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Protein Page:
PPP1CC (human)

Overview
PPP1CC is a catalytic subunit of protein phosphatase 1 (PP1), a ubiquitous cytosolic serine-threonine phosphatase. Composed a catalytic subunit (PPP1CA, PPP1CB or PPP1CC) which is folded into its native form by inhibitor 2 and glycogen synthetase kinase 3, and then complexed to one or several targeting (or regulatory) subunits: PPP1R12A and PPP1R12B mediate binding to myosin; PPP1R3A, PPP1R3B, PPP1R3C and PPP1R3D mediate binding to glycogen; and PPP1R15A and PPP1R15B mediate binding to EIF2S1. PP1 is essential for cell division, plays critical roles in many cellular processes including glycogen metabolism, muscle contractility and protein synthesis, and is involved in the regulation of ionic conductances and long-term synaptic plasticity. Inhibits the synthesis of proteins involved in synaptic plasticity. Binds to the transcription factor cyclic AMP-dependent response element binding (CREB) and dephosphorylates it. May regulate chromatin condensation through regulation of histone H3 phosphorylation. Differentially expressed in gastric cancer. May participate in the neurodegenerative progress in Alzheimer's disease. Down-regulated in lung squamous cell carcinoma. Note: This description may include information from UniProtKB.
Protein type: EC 3.1.3.16; Motility/polarity/chemotaxis; Nucleolus; Protein phosphatase, Ser/Thr (non-receptor)
Chromosomal Location of Human Ortholog: 12q24.1-q24.2
Cellular Component: cytoplasm; cytosol; focal adhesion; mitochondrion; nuclear chromosome, telomeric region; nucleolus; nucleus; protein complex
Molecular Function: phosphoprotein phosphatase activity; phosphoric monoester hydrolase activity; protein binding; protein kinase binding; protein N-terminus binding; protein serine/threonine phosphatase activity
Biological Process: circadian regulation of gene expression; entrainment of circadian clock by photoperiod; protein amino acid dephosphorylation; regulation of circadian rhythm; sister chromatid cohesion
Reference #:  P36873 (UniProtKB)
Alt. Names/Synonyms: PP-1G; PP1G; PP1gamma; PPP1CC; PPP1G; protein phosphatase 1, catalytic subunit, gamma isoform; protein phosphatase 1, catalytic subunit, gamma isozyme; Protein phosphatase 1C catalytic subunit; serine/threonine phosphatase 1 gamma; Serine/threonine-protein phosphatase PP1-gamma catalytic subunit
Gene Symbols: PPP1CC
Molecular weight: 36,984 Da
Basal Isoelectric point: 6.12  Predict pI for various phosphorylation states
CST Pathways:  Growth And Differentiation Control by MAPKs  |  Insulin Receptor Signaling  |  Parkinson's Disease  |  Translation: eIF2
Select Structure to View Below

PPP1CC

Protein Structure Not Found.
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