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Protein Page:
galectin-1 (human)

Overview
galectin-1 May regulate apoptosis, cell proliferation and cell differentiation. Binds beta-galactoside and a wide array of complex carbohydrates. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase. Homodimer. Binds LGALS3BP. Interacts with CD2, CD3, CD4, CD7, CD43 and CD45. Interacts with laminin (via poly-N- acetyllactosamine). Expressed in placenta, maternal decidua and fetal membranes. Within placenta, expressed in trophoblasts, stromal cells, villous endothelium, syncytiotrophoblast apical membrane and villous stroma. Within fetal membranes, expressed in amnion, chorioamniotic mesenchyma and chorion. Expressed in cardiac, smooth, and skeletal muscle, neurons, thymus, kidney and hematopoietic cells. Note: This description may include information from UniProtKB.
Protein type: Cell adhesion; Extracellular matrix; Secreted
Chromosomal Location of Human Ortholog: 22q13.1
Cellular Component: cytoplasm; extracellular matrix; extracellular space; intracellular
Molecular Function: protein binding; signal transducer activity
Biological Process: positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of virion penetration into host cell; regulation of apoptosis
Reference #:  P09382 (UniProtKB)
Alt. Names/Synonyms: 14 kDa laminin-binding protein; 14 kDa lectin; Beta-galactoside-binding lectin L-14-I; DKFZp686E23103; Gal-1; GAL1; Galaptin; galectin 1; Galectin-1; GBP; HBL; HLBP14; HPL; Lactose-binding lectin 1; Lectin galactoside-binding soluble 1; lectin, galactoside-binding, soluble, 1; LEG1; LGALS1; Putative MAPK-activating protein PM12; S-Lac lectin 1
Gene Symbols: LGALS1
Molecular weight: 14,716 Da
Basal Isoelectric point: 5.33  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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galectin-1

Protein Structure Not Found.
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