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Protein Page:
PPP2CA (human)

Overview
PPP2CA ubiquitous cytosolic Ser/Thr protein phosphatase, catalytic subunit. The holoenzyme consists of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B'/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules. Note: This description may include information from UniProtKB.
Protein type: EC 3.1.3.16; Motility/polarity/chemotaxis; Protein phosphatase, Ser/Thr (non-receptor)
Chromosomal Location of Human Ortholog: 5q31.1
Cellular Component: cytosol; protein phosphatase type 2A complex
Molecular Function: protein binding
Biological Process: apoptosis; mitotic nuclear envelope reassembly; mRNA catabolic process, nonsense-mediated decay; protein amino acid dephosphorylation
Reference #:  P67775 (UniProtKB)
Alt. Names/Synonyms: PP2A-alpha; PP2AA; PP2Ac; PP2CA; PP2Calpha; PPP2CA; protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform; protein phosphatase 2, catalytic subunit, alpha isoform; protein phosphatase 2, catalytic subunit, alpha isozyme; protein phosphatase 2A catalytic subunit, alpha isoform; Replication protein C; RP-C; serine/threonine protein phosphatase 2A, catalytic subunit, alpha isoform; Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
Gene Symbols: PPP2CA
Molecular weight: 35,594 Da
Basal Isoelectric point: 5.3  Predict pI for various phosphorylation states
CST Pathways:  ESC Pluripotency and Differentiation  |  Growth And Differentiation Control by MAPKs  |  Insulin Receptor Signaling  |  PI3K/Akt Signaling  |  TGF-ß Signaling  |  Wnt/ß-Catenin Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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PPP2CA

Protein Structure Not Found.
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