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Protein Page:
PPP2CA (human)
rdtyret
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
PPP2CA ubiquitous cytosolic Ser/Thr protein phosphatase, catalytic subunit. The holoenzyme consists of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B'/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules. Note: This description may include information from UniProtKB.
Protein type: EC 3.1.3.16; Motility/polarity/chemotaxis; Protein phosphatase, Ser/Thr (non-receptor)
Chromosomal Location of Human Ortholog: 5q31.1
Cellular Component: chromosome, pericentric region; cytosol; membrane; microtubule cytoskeleton; mitochondrion; nucleus; plasma membrane; protein phosphatase type 2A complex; spindle pole
Molecular Function: GABA receptor binding; metal ion binding; phosphoprotein phosphatase activity; protein binding; protein C-terminus binding
Biological Process: apoptosis; ceramide metabolic process; fibroblast growth factor receptor signaling pathway; gene expression; inactivation of MAPK activity; meiotic cell cycle; mesoderm development; mitotic cell cycle; mitotic nuclear envelope reassembly; mRNA catabolic process, nonsense-mediated decay; negative regulation of cell growth; negative regulation of tyrosine phosphorylation of Stat3 protein; protein amino acid dephosphorylation; regulation of cell adhesion; regulation of cell differentiation; regulation of DNA replication; regulation of growth; regulation of transcription, DNA-dependent; regulation of Wnt receptor signaling pathway; response to organic substance; RNA splicing; second-messenger-mediated signaling
Reference #:  P67775 (UniProtKB)
Alt. Names/Synonyms: PP2A-alpha; PP2AA; PP2Ac; PP2CA; PP2Calpha; PPP2CA; protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform; protein phosphatase 2, catalytic subunit, alpha isoform; protein phosphatase 2, catalytic subunit, alpha isozyme; protein phosphatase 2A catalytic subunit, alpha isoform; Replication protein C; RP-C; serine/threonine protein phosphatase 2A, catalytic subunit, alpha isoform; Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
Gene Symbols: PPP2CA
Molecular weight: 35,594 Da
Basal Isoelectric point: 5.3  Predict pI for various phosphorylation states
CST Pathways:  ESC Pluripotency and Differentiation  |  Growth And Differentiation Control by MAPKs  |  Insulin Receptor Signaling  |  PI3K/Akt Signaling  |  TGF-ß Signaling  |  Wnt/ß-Catenin Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

PPP2CA

Protein Structure Not Found.


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Sites Implicated In
apoptosis, altered: Y307‑p
autophagy, inhibited: Y307‑p
cell growth, altered: T304‑p, Y307‑p
cytoskeletal reorganization: T304‑p, Y307‑p
translation, induced: Y307‑p
enzymatic activity, induced: L309‑me
enzymatic activity, inhibited: T304‑p, Y307‑p
intracellular localization: Y307‑p
methylation: Y307‑p
molecular association, regulation: T304‑p, Y307‑p

Modification Sites and Domains  
Click here to view other types of protein modifications

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 3 K4‑ac ____MDEkVFTkELD
0 1 K4‑ub ____MDEkVFTkELD
0 76 K8‑ub MDEkVFTkELDQWIE
0 126 K21‑ub IEQLNECkQLSEsQV
0 1 S26‑p ECkQLSEsQVkSLCE
0 1 K29‑ac QLSEsQVkSLCEkAK
0 17 K29‑ub QLSEsQVkSLCEkAK
0 5 K34‑ub QVkSLCEkAKEILTk
0 2 K41‑ac kAKEILTkESNVQEV
0 48 K41‑ub kAKEILTkESNVQEV
0 11 K74‑ub ELFRIGGkSPDTNYL
0 4 K136‑ub FYDECLRkYGNANVW
0 5 Y248‑p HQLVMEGyNWCHDRN
0 7 Y265‑p TIFSAPNyCYRCGNQ
0 28 K283‑ub MELDDTLkySFLQFD
0 19 Y284‑p ELDDTLkySFLQFDP
3 9 T304‑p EPHVTRRtPDyFl__
58 0 Y307‑p VTRRtPDyFl_____
7 0 L309‑me RRtPDyFl_______
  PPP2CA iso2  
K4 ____MDEKVFTKELD
K4 ____MDEKVFTKELD
K8 MDEKVFTKELDQWIE
K21 IEQLNECKQLSESQV
S26 ECKQLSESQVKSLCE
K29 QLSESQVKSLCEKAK
K29 QLSESQVKSLCEKAK
K34 QVKSLCEKAKEILTK
K41 KAKEILTKESNVQEV
K41 KAKEILTKESNVQEV
K74 ELFRIGGKSPDTNYL
K136 FYDECLRKYGNANVW
Y194 QEVPHEGYNWCHDRN
Y211 TIFSAPNYCYRCGNQ
K229 MELDDTLKYSFLQFD
Y230 ELDDTLKYSFLQFDP
T250 EPHVTRRTPDYFL__
Y253 VTRRTPDYFL_____
L255 RRTPDYFL_______
  mouse

