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Protein Page:
IGF1R (rat)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
IGF1R a receptor tyrosine kinase that binds insulin-like growth factor 1 (IGF1) with a high affinity and IGF2 with a lower affinity. Functions as an anti-apoptotic agent by enhancing cell survival. Can play a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. Tetramer of 2 alpha and 2 beta chains linked by disulfide bonds. The alpha chains contribute to the formation of the ligand- binding domain, while the beta chain carries the kinase domain. Interacts with PIK3R1 and with the PTB/PID domains of IRS1 and SHC1 in vitro when autophosphorylated on tyrosine residues. Mutated in rare cases of pre- and post-natal growth retardation. One SNP associated with increased human longevity. Increased expression of IGF1R and other pathway members associated with progression and malignancy in a range of cancers. Inhibitors: AG1024, AEW541. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, TK; Kinase, protein; Membrane protein, integral; EC 2.7.10.1; Protein kinase, tyrosine (receptor); TK group; InsR family
Cellular Component: axon; caveola; cell soma; cytoplasm; integral to membrane; intracellular membrane-bound organelle; membrane; neuron projection; nucleus; plasma membrane; receptor complex; T-tubule
Molecular Function: G-protein alpha-subunit binding; identical protein binding; insulin binding; insulin receptor binding; insulin receptor substrate binding; insulin-like growth factor binding; insulin-like growth factor I binding; insulin-like growth factor receptor activity; phosphoinositide 3-kinase binding; protein binding; protein-tyrosine kinase activity
Biological Process: adrenal gland development; aging; axonogenesis; brain development; cellular response to insulin stimulus; cerebellum development; epidermis development; establishment of cell polarity; exocrine pancreas development; hippocampus development; immune response; inactivation of MAPKK activity; insulin-like growth factor receptor signaling pathway; male sex determination; mammary gland development; negative regulation of apoptosis; negative regulation of MAPKKK cascade; negative regulation of protein kinase B signaling cascade; negative regulation of transcription factor activity; neurite development; organ morphogenesis; phosphoinositide-mediated signaling; positive regulation of axon regeneration; positive regulation of cell migration; positive regulation of cytokinesis; positive regulation of DNA metabolic process; positive regulation of DNA replication; positive regulation of MAPKKK cascade; positive regulation of meiotic cell cycle; positive regulation of mitosis; positive regulation of osteoblast proliferation; positive regulation of phosphoinositide 3-kinase cascade; positive regulation of protein kinase B signaling cascade; positive regulation of smooth muscle cell proliferation; positive regulation of transcription, DNA-dependent; protein amino acid autophosphorylation; protein amino acid phosphorylation; protein heterooligomerization; protein tetramerization; regulation of JNK cascade; response to insulin stimulus; response to vitamin E
Reference #:  P24062 (UniProtKB)
Alt. Names/Synonyms: IGF-I receptor; Igf1r; IGFIRC; Insulin-like growth factor 1 receptor; Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain; Insulin-like growth factor I receptor; JTK13
Gene Symbols: Igf1r
Molecular weight: 155,396 Da
Basal Isoelectric point: 5.57  Predict pI for various phosphorylation states
CST Pathways:  Angiogenesis  |  ESC Pluripotency and Differentiation  |  Tyrosine Kinases & Substrates
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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IGF1R

Protein Structure Not Found.
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Substrate Sequence Logo
Sequence Logo

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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       rat

 
0 1 Y113 IRGWKLFYNYALVIF
0 1 Y115 GWKLFYNYALVIFEM
0 1 T123 ALVIFEMTNLKDIGL
0 1 Y131 NLKDIGLYNLRNITR
0 1 R472 EVTGTKGRQSKGDIN
0 1 R481 SKGDINTRNNGERAS
0 1 S624 DVLSASNSSSQLIVK
0 1 S625 VLSASNSSSQLIVKW
2 0 Y974 RLGNGVLYASVNPEY
6 4 Y981 YASVNPEYFSAADVY
1 0 S983 SVNPEYFSAADVYVP
0 3 Y1015 QGSFGMVYEGVAKGV
0 1 K1024 GVAKGVVKDEPETRV
0 6 K1034 PETRVAIKTVNEAAS
2 0 K1056 LNEASVMKEFNCHHV
2 0 K1131 MAYLNANKFVHRDLA
1 0 K1151 VAEDFTVKIGDFGMT
16 466 Y1162‑p FGMTRDIyETDyyRK
0 49 T1164 MTRDIyETDyyRKGG
13 721 Y1166‑p RDIyETDyyRKGGKG
11 117 Y1167‑p DIyETDyyRKGGKGL
0 2 K1172 DyyRKGGKGLLPVRW
0 1 S1194 DGVFTTHSDVWSFGV
1 1 S1279 EPSFQEVSFYYSEEN
5 0 Y1281 SFQEVSFYYSEENKP
5 0 Y1282 FQEVSFYYSEENKPP
2 0 S1315 VPLDPSASSASLPLP
2 0 S1316 PLDPSASSASLPLPE
2 0 A1317 LDPSASSASLPLPER
2 0 S1318 DPSASSASLPLPERH
1 0 S1326 LPLPERHSGHKAENG
0 7 S1342 GVLVLRASFDERQPY
3 28 Y1349 SFDERQPYAHMNGGR
0 1 A1357 AHMNGGRANERALPL
0 11 T1369 LPLPQSSTC______
4568 : Phospho-IGF-I Receptor beta (Tyr980) (C14A11) Rabbit mAb
3021 : Phospho-IGF-I Receptor beta (Tyr1131)/Insulin Receptor beta (Tyr1146) Antibody
2969 : Phospho-IGF-I Receptor beta (Tyr1135/1136)/Insulin Receptor beta (Tyr1150/1151) (19H7) Rabbit mAb (Biotinylated)
3024 : Phospho-IGF-I Receptor beta (Tyr1135/1136)/Insulin Receptor beta (Tyr1150/1151) (19H7) Rabbit mAb
3918 : Phospho-IGF-1 Receptor beta (Tyr1135) (DA7A8) Rabbit mAb
2969 : Phospho-IGF-I Receptor beta (Tyr1135/1136)/Insulin Receptor beta (Tyr1150/1151) (19H7) Rabbit mAb (Biotinylated)
3024 : Phospho-IGF-I Receptor beta (Tyr1135/1136)/Insulin Receptor beta (Tyr1150/1151) (19H7) Rabbit mAb
6113 : Phospho-IGF-I Receptor beta (Tyr1316) Antibody
  human

 
Y113‑p IRGWKLFyNyALVIF
Y115‑p GWKLFyNyALVIFEM
T123‑p ALVIFEMtNLKDIGL
Y131‑p NLKDIGLyNLRNITR
R471‑m1 EVTGTKGrQSKGDIN
R480‑m1 SKGDINTrNNGERAS
S623‑p DVLSASNssSQLIVK
S624‑p VLSASNssSQLIVKW
Y973 RLGNGVLYASVNPEy
Y980‑p YASVNPEyFsAADVY
S982‑p SVNPEyFsAADVYVP
Y1014‑p QGSFGMVyEGVAKGV
K1023 GVAKGVVKDEPETRV
K1033‑ub PETRVAIkTVNEAAS
K1055‑sm LNEASVMkEFNCHHV
K1130‑sm MAYLNANkFVHRDLA
K1150‑sm VAEDFTVkIGDFGMT
Y1161‑p FGMTRDIyEtDyyRK
T1163‑p MTRDIyEtDyyRKGG
Y1165‑p RDIyEtDyyRKGGkG
Y1166‑p DIyEtDyyRKGGkGL
K1171‑ub DyyRKGGkGLLPVRW
S1193‑p DGVFTTYsDVWSFGV
S1278‑p EPGFREVsFyySEEN
Y1280‑p GFREVsFyySEENKL
Y1281‑p FREVsFyySEENKLP
S1310‑p VPLDPSAssssLPLP
S1311‑p PLDPSAssssLPLPD
S1312‑p LDPSAssssLPLPDR
S1313‑p DPSAssssLPLPDRH
S1321‑p LPLPDRHsGHKAENG
S1339‑p GVLVLRAsFDERQPy
Y1346‑p sFDERQPyAHMNGGR
K1354‑m1 AHMNGGRkNERALPL
T1366‑p LPLPQSStC______
4568 : Phospho-IGF-I Receptor beta (Tyr980) (C14A11) Rabbit mAb
3021 : Phospho-IGF-I Receptor beta (Tyr1131)/Insulin Receptor beta (Tyr1146) Antibody
2969 : Phospho-IGF-I Receptor beta (Tyr1135/1136)/Insulin Receptor beta (Tyr1150/1151) (19H7) Rabbit mAb (Biotinylated)
3024 : Phospho-IGF-I Receptor beta (Tyr1135/1136)/Insulin Receptor beta (Tyr1150/1151) (19H7) Rabbit mAb
3918 : Phospho-IGF-1 Receptor beta (Tyr1135) (DA7A8) Rabbit mAb
2969 : Phospho-IGF-I Receptor beta (Tyr1135/1136)/Insulin Receptor beta (Tyr1150/1151) (19H7) Rabbit mAb (Biotinylated)
3024 : Phospho-IGF-I Receptor beta (Tyr1135/1136)/Insulin Receptor beta (Tyr1150/1151) (19H7) Rabbit mAb
3918 : Phospho-IGF-1 Receptor beta (Tyr1135) (DA7A8) Rabbit mAb
6113 : Phospho-IGF-I Receptor beta (Tyr1316) Antibody
  mouse

