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Protein Page:
BACH2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
BACH2 Transcriptional regulator that acts as repressor or activator. Binds to Maf recognition elements (MARE). Play important roles in coordinating transcription activation and repression by MAFK. Belongs to the bZIP family. CNC subfamily. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 6q15
Cellular Component: nucleus
Molecular Function: transcription factor activity; ubiquitin-protein ligase activity
Biological Process: transcription from RNA polymerase II promoter
Reference #:  Q9BYV9 (UniProtKB)
Alt. Names/Synonyms: BACH2; BTB and CNC homolog 2; BTB and CNC homology 1, basic leucine zipper transcription factor 2; Transcription regulator protein BACH2
Gene Symbols: BACH2
Molecular weight: 92,537 Da
Basal Isoelectric point: Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

BACH2

Protein Structure Not Found.
Download PyMol Script
Download ChimeraX Script


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Sites Implicated In
apoptosis, inhibited: S521‑p
cell growth, altered: S521‑p
transcription, altered: S521‑p
intracellular localization: S521‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 T40 KDILCDVTLIVERKE
0 1 T131 SCFSFLQTQLLNSED
0 1 A147 LFVCRKDAACQRPHE
0 3 S159‑p PHEDCENsAGEEEDE
0 1 T170 EEDEEEETMDSETAK
0 1 S173 EEEETMDSETAKMAC
2 0 K202‑sm AAIPVAEkEEALLPE
0 1 S220 PTDTKESSEKDALTQ
0 1 T250 YNASSHSTSGFASTF
0 1 S251 NASSHSTSGFASTFR
0 1 S255 HSTSGFASTFREDNS
0 1 T256 STSGFASTFREDNSS
0 1 R258 SGFASTFREDNSSNS
0 1 N261 ASTFREDNSSNSLKP
0 1 S265 REDNSSNSLKPGLAR
2 0 K276‑sm GLARGQIkSEPPSEE
0 1 S281 QIkSEPPSEENEEES
0 1 N284 SEPPSEENEEESITL
0 1 S288 SEENEEESITLCLsG
0 1 T290 ENEEESITLCLsGDE
0 2 S294‑p ESITLCLsGDEPDAK
0 1 P298 LCLsGDEPDAKDRAG
1 8 S315‑p EMDRKQPsPAPtPTA
0 3 T319‑p KQPsPAPtPTAPAGA
0 1 T321 PsPAPtPTAPAGAAC
1 2 A322 sPAPtPTAPAGAACL
0 2 A324 APtPTAPAGAACLER
0 1 S332 GAACLERSRsVAsPS
1 3 S334‑p ACLERSRsVAsPSCL
1 1 A336 LERSRsVAsPSCLRS
1 5 S337‑p ERSRsVAsPSCLRSL
