Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteprivacy & cookiesCuration ProcessContact
logos LINCs Logo Mt Sinai Logo NIH Logo NCI Logo
Protein Page:
NRF1 (human)

Overview
NRF1 Transcription factor that activates the expression of the EIF2S1 (EIF2-alpha) gene. Links the transcriptional modulation of key metabolic genes to cellular growth and development. Implicated in the control of nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication. Belongs to the NRF1/Ewg family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 7q32
Cellular Component: nucleoplasm; nucleus
Molecular Function: protein binding; protein homodimerization activity
Biological Process: generation of precursor metabolites and energy; mitochondrion organization and biogenesis; positive regulation of transcription from RNA polymerase II promoter; regulation of transcription from RNA polymerase II promoter
Reference #:  Q16656 (UniProtKB)
Alt. Names/Synonyms: Alpha palindromic-binding protein; Alpha-pal; NRF-1; NRF1; Nuclear respiratory factor 1
Gene Symbols: NRF1
Molecular weight: 53,541 Da
Basal Isoelectric point: 4.94  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

NRF1

Protein Structure Not Found.


STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Scansite  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein