a receptor tyrosine kinase that binds insulin-like growth factor 1 (IGF1) with a high affinity and IGF2 with a lower affinity. Functions as an anti-apoptotic agent by enhancing cell survival. Can play a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. Tetramer of 2 alpha and 2 beta chains linked by disulfide bonds. The alpha chains contribute to the formation of the ligand- binding domain, while the beta chain carries the kinase domain. Interacts with PIK3R1 and with the PTB/PID domains of IRS1 and SHC1 in vitro when autophosphorylated on tyrosine residues. Mutated in rare cases of pre- and post-natal growth retardation. One SNP associated with increased human longevity. Increased expression of IGF1R and other pathway members associated with progression and malignancy in a range of cancers. Inhibitors: AG1024, AEW541. Note: This description may include information from UniProtKB.
Protein type: EC 220.127.116.11; InsR family; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor); TK group
Biological Process: adrenal gland development; axonogenesis; brain development; cellular response to insulin stimulus; epidermis development; establishment of cell polarity; exocrine pancreas development; immune response; inactivation of MAPKK activity; insulin-like growth factor receptor signaling pathway; male sex determination; mammary gland development; negative regulation of apoptosis; negative regulation of MAPKKK cascade; negative regulation of protein kinase B signaling cascade; negative regulation of transcription factor activity; neurite development; organ morphogenesis; phosphoinositide-mediated signaling; positive regulation of axon regeneration; positive regulation of cell migration; positive regulation of cytokinesis; positive regulation of DNA metabolic process; positive regulation of DNA replication; positive regulation of MAPKKK cascade; positive regulation of meiotic cell cycle; positive regulation of mitosis; positive regulation of osteoblast proliferation; positive regulation of phosphoinositide 3-kinase cascade; positive regulation of protein kinase B signaling cascade; positive regulation of smooth muscle cell proliferation; positive regulation of transcription, DNA-dependent; protein amino acid autophosphorylation; protein amino acid phosphorylation; protein heterooligomerization; protein tetramerization; regulation of JNK cascade