1 1 S339 SRsVAsPSCLRSLFS
0 1 S343 AsPSCLRSLFSITKs
0 1 T348 LRSLFSITKsVELSG
0 1 S350‑p SLFSITKsVELSGLP
0 1 T377 CPFDKGITQGDLKTD
0 1 T383 ITQGDLKTDYTPFTG
0 1 T386 GDLKTDYTPFTGNYG
0 1 S403 HVGQKEVSNFTMGsP
0 7 S409‑p VSNFTMGsPLRGPGL
0 1 A418 LRGPGLEALCkQEGE
2 0 K421‑sm PGLEALCkQEGELDR
0 1 S430 EGELDRRSVIFSSSA
0 1 S434 DRRSVIFSSSACDQV
0 1 S436 RSVIFSSSACDQVST
1 1 T443 SACDQVSTSVHSYSG
0 1 S447 QVSTSVHSYSGVSSL
0 1 S449 STSVHSYSGVSSLDK
1 10 S510‑p PIKVCPRsPPLETRT
0 2 T515 PRsPPLETRTRTSsS
0 1 T519 PLETRTRTSsSCSsY
0 1 S520 LETRTRTSsSCSsYs
2 1 S521‑p ETRTRTSsSCSsYsY
0 1 S522 TRTRTSsSCSsYsYA
0 1 S524 TRTSsSCSsYsYAED
0 2 S525‑p RTSsSCSsYsYAEDG
0 2 S527‑p SsSCSsYsYAEDGSG
0 2 S533 YsYAEDGSGGSPCSL
1 2 S536 AEDGSGGSPCSLPLC
0 2 S539 GSGGSPCSLPLCEFs
0 2 S546‑p SLPLCEFsSSPCsQG
0 1 S547 LPLCEFsSSPCsQGA
0 1 S548 PLCEFsSSPCsQGAR
0 2 S551‑p EFsSSPCsQGARFLA
0 1 Y572‑p GLMGDGMyNQVRPQI
2 0 K580‑sm NQVRPQIkCEQSYGT
0 1 T587 kCEQSYGTNSSDESG
0 1 S589 EQSYGTNSSDESGSF
0 1 S590 QSYGTNSSDESGSFS
0 1 S593 GTNSSDESGSFSEAD
0 1 S595 NSSDESGSFSEADSE
0 1 S597 SDESGSFSEADSESC
1 1 S719 EVCRDIQSPEQIQAL
0 1 T799 SGRRLEGTDPGTFSE
0 1 T803 LEGTDPGTFSERGPP
0 1 S805 GTDPGTFSERGPPLE
0 1 S815 GPPLEPRSQTVTVDF
0 1 T817 PLEPRSQTVTVDFCQ
0 1 T819 EPRSQTVTVDFCQEM
  mouse

► Hide Isoforms
 
T40‑p KDILCDVtLIVERKE
T131‑p SCFSFLQtQLLNRED
S147‑p LFVCRKDsACQRPQE
S159‑p PQEDHGNsAGEEEEE
T169‑p EEEEEEEtMDsETAR
S172‑p EEEEtMDsETARMAC
K201‑sm TAIPVAEkEEALLPE
S219‑p PTDTKENsEKGALTQ
T249‑p YSAPSHGtsGFAstF
S250‑p SAPSHGtsGFAstFs
S254‑p HGtsGFAstFsEDsP
T255‑p GtsGFAstFsEDsPG
S257‑p sGFAstFsEDsPGNs
S260‑p AstFsEDsPGNsLKP
S264‑p sEDsPGNsLKPGLPM
K275‑sm GLPMGQIkSEPPsEE
S280‑p QIkSEPPsEEtEEEs
T283‑p SEPPsEEtEEEsItL
S287‑p sEEtEEEsItLCLsG
T289‑p EtEEEsItLCLsGDE
S293‑p EsItLCLsGDEtDIK
T297‑p LCLsGDEtDIKDRPG
S314‑p EMDRKQPsPAPtPst
T318‑p KQPsPAPtPstPtGA
S320‑p PsPAPtPstPtGAAC
T321‑p sPAPtPstPtGAACL
T323‑p APtPstPtGAACLDR
S331‑p GAACLDRsRsVssPs
S333‑p ACLDRsRsVssPsCL
S335‑p LDRsRsVssPsCLRs
S336‑p DRsRsVssPsCLRsL
S338‑p sRsVssPsCLRsLFG
S342‑p ssPsCLRsLFGItKG
T347‑p LRsLFGItKGVESTG
G349 sLFGItKGVESTGLP