 
Y113 IRGWKLFYNYALVIF
Y115 GWKLFYNYALVIFEM
T123 ALVIFEMTNLKDIGL
Y131 NLKDIGLYNLRNITR
R472 EVTGTKGRQSKGDIN
R481 SKGDINTRNNGERAS
S624 DVLSASNSSSQLIVK
S625 VLSASNSSSQLIVKW
Y974‑p RLGNGVLyASVNPEy
Y981‑p yASVNPEyFSAADVY
S983 SVNPEyFSAADVYVP
Y1015 QGSFGMVYEGVAKGV
K1024‑ac GVAKGVVkDEPETRV
K1034‑ub PETRVAIkTVNEAAS
K1056 LNEASVMKEFNCHHV
K1132 MAYLNANKFVHRDLA
K1152 VAEDFTVKIGDFGMT
Y1163‑p FGMTRDIyEtDyyRK
T1165‑p MTRDIyEtDyyRKGG
Y1167‑p RDIyEtDyyRKGGkG
Y1168‑p DIyEtDyyRKGGkGL
K1173‑ub DyyRKGGkGLLPVRW
S1195 DGVFTTHSDVWSFGV
S1280 EPSFQEVSFyySEEN
Y1282‑p SFQEVSFyySEENKP
Y1283‑p FQEVSFyySEENKPP
S1316 VPLDPSASSASLPLP
S1317 PLDPSASSASLPLPE
A1318 LDPSASSASLPLPER
S1319 DPSASSASLPLPERH
S1327 LPLPERHSGHKAENG
S1345‑p GVLVLRAsFDERQPy
Y1352‑p sFDERQPyAHMNGGR
A1360 AHMNGGRANERALPL
T1372‑p LPLPQSStC______
4568 : Phospho-IGF-I Receptor beta (Tyr980) (C14A11) Rabbit mAb
3021 : Phospho-IGF-I Receptor beta (Tyr1131)/Insulin Receptor beta (Tyr1146) Antibody
2969 : Phospho-IGF-I Receptor beta (Tyr1135/1136)/Insulin Receptor beta (Tyr1150/1151) (19H7) Rabbit mAb (Biotinylated)
3024 : Phospho-IGF-I Receptor beta (Tyr1135/1136)/Insulin Receptor beta (Tyr1150/1151) (19H7) Rabbit mAb
3918 : Phospho-IGF-1 Receptor beta (Tyr1135) (DA7A8) Rabbit mAb
2969 : Phospho-IGF-I Receptor beta (Tyr1135/1136)/Insulin Receptor beta (Tyr1150/1151) (19H7) Rabbit mAb (Biotinylated)
3024 : Phospho-IGF-I Receptor beta (Tyr1135/1136)/Insulin Receptor beta (Tyr1150/1151) (19H7) Rabbit mAb
6113 : Phospho-IGF-I Receptor beta (Tyr1316) Antibody
  pig

 
Y113 IRGWKLFYNYALVIF
Y115 GWKLFYNYALVIFEM
T123 ALVIFEMTNLKDIGL
Y131 NLKDIGLYNLRNITR
R471 EVTGTKGRQSKGDIN
R480 SKGDINTRNNGERAS
S623 DVLSASNSSSQLIVK
S624 VLSASNSSSQLIVKW
Y973 RLGNGVLYASVNPEY
Y980 YASVNPEYFSAADVY
S982 SVNPEYFSAADVYVP
Y1014 QGSFGMVYEGVAKGV
K1023 GVAKGVVKDEPETRV
K1033 PETRVAIKTVNEAAS
K1055 LNEASVMKEFNCHHV
K1130 MAYLNANKFVHRDLA
K1150 VAEDFTVKIGDFGMT
Y1161‑p FGMTRDIyETDYYRK
T1163 MTRDIyETDYYRKGG
Y1165 RDIyETDYYRKGGKG
Y1166 DIyETDYYRKGGKGL
K1171 DYYRKGGKGLLPVRW
S1193 DGVFTTHSDVWSFGV
S1278 EPGFREVSFYYSEEN
Y1280 GFREVSFYYSEENKP
Y1281 FREVSFYYSEENKPP
S1310 VPLDPSASSSSLPLP
S1311 PLDPSASSSSLPLPD
S1312 LDPSASSSSLPLPDR
S1313 DPSASSSSLPLPDRH
S1321 LPLPDRHSGHKAENG
S1339 GVLVLRASFDERQPY
Y1346 SFDERQPYAHMNGGR
K1354 AHMNGGRKNERALPL
T1366 LPLPQSSTC______
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