a dual-specificity protein kinase of the STE7 family. Activates JNK1 and -2 by phosphorylating a Thr and a Tyr residue in the activation loop. Is activated by proinflammatory cytokines and environmental stress. Three alternatively spliced isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, STE; Kinase, protein; EC 184.108.40.206; Protein kinase, dual-specificity (non-receptor); STE group; STE7 family
Cellular Component: cytoplasm; cytosol; nucleus
Molecular Function: ATP binding; enzyme binding; JUN kinase kinase activity; kinase activity; magnesium ion binding; MAP kinase kinase activity; metal ion binding; mitogen-activated protein kinase kinase kinase binding; nucleotide binding; protein binding; protein C-terminus binding; protein kinase activity; protein kinase binding; protein phosphatase binding; protein serine/threonine kinase activity; protein-tyrosine kinase activity; receptor signaling protein serine/threonine kinase activity; transferase activity
Biological Process: activation of JNK activity; apoptosis; JNK cascade; phosphorylation; positive regulation of neuron apoptosis; positive regulation of protein amino acid phosphorylation; positive regulation of telomerase activity; positive regulation of telomere maintenance via telomerase; protein amino acid phosphorylation; response to heat; response to osmotic stress; response to stress; response to UV; response to wounding; stress-activated MAPK cascade
LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.