S376‑p CPFNKGIsQGDLKtD
T382‑p IsQGDLKtDYtPLAG
T385‑p GDLKtDYtPLAGNYG
S402‑p HVGQKDVsNFAMGsP
S408‑p VsNFAMGsPLRGPGP
T417‑p LRGPGPEtLCkQEGE
K420‑sm PGPEtLCkQEGELDR
S429‑p EGELDRRsVIFsAsA
S433‑p DRRsVIFsAsACDQP
S435‑p RsVIFsAsACDQPNt
T442‑p sACDQPNtPVHsYsA
S446‑p QPNtPVHsYsAVSNL
S448‑p NtPVHsYsAVSNLDK
S509‑p PIKVCPRsPPLEtRT
T514‑p PRsPPLEtRTRtsss
T518‑p PLEtRTRtsssCssY
S519‑p LEtRTRtsssCssYs
S520‑p EtRTRtsssCssYsY
S521‑p tRTRtsssCssYsYA
S523‑p TRtsssCssYsYAED
S524‑p RtsssCssYsYAEDG
S526‑p sssCssYsYAEDGsG
S532‑p YsYAEDGsGGsPCsL
S535‑p AEDGsGGsPCsLPLC
S538‑p GsGGsPCsLPLCEFs
S545‑p sLPLCEFsssPCsQG
S546‑p LPLCEFsssPCsQGA
S547‑p PLCEFsssPCsQGAR
S550‑p EFsssPCsQGARFLA
Y571 GLMGDGMYNQVRPQI
K579‑sm NQVRPQIkCEQSYGt
T586‑p kCEQSYGtNssDEsG
S588‑p EQSYGtNssDEsGsF
S589‑p QSYGtNssDEsGsFs
S592‑p GtNssDEsGsFsEAD
S594‑p NssDEsGsFsEADSE
S596‑p sDEsGsFsEADSESC
S718‑p EVCRDIQsPEQIQAL
S797‑p SGRRLEGsDPGtFsE
T801‑p LEGsDPGtFsERGPP
S803‑p GsDPGtFsERGPPLE
S813‑p GPPLEARsQsVtVDF
S815‑p PLEARsQsVtVDFCQ
T817‑p EARsQsVtVDFCQEM
  BACH2 iso2  
T40 KDILCDVTLIVERKE
T131 SCFSFLQTQLLNRED
S147 LFVCRKDSACQRPQE
S159 PQEDHGNSAGEEEEE
T169 EEEEEEETMDSETAR
S172 EEEETMDSETARMAC
K201 TAIPVAEKEEALLPE
S219 PTDTKENSEKGALTQ
T249 YSAPSHGTSGFASTF
S250 SAPSHGTSGFASTFS
S254 HGTSGFASTFSEDSP
T255 GTSGFASTFSEDSPG
S257 SGFASTFSEDSPGNS
S260 ASTFSEDSPGNSLKP
S264 SEDSPGNSLKPGLPM
K275 GLPMGQIKSEPPSEE
S280 QIKSEPPSEETEEES
T283 SEPPSEETEEESITL
S287 SEETEEESITLCLSG
T289 ETEEESITLCLSGDE
S293 ESITLCLSGDETDIK
T297 LCLSGDETDIKDRPG
S314‑p EMDRKQPsPAPTPST
T318 KQPsPAPTPSTPTGA
S320 PsPAPTPSTPTGAAC
T321 sPAPTPSTPTGAACL
T323 APTPSTPTGAACLDR
S331 GAACLDRSRSVSSPS
S333 ACLDRSRSVSSPSCL
S335 LDRSRSVSSPSCLRS
S336 DRSRSVSSPSCLRSL
S338 SRSVSSPSCLRSLFG
S342 SSPSCLRSLFGITKG
T347 LRSLFGITKGVESTG
G349 SLFGITKGVESTGLP
S376 CPFNKGISQGDLKTD
T382 ISQGDLKTDYTPLAG
T385 GDLKTDYTPLAGNYG
S402 HVGQKDVSNFAMGSP
S408 VSNFAMGSPLRGPGP
T417 LRGPGPETLCKFSSS
K420 PGPETLCKFSSSPCS
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
S422 PETLCKFSSSPCSQG
S423 ETLCKFSSSPCSQGA
S424 TLCKFSSSPCSQGAR
S427 KFSSSPCSQGARFLA
