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Protein Page:
HMGA2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
HMGA2 Functions as a transcriptional regulator. Functions in cell cycle regulation through CCNA2. Plays an important role in chromosome condensation during the meiotic G2/M transition of spermatocytes. Interacts with E4F1. Interacts with NEK2. Belongs to the HMGA family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Oncoprotein; DNA-binding
Chromosomal Location of Human Ortholog: 12q15
Cellular Component: nuclear chromosome; nucleoplasm; nucleus
Molecular Function: 5'-deoxyribose-5-phosphate lyase activity; AT DNA binding; DNA bending activity; DNA-(apurinic or apyrimidinic site) lyase activity; DNA-dependent protein kinase activity; nucleosomal DNA binding; protein binding; SMAD binding; transcription factor binding
Biological Process: base-excision repair; chondrocyte differentiation; chromosome breakage; DNA damage response, detection of DNA damage; epithelial to mesenchymal transition; establishment and/or maintenance of chromatin architecture; fat cell differentiation; heterochromatin formation; mesenchymal cell differentiation; mesodermal cell differentiation; mitotic cell cycle G2/M transition DNA damage checkpoint; multicellular organismal development; negative regulation of apoptosis; negative regulation of DNA binding; negative regulation of retroviral genome replication; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; positive regulation of apoptosis; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; regulation of transcription, DNA-dependent; response to virus; stem cell differentiation
Disease: Leiomyoma, Uterine
Reference #:  P52926 (UniProtKB)
Alt. Names/Synonyms: BABL; high mobility group AT-hook 2; High mobility group AT-hook protein 2; High mobility group protein HMGI-C; high-mobility group (nonhistone chromosomal) protein isoform I-C; High-mobility group protein HMGI-C; HMGA2; HMGI-C; HMGIC; LIPO; STQTL9
Gene Symbols: HMGA2
Molecular weight: 11,832 Da
Basal Isoelectric point: 10.63  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

HMGA2

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 3 S2‑p ______MsARGEGAG
0 1 S2‑ac ______MsARGEGAG
0 1 S12‑p GEGAGQPstsAQGQP
0 1 T13‑p EGAGQPstsAQGQPA
0 2 S14‑p GAGQPstsAQGQPAA
0 25 K26‑ac PAAPAPQkRGRGRPR
0 1 K26‑ub PAAPAPQkRGRGRPR
0 2 R27 AAPAPQkRGRGRPRK
0 3 T40‑p RKQQQEPtGEPsPKR
1 28 S44‑p QEPtGEPsPKRPRGR
1 2 S59‑p PKGSKNKsPSKAAQK
0 1 T97‑p KKPAQEEtEEtssQE
1 10 T100‑p AQEEtEEtssQEsAE
1 14 S101‑p QEEtEEtssQEsAEE
1 14 S102‑p EEtEEtssQEsAEED
1 31 S105‑p EEtssQEsAEED___
  HMGA2 iso2  
S2 ______MSARGEGAG
S2 ______MSARGEGAG
S12 GEGAGQPSTSAQGQP
T13 EGAGQPSTSAQGQPA
S14 GAGQPSTSAQGQPAA
K26 PAAPAPQKRGRGRPR
K26 PAAPAPQKRGRGRPR
R27 AAPAPQKRGRGRPRK
T40 RKQQQEPTGEPSPKR
S44 QEPTGEPSPKRPRGR
S59 PKGSKNKSPSKAAQK
- gap
- gap
- gap
- gap
- gap
  mouse

 
S2‑p ______MsARGEGAG
S2 ______MSARGEGAG
S12 GEGAGQPSTSAQGQP
T13 EGAGQPSTSAQGQPA
S14 GAGQPSTSAQGQPAA
K26‑ac PAAPVPQkrGRGRPR
K26 PAAPVPQKrGRGRPR
R27‑m1 AAPVPQkrGRGRPRK
T40 RKQQQEPTCEPsPKR
S44‑p QEPTCEPsPKRPRGR
S59‑p PKGSKNKsPSKAAQK
T96 QKKPAQETEEtssQE
T99‑p PAQETEEtssQEsAE
S100‑p AQETEEtssQEsAEE
S101‑p QETEEtssQEsAEED
S104‑p EEtssQEsAEED___
  rat

 
S2 ______MSARGEGAG
S2 ______MSARGEGAG
S12 GEGAGQPSTSAQGQP
T13 EGAGQPSTSAQGQPA
S14 GAGQPSTSAQGQPAT
K26 PATPAPQKRGRGRPR
K26 PATPAPQKRGRGRPR
R27 ATPAPQKRGRGRPRK
T40 RKQPQEPTCEPSPKR
S44 QEPTCEPSPKRPRGR
S59 PKGSKNKSPSKAAQK
T95 VQKPAQETEETSSQE
T98 PAQETEETSSQEsAE
S99 AQETEETSSQEsAEE
S100 QETEETSSQEsAEED
S103‑p EETSSQEsAEED___
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