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Protein Page:
CA9 (human)

Overview
CA9 Reversible hydration of carbon dioxide. Participates in pH regulation. May be involved in the control of cell proliferation and transformation. Appears to be a novel specific biomarker for a cervical neoplasia. Forms oligomers linked by disulfide bonds. By hypoxia. Expressed primarily in carcinoma cells lines. Expression is restricted to very few normal tissues and the most abundant expression is found in the epithelial cells of gastric mucosa. Inhibited by coumarins, saccharin, sulfonamide derivatives such as acetazolamide (AZA) and Foscarnet (phosphonoformate trisodium salt). Belongs to the alpha-carbonic anhydrase family. Note: This description may include information from UniProtKB.
Protein type: EC 4.2.1.1; Energy Metabolism - nitrogen; Lyase; Membrane protein, integral; Nucleolus
Chromosomal Location of Human Ortholog: 9p13.3
Cellular Component: plasma membrane
Molecular Function: carbonate dehydratase activity
Biological Process: bicarbonate transport
Reference #:  Q16790 (UniProtKB)
Alt. Names/Synonyms: CA-IX; CA9; CAH9; CAIX; Car9; Carbonate dehydratase IX; Carbonic anhydrase 9; Carbonic anhydrase IX; G250; Membrane antigen MN; MN; P54/58N; pMW1; RCC-associated antigen G250; RCC-associated protein G250; Renal cell carcinoma-associated antigen G250
Gene Symbols: CA9
Molecular weight: 49,698 Da
Basal Isoelectric point: 4.64  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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CA9

Protein Structure Not Found.
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