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Protein Page:
ADRB1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
ADRB1 a GPCR-coupled 7 transmembrane receptor that binds epinephrine and norepinephrine with approximately equal affinity. Mediates the catecholamine-induced activation of adenylate cyclase through the action of G proteins. Interacts with PIST and PSD-95. Localized at the plasma membrane and in the Golgi upon PIST overexpression. Homologous desensitization of the receptor is mediated by its phosphorylation by beta-adrenergic receptor kinase. Note: This description may include information from UniProtKB.
Protein type: Receptor, GPCR; GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 10q25.3
Cellular Component: early endosome; integral to plasma membrane; plasma membrane
Molecular Function: alpha-2A adrenergic receptor binding; beta-adrenergic receptor activity; epinephrine binding; norepinephrine binding; PDZ domain binding; protein binding; protein heterodimerization activity; Ras guanyl-nucleotide exchange factor activity; receptor signaling protein activity
Biological Process: adenylate cyclase activation; cell-cell signaling; norepinephrine-epinephrine vasodilation involved in regulation of systemic arterial blood pressure; positive regulation of cAMP biosynthetic process; positive regulation of GTPase activity; positive regulation of heart rate by epinephrine-norepinephrine; thermoregulation
Disease: Resting Heart Rate, Variation In
Reference #:  P08588 (UniProtKB)
Alt. Names/Synonyms: ADRB1; ADRB1R; adrenergic, beta-1-, receptor; B1AR; Beta-1 adrenergic receptor; Beta-1 adrenoceptor; Beta-1 adrenoreceptor; BETA1AR; RHR
Gene Symbols: ADRB1
Molecular weight: 51,323 Da
Basal Isoelectric point: 9.23  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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ADRB1

Protein Structure Not Found.
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Sites Implicated In
molecular association, regulation: S312‑p
receptor desensitization, altered: S312‑p
receptor recycling, altered: S312‑p
receptor recycling, induced: S312‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 Y157‑p CVIALDRyLAITSPF
0 1 T181 RARGLVCTVWAISAL
0 1 S186 VCTVWAISALVSFLP
0 1 S274 GGPARPPSPSPSPVP
5 0 S312‑p RAGKRRPsRLVALRE
0 2 R357‑m2 HRELVPDrLFVFFNW
0 2 S423‑p ARPGPPPsPGAAsDD
0 5 S428‑p PPsPGAAsDDDDDDV
1 0 S475‑p RPGFASEsKV_____
  mouse

 
Y157 CVIALDRYLAITSPF
T181‑p RARALVCtVWAIsAL
S186‑p VCtVWAIsALVSFLP
S274‑p GGPARPPsPEPSPSP
S301 RSSKRRPSRLVALRE
R346 HRDLVPDRLFVFFNW
S412‑p ARAGPPPsPGAPsDD
S417‑p PPsPGAPsDDDDDDA
S464 RQGFSSESKV_____
  rat

 
Y157 CVIALDRYLAITLPF
T181 RARALVCTVWAISAL
S186 VCTVWAISALVSFLP
S274 TGPPRPPSPAPSPSP
S301 RSSKRRPSRLVALRE
R346 HRDLVPDRLFVFFNW
S412 ARAGPPPSPGAPsDD
S417‑p PPSPGAPsDDDDDDA
S464 RQGFSSESKV_____
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