFSTFMDG
S54 PATLPSFSTFMDGYT
T55 ATLPSFSTFMDGYTG
Y60 FSTFMDGYTGEFDTF
T61 STFMDGYTGEFDTFL
S97 SSSSSATSPASASFK
S142‑p GSPCSAPsPSTPNFQ
T145 CSAPsPSTPNFQPSQ
S154 NFQPSQLSPWDGSFG
S196 PPTFFSFSPPTGPSP
T199 FFSFSPPTGPSPSLA
S204 PPTGPSPSLAQSSLK
S208 PSPSLAQSSLKLFPP
S260 VTSTKSRSGASGGSE
S266 RSGASGGSEGRCAVC
S344 KEVVRTDSLKGRRGR
S354‑p GRRGRLPsKPKQPPD
S363 PKQPPDASPTNLLTS
K384 DSGPSTAKLDYSkFQ
K389‑ac TAKLDYSkFQELVLP
C434 IPGFIELCPGDQDLL
5095 : Phospho-Nur77 (Ser351) (D22G5) Rabbit mAb
  rat

 
T10 CIQAQYGTPATSPGP
S14 QYGTPATSPGPRDHL
G23 GPRDHLTGDPLALEF
A27 HLTGDPLALEFSKPT
A48 ETAPTAPATLPSFST
S52 TAPATLPSFSTFMDG
S54 PATLPSFSTFMDGGY
T55 ATLPSFSTFMDGGYT
Y61 STFMDGGYTGEFDTF
T62 TFMDGGYTGEFDTFL
S94 SSSSSATSPASASFK
S139 GSPCSAPSPPtPNFQ
T142‑p CSAPSPPtPNFQPSQ
S151 NFQPSQLSPWDGSFG
S192 PPTFFSFSPPTGPSP
T195 FFSFSPPTGPSPSLA
S200 PPTGPSPSLAQSSLK
S204 PSPSLAQSSLKLFPA
S256 VTSTKARSGSSGGSE
S262 RSGSSGGSEGRCAVC
S340‑p KEVVRTDsLKGRRGR
S350‑p GRRGRLPsKPKQPPD
S359 PKQPPDASPTNLLTS
K380 DSGPNTAKLDYSKFQ
K385 TAKLDYSKFQELVLP
S430 IPGFIELSPGDQDLL
5095 : Phospho-Nur77 (Ser351) (D22G5) Rabbit mAb
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