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Protein Page:
IRF4 (human)

IRF4 Transcriptional activator. Binds to the interferon- stimulated response element (ISRE) of the MHC class I promoter. Binds the immunoglobulin lambda light chain enhancer, together with PU.1. Probably plays a role in ISRE-targeted signal transduction mechanisms specific to lymphoid cells. Interacts with SPIB and DEF6. Not induced by interferons. Lymphoid cells. Belongs to the IRF family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Oncoprotein; Transcription factor
Chromosomal Location of Human Ortholog: 6p25-p23
Cellular Component: cytoplasm; cytosol; membrane; nucleoplasm; nucleus
Molecular Function: sequence-specific DNA binding; transcription factor activity
Biological Process: defense response to protozoan; positive regulation of interleukin-10 biosynthetic process; positive regulation of interleukin-13 biosynthetic process; positive regulation of interleukin-2 biosynthetic process; positive regulation of interleukin-4 biosynthetic process; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent
Disease: Skin/hair/eye Pigmentation, Variation In, 8
Reference #:  Q15306 (UniProtKB)
Alt. Names/Synonyms: Interferon regulatory factor 4; IRF-4; IRF4; LSIRF; Lymphocyte-specific interferon regulatory factor; Multiple myeloma oncogene 1; MUM1; NF-EM5
Gene Symbols: IRF4
Molecular weight: 51,772 Da
Basal Isoelectric point: 6.39  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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