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Protein Page:
NCBP1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
NCBP1 mediates U snRNA export from the nucleus. Binds to 5' capped mRNA. Found in aU snRNA export complex with RNUXA/PHAX, CBP20, CBP80, RAN, XPO1 and m7G-capped RNA. Interaction with RNUXA/PHAX. Heterodimer with NCBP2. Is part of the exon junction complex (EJC) containing NCBP1, NCBP2, RNPS1, RBM8A, SRRM1, NXF1, UPF3B, UPF2, THOC4 and/or REFBP2. Note: This description may include information from UniProtKB.
Protein type: RNA processing; Spliceosome; Translation
Chromosomal Location of Human Ortholog: 9q34.1
Cellular Component: cytoplasm; cytosol; mitochondrion; mRNA cap complex; nucleoplasm; nucleus; ribonucleoprotein complex
Molecular Function: protein binding; RNA binding
Biological Process: fibroblast growth factor receptor signaling pathway; gene expression; histone mRNA metabolic process; mRNA 3'-end processing; mRNA capping; mRNA catabolic process, nonsense-mediated decay; mRNA export from nucleus; nuclear export; nuclear mRNA splicing, via spliceosome; positive regulation of cell growth; positive regulation of mRNA 3'-end processing; regulation of translational initiation; RNA elongation from RNA polymerase II promoter; RNA export from nucleus; RNA splicing; snRNA transcription from RNA polymerase II promoter; termination of RNA polymerase II transcription; transcription from RNA polymerase II promoter
Reference #:  Q09161 (UniProtKB)
Alt. Names/Synonyms: 80 kDa nuclear cap-binding protein; CBP80; MGC2087; NCBP; NCBP 80 kDa subunit; NCBP1; nuclear cap binding protein subunit 1, 80kDa; Nuclear cap-binding protein subunit 1; Sto1
Gene Symbols: NCBP1
Molecular weight: 91,839 Da
Basal Isoelectric point: 5.99  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

NCBP1

Protein Structure Not Found.
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Sites Implicated In
RNA splicing, altered: S7‑p, T21‑p, S22‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
1 23 S7‑p _MSRRRHsDENDGGQ
0 1 D8 MSRRRHsDENDGGQP
0 1 K17 NDGGQPHKRRKtsDA
1 89 T21‑p QPHKRRKtsDANEtE
1 58 S22‑p PHKRRKtsDANEtED
0 10 T27‑p KtsDANEtEDHLEsL
0 3 S33‑p EtEDHLEsLICKVGE
0 1 K41‑ub LICKVGEkSACSLES
0 1 K117‑ub RQLKESLkANNYNEA
0 1 Y126‑p NNYNEAVyLVRFLSD
0 1 S175‑p WYVYAFLsSLPWVGK
0 1 S201‑p RIFANTEsYLkRRQK
0 1 K204‑ac ANTEsYLkRRQKTHV
0 1 K204‑m1 ANTEsYLkRRQKTHV
0 1 K204‑ub ANTEsYLkRRQKTHV
0 1 S306‑p EGPVMPGsHSVERFV
0 1 S386‑p LCKLQPGsLPQVLAQ
0 1 T395‑p PQVLAQAtEMLYMRL
0 1 K455‑ub FVREVLEkCMRLSYH
0 1 T513‑p VAFKSKAtNDEIFSI
0 1 K522 DEIFSILKDVPNPNQ
0 1 K574‑ac AKFHEVFkTLAESDE
0 1 K583‑ub LAESDEGkLHVLRVM
0 1 T611‑p LVDKMIRtQIVDCAA
0 1 T633‑p SELSRDFtRLFVWEI
0 1 S643‑p FVWEILHstIRKMNK
0 1 T644‑p VWEILHstIRKMNKH
0 1 R668 EAKEKLARQHKRRsD
0 1 R672 KLARQHKRRsDDDDR
0 1 R673 LARQHKRRsDDDDRS
0 6 S674‑p ARQHKRRsDDDDRSS
0 1 K684‑ac DDRSSDRkDGVLEEQ
0 4 K698‑ac QIERLQEkVESAQSE
0 1 K707‑ac ESAQSEQkNLFLVIF
0 1 S734‑p RCETDGTsVLtPWYK
0 1 T737‑p TDGTsVLtPWYKNCI
  mouse

 
S7‑p _MSRRRHsyENDGGQ
Y8‑p MSRRRHsyENDGGQP
K17‑ub NDGGQPHkRRKtsDA
T21‑p QPHkRRKtsDANEtE
S22‑p PHkRRKtsDANEtED
T27‑p KtsDANEtEDHLEsL
S33‑p EtEDHLEsLICKVGE
K41 LICKVGEKSACSLES
K117 RQLKESLKANNYNEA
Y126 NNYNEAVYLVRFLSD
S175 WYVYAFLSSLPWVGK
S201 RIFSTTESYLKRRQK
K204 STTESYLKRRQKTHV
K204 STTESYLKRRQKTHV
K204 STTESYLKRRQKTHV
S306 EGPVMPGSHSVERFV
S386 LCKLQPGSLPQVLAQ
T395 PQVLAQATEMLYMRL
K455 FVREVLEKCMRLSYH
T513 VAFKSKATNDEIFSI
K522‑ub DEIFSILkDVPNPNQ
K574 AKFHEVFKTLAESDK
K583 LAESDKGKLHVLRVM
T611 LVDKMIRTQIVDCAA
T633 SELSRDFTRLFVWEI
S643 FVWEILHSTIRKMNK
T644 VWEILHSTIRKMNKH
R668‑m1 EAKEKLArQHKrrsD
R672‑m1 KLArQHKrrsDDDDR
R673‑m1 LArQHKrrsDDDDRS
S674‑p ArQHKrrsDDDDRSS
K684 DDRSSDRKDGALEEQ
K698 QIERLQEKVEAAQSE
K707 EAAQSEQKNLFLVIF
S734 RCETDGTSILTPWYK
T737 TDGTSILTPWYKNCI
  rat

 
S7‑p _MSRRRHsYENDGGQ
Y8 MSRRRHsYENDGGQP
K17 NDGGQPHKRRKtsDA
T21‑p QPHKRRKtsDANETE
S22‑p PHKRRKtsDANETED
T27 KtsDANETEDHLESL
S33 ETEDHLESLICKVGE
K41 LICKVGEKSACSLES
K117 RQLKESLKANNYNEA
Y126 NNYNEAVYLVRFLSD
S175 WYVYAFLSSLPWVGK
S201 RIFSSTESYLKRRQK
K204 SSTESYLKRRQKTHV
K204 SSTESYLKRRQKTHV
K204 SSTESYLKRRQKTHV
S306 EGPVMPGSHSVERFV
S386 LCKLQPGSLPQVLAQ
T395 PQVLAQATEMLYMRL
K455 FVREVLEKCMRLSYH
T513 VAFKSKATNDEIFSI
K522 DEIFSILKDVPNPNQ
K574 AKFHEVFKTLAESDK
K583 LAESDKGKLHVLRVM
T611 LVDKMIRTQIVDCAA
T633 SELSRDFTRLFVWEI
S643 FVWEILHSTIRKMNK
T644 VWEILHSTIRKMNKH
R668 EAKEKLARQHKRRSD
R672 KLARQHKRRSDDDDR
R673 LARQHKRRSDDDDRG
S674 ARQHKRRSDDDDRGS
K684 DDRGSDRKDGALEEQ
K698 QIERLQEKVESAQSE
K707 ESAQSEQKNLFLVIF
S734 RCETDGTSILTPWYK
T737 TDGTSILTPWYKNCI
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