an AGC kinase of the PKC family. A novel PKC: Ca2+ independent but still regulated by PS, DAG and phorbol esters. Contains 2 zinc-dependent phorbol-ester and DAG binding domains. Expressed in skeletal muscle and hematopoietic cells. May play a role in T cell receptor signaling and insulin resistance. Required for TCR-induced NF-kappaB activation in mature T lymphocytes. Note: This description may include information from UniProtKB.
Protein type: Kinase, protein; EC 18.104.22.168; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); AGC group; PKC family; Delta subfamily
Molecular Function: ATP binding; metal ion binding; protein binding; protein kinase activity; protein kinase C activity; protein serine/threonine kinase activity
Biological Process: activation of NF-kappaB transcription factor; aging; axon guidance; cell structure disassembly during apoptosis; inflammatory response; membrane protein ectodomain proteolysis; negative regulation of insulin receptor signaling pathway; peptidyl-serine phosphorylation; platelet activation; positive regulation of filopodium formation; positive regulation of interleukin-17 production; positive regulation of interleukin-2 biosynthetic process; positive regulation of interleukin-4 production; positive regulation of NF-kappaB import into nucleus; positive regulation of protein secretion; positive regulation of stress fiber formation; positive regulation of T cell activation; positive regulation of T cell proliferation; positive regulation of telomerase activity; positive regulation of telomere maintenance via telomerase; regulation of cell growth; regulation of G2/M transition of mitotic cell cycle; regulation of transcription, DNA-dependent; regulation of vasoconstriction; respiratory burst; response to glucose stimulus; response to heat; response to hypoxia; response to insulin stimulus; response to organic cyclic substance; T cell receptor signaling pathway; tissue regeneration
LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.