 
K4 ____MDEKLFTkELD
K4 ____MDEKLFTkELD
K8‑ub MDEKLFTkELDQWIE
K21‑ub IEQLNECkQLSESQV
S26 ECkQLSESQVkSLCE
K29 QLSESQVKSLCEKAK
K29‑ub QLSESQVkSLCEKAK
K34 QVkSLCEKAKEILTk
K41‑ac KAKEILTkESNVQEV
K41‑ub KAKEILTkESNVQEV
K74‑ub ELFRIGGkSPDTNYL
K136‑ub FYDECLRkYGNANVW
Y248 HQLVMEGYNWCHDRN
Y265 TIFSAPNYCYRCGNQ
K283‑ub MELDDTLkySFLQFD
Y284‑p ELDDTLkySFLQFDP
T304‑p EPHVTRRtPDyFl__
Y307‑p VTRRtPDyFl_____
L309‑me RRtPDyFl_______
  rat

 
K4‑ac ____MDEkLFTkELD
K4 ____MDEKLFTkELD
K8‑ub MDEkLFTkELDQWIE
K21‑ub IEQLNECkQLSESQV
S26 ECkQLSESQVKSLCE
K29 QLSESQVKSLCEKAK
K29 QLSESQVKSLCEKAK
K34 QVKSLCEKAKEILTk
K41‑ac KAKEILTkESNVQEV
K41‑ub KAKEILTkESNVQEV
K74 ELFRIGGKSPDTNYL
K136 FYDECLRKYGNANVW
Y248‑p HQLVMEGyNWCHDRN
Y265 TIFSAPNYCYRCGNQ
K283‑ub MELDDTLkySFLQFD
Y284‑p ELDDTLkySFLQFDP
T304 EPHVTRRTPDyFl__
Y307‑p VTRRTPDyFl_____
L309‑me RRTPDyFl_______
  pig

 
K4 ____MDEKVFTKELD
K4 ____MDEKVFTKELD
K8 MDEKVFTKELDQWIE
K21 IEQLNECKQLSESQV
S26 ECKQLSESQVKSLCE
K29 QLSESQVKSLCEKAK
K29 QLSESQVKSLCEKAK
K34 QVKSLCEKAKEILTK
K41 KAKEILTKESNVQEV
K41 KAKEILTKESNVQEV
K74 ELFRIGGKSPDTNYL
K136 FYDECLRKYGNANVW
Y248 HQLVMEGYNWCHDRN
Y265 TIFSAPNYCYRCGNQ
K283 MELDDTLKYSFLQFD
Y284 ELDDTLKYSFLQFDP
T304 EPHVTRRTPDyFL__
Y307‑p VTRRTPDyFL_____
L309 RRTPDyFL_______
  cow

 
K4 ____MDEKVFTKELD
K4 ____MDEKVFTKELD
K8 MDEKVFTKELDQWIE
K21 IEQLNECKQLSESQV
S26 ECKQLSESQVKSLCE
K29 QLSESQVKSLCEKAK
K29 QLSESQVKSLCEKAK
K34 QVKSLCEKAKEILTK
K41 KAKEILTKESNVQEV
K41 KAKEILTKESNVQEV
K74 ELFRIGGKSPDTNYL
K136 FYDECLRKYGNANVW
Y248 HQLVMEGYNWCHDRN
Y265 TIFSAPNYCYRCGNQ
K283 MELDDTLKYSFLQFD
Y284 ELDDTLKYSFLQFDP
T304 EPHVTRRTPDyFl__
Y307‑p VTRRTPDyFl_____
L309‑me RRTPDyFl_______
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