Y448 GLMGDGMYNQVRPQI
K456 NQVRPQIKCEQSYGT
T463 KCEQSYGTNSSDESG
S465 EQSYGTNSSDESGSF
S466 QSYGTNSSDESGSFS
S469 GTNSSDESGSFSEAD
S471 NSSDESGSFSEADSE
S473 SDESGSFSEADSESC
S595 EVCRDIQSPEQIQAL
S674 SGRRLEGSDPGTFSE
T678 LEGSDPGTFSERGPP
S680 GSDPGTFSERGPPLE
S690 GPPLEARSQSVTVDF
S692 PLEARSQSVTVDFCQ
T694 EARSQSVTVDFCQEM
  rat

 
T40 KDILCDVTLIVERKE
T131 SCFSFLQTQLLNRED
S147 LFVCRKDSACQRPQE
S159 PQEDHGNSAGEEEEE
T169 EEEEEEETMDSETAR
S172 EEEETMDSETARMAC
K201 TAIPVAEKEEALLPE
S219 PTDTKENSEKGALTQ
T249 YSAASHGTSGFAGTF
S250 SAASHGTSGFAGTFS
G254 HGTSGFAGTFSEESP
T255 GTSGFAGTFSEESPG
S257 SGFAGTFSEESPGNS
S260 AGTFSEESPGNSLKP
S264 SEESPGNSLKPGLSV
K275 GLSVGQIKSEPPNEE
N280 QIKSEPPNEETEEES
T283 SEPPNEETEEESITL
S287 NEETEEESITLCLSG
T289 ETEEESITLCLSGDE
S293 ESITLCLSGDETDIK
T297 LCLSGDETDIKDRPG
S314 EMDRKQPSPAPPPGT
P318 KQPSPAPPPGTPTGA
G320 PSPAPPPGTPTGATS
T321 SPAPPPGTPTGATSL
T323 APPPGTPTGATSLDR
S331 GATSLDRSRSVSSPS
S333 TSLDRSRSVSSPSCL
S335 LDRSRSVSSPSCLRS
S336 DRSRSVSSPSCLRSL
S338 SRSVSSPSCLRSLFS
S342 SSPSCLRSLFSIAKG
A347 LRSLFSIAKGVESTG
G349 SLFSIAKGVESTGLP
S376 CPFNKGISQGDLKTD
T382 ISQGDLKTDYTPLAG
T385 GDLKTDYTPLAGNYG
S402 HVGQKDVSNFAMGsP
S408‑p VSNFAMGsPLRGPGP
T417 LRGPGPETLCKQEGE
K420 PGPETLCKQEGELDR
S429 EGELDRRSVIFSAST
S433 DRRSVIFSASTCDQP
S435 RSVIFSASTCDQPNT
T442 STCDQPNTPVHSYSS
S446 QPNTPVHSYSSVSSL
S448 NTPVHSYSSVSSLDK
S509 PIKVCPRSPPLETRT
T514 PRSPPLETRTRTSSS
T518 PLETRTRTSSSCSSY
S519 LETRTRTSSSCSSYS
S520 ETRTRTSSSCSSYSY
S521 TRTRTSSSCSSYSYA
S523 TRTSSSCSSYSYAED
S524 RTSSSCSSYSYAEDG
S526 SSSCSSYSYAEDGSG
S532 YSYAEDGSGGSPCSL
S535 AEDGSGGSPCSLPLC
S538 GSGGSPCSLPLCEFS
S545 SLPLCEFSSSPCSQG
S546 LPLCEFSSSPCSQGA
S547 PLCEFSSSPCSQGAR
S550 EFSSSPCSQGARFLA
Y571 GLMGDGMYNQVRPQI
K579 NQVRPQIKCEQSYGT
T586 KCEQSYGTNSSDESG
S588 EQSYGTNSSDESGSF
S589 QSYGTNSSDESGSFS
S592 GTNSSDESGSFSEAD
S594 NSSDESGSFSEADSE
S596 SDESGSFSEADSESC
S718 EVCRDIQSPEQIQAL
S797 SGRRLEGSDPGTFSE
T801 LEGSDPGTFSERGPP
S803 GSDPGTFSERGPPLE
S813 GPPLEARSQSVTVDF
S815 PLEARSQSVTVDFCQ
T817 EARSQSVTVDFCQEM
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