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Protein Page:
SLC1A1 (human)

SLC1A1 Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium. Negatively regulated by ARL6IP5. Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family. SLC1A1 subfamily. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family
Chromosomal Location of Human Ortholog: 9p24
Cellular Component: apical plasma membrane; integral to plasma membrane; membrane; plasma membrane
Molecular Function: amino acid transmembrane transporter activity; cysteine transmembrane transporter activity; high-affinity glutamate transmembrane transporter activity; L-glutamate transmembrane transporter activity
Biological Process: cysteine transport; glutamate secretion; ion transport; L-glutamate import; synaptic transmission
Disease: Schizophrenia 18
Reference #:  P43005 (UniProtKB)
Alt. Names/Synonyms: EAA3; EAAC1; EAAT3; excitatory amino acid carrier 1; Excitatory amino acid transporter 3; excitatory amino acid transporter-3; Excitatory amino-acid carrier 1; Neuronal and epithelial glutamate transporter; SLC1A1; Sodium-dependent glutamate/aspartate transporter 3; solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1; Solute carrier family 1 member 1
Gene Symbols: SLC1A1
Molecular weight: 57,100 Da
Basal Isoelectric point: 5.56  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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