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Protein Page:
CSFR (mouse)

CSFR an oncogenic tyrosine kinase receptor for CSF-1 (M-CSF). Drives growth and development of monocytes. Binding of CSF-1 induces receptor dimerization, activation and autophosphorylation of cytoplasmic tyrosine residues used as docking sites for SH2-containing signaling proteins. There are at least five major tyrosine autophosphorylation sites. Two point mutations seen in 10-20% of patients with acute myeloid leukemia, chronic myelomonocytic leukemia or myelodysplasia. One mutation appears to be both somatic and germline, and disrupts Cbl binding and receptor turnover. v-fms lacks the Cbl binding site and causes feline leukemia. Mutations may also develop after chemotherapy for lymphoma. A distinct point mutation was found in some cases of hepatocellular carcinoma and related to increased expression, and another mutation was found in 2 of 40 patients with idiopathic myelofibrosis. Expression is elevated in breast tumors and cell lines, and expression in xenografts and transgenic mice has been correlated with xenograft growth and breast cancer development. Inhibitors: Ki-20227 and other Kit/PDGFR inhibitors. Note: This description may include information from UniProtKB.
Protein type: EC; Kinase, protein; Membrane protein, integral; Oncoprotein; PDGFR family; Protein kinase, TK; Protein kinase, tyrosine (receptor); TK group
Chromosomal Location of Human Ortholog: 18 E1|18 34.41 cM
Cellular Component: cell surface; membrane; plasma membrane
Molecular Function: cytokine binding; macrophage colony stimulating factor receptor activity; protein binding; protein homodimerization activity; protein phosphatase binding; transmembrane receptor protein tyrosine kinase activity
Biological Process: axon guidance; cell proliferation; cytokine and chemokine mediated signaling pathway; forebrain neuron differentiation; hemopoiesis; intercellular junction maintenance; negative regulation of apoptosis; negative regulation of cell proliferation; olfactory bulb development; osteoclast differentiation; peptidyl-tyrosine phosphorylation; phosphatidylinositol metabolic process; phosphoinositide-mediated signaling; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of osteoclast differentiation; positive regulation of protein amino acid phosphorylation; positive regulation of tyrosine phosphorylation of Stat3 protein; protein amino acid autophosphorylation; regulation of bone resorption; regulation of cell shape; ruffle organization and biogenesis; transmembrane receptor protein tyrosine kinase signaling pathway
Reference #:  P09581 (UniProtKB)
Alt. Names/Synonyms: AI323359; c-fms; CD115; colony stimulating factor 1 receptor; CSF-1-R; CSF-1R; Csf1r; Csfmr; Fim-2; Fms; M-CSFR; Macrophage colony-stimulating factor 1 receptor; OTTMUSP00000015851; Proto-oncogene c-Fms; proto-oncogene fms
Gene Symbols: Csf1r
Molecular weight: 109,179 Da
Basal Isoelectric point: 5.84  Predict pI for various phosphorylation states
CST Pathways:  Tyrosine Kinases & Substrates
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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