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Protein Page:
DNAJC2 (human)

Overview
DNAJC2 Acts both as a chaperone in the cytosol and as a chromatin regulator in the nucleus. When cytosolic, acts as a molecular chaperone: component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, stimulates the ATPase activity of the ribosome-associated pool of Hsp70-type chaperones HSPA14 that bind to the nascent polypeptide chain. When nuclear, mediates the switching from polycomb- repressed genes to an active state: specifically recruited at histone H2A ubiquitinated at 'Lys-119' (H2AK119ub), and promotes the displacement of the polycomb PRC1 complex from chromatin, thereby facilitating transcription activation. Specifically binds DNA sequence 5'-GTCAAGC-3'. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation; Chaperone; DNA replication
Chromosomal Location of Human Ortholog: 7q22
Cellular Component: cytoplasm; cytosol; nuclear membrane; nucleoplasm; nucleus
Molecular Function: ATPase activator activity; chromatin binding; histone binding; Hsp70 protein binding; ubiquitin binding
Biological Process: 'de novo' cotranslational protein folding; positive regulation of transcription, DNA-dependent
Reference #:  Q99543 (UniProtKB)
Alt. Names/Synonyms: DnaJ (Hsp40) homolog, subfamily C, member 2; DnaJ homolog subfamily C member 2; DNAJC2; DNJC2; M-phase phosphoprotein 11; MPHOSPH11; MPP11; ZRF1; ZUO1; zuotin related factor 1; Zuotin-related factor 1
Gene Symbols: DNAJC2
Molecular weight: 71,996 Da
Basal Isoelectric point: 8.85  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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DNAJC2

Protein Structure Not Found.
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