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Protein Page:
ADAMTS1 (human)

Overview
ADAMTS1 Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. Has angiogenic inhibitor activity. Active metalloprotease, which may be associated with various inflammatory processes as well as development of cancer cachexia. May play a critical role in follicular rupture. Note: This description may include information from UniProtKB.
Protein type: EC 3.4.24.-; Motility/polarity/chemotaxis; Protease; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 21q21.2
Cellular Component: cytoplasm
Molecular Function: metallopeptidase activity
Biological Process: integrin-mediated signaling pathway; negative regulation of cell proliferation
Reference #:  Q9UHI8 (UniProtKB)
Alt. Names/Synonyms: A disintegrin and metalloproteinase with thrombospondin motifs 1; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 1; ADAM metallopeptidase with thrombospondin type 1 motif, 1; ADAM-TS 1; ADAM-TS1; ADAMTS-1; ADAMTS1; ATS1; C3-C5; human metalloproteinase with thrombospondin type 1 motifs; KIAA1346; METH-1; METH1
Gene Symbols: ADAMTS1
Molecular weight: 105,358 Da
Basal Isoelectric point: 6.4  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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ADAMTS1

Protein Structure Not Found.
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