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Protein Page:
CLIC4 (human)
rdtyret
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
CLIC4 Can insert into membranes and form poorly selective ion channels that may also transport chloride ions. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Promotes cell- surface expression of HRH3. Has alternate cellular functions like a potential role in angiogenesis or in maintaining apical- basolateral membrane polarity during mitosis and cytokinesis. Could also promote endothelial cell proliferation and regulate endothelial morphogenesis (tubulogenesis). Belongs to the chloride channel CLIC family. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 1p36.11
Cellular Component: actin cytoskeleton; apical part of cell; cell surface; centrosome; cytoplasm; cytoplasmic vesicle membrane; cytosol; intercellular junction; intracellular; microtubule cytoskeleton; microvillus; midbody; mitochondrion; nuclear matrix; perinuclear region of cytoplasm; plasma membrane
Molecular Function: chloride channel activity; glutathione transferase activity; protein binding; voltage-gated ion channel activity
Biological Process: angiogenesis; apoptosis; branching morphogenesis of a tube; cell differentiation; chloride transport; endothelial cell morphogenesis; establishment and/or maintenance of apical/basal cell polarity; fertilization; glutathione metabolic process; keratinocyte differentiation; multicellular organism growth; negative regulation of cell migration; regulation of cytoskeleton organization and biogenesis; vacuolar acidification
Reference #:  Q9Y696 (UniProtKB)
Alt. Names/Synonyms: chloride intracellular channel 4; chloride intracellular channel 4 like; Chloride intracellular channel protein 4; CLIC4; CLIC4L; DKFZp566G223; FLJ38640; H1; huH1; Intracellular chloride ion channel protein p64H1; MTCLIC; p64H1
Gene Symbols: CLIC4
Molecular weight: 28,772 Da
Basal Isoelectric point: 5.45  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

CLIC4

Protein Structure Not Found.


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Modification Sites and Domains  
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Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 S4‑p ____MALsMPLNGLk
0 4 K11‑ac sMPLNGLkEEDKEPL
0 1 K11 sMPLNGLKEEDKEPL
0 1 K62‑ub TTVDLKRkPADLQNL
0 5 K103‑ub EEVLCPPkYLKLsPK
0 1 K106 LCPPkYLKLsPKHPE
0 2 S108‑p PPkYLKLsPKHPESN
0 1 K110 kYLKLsPKHPESNTA
0 4 K130‑ac AKFSAYIkNSRPEAN
0 3 K130‑ub AKFSAYIkNSRPEAN
0 1 K146 ALERGLLKTLQKLDE
0 19 K146‑ub ALERGLLkTLQKLDE
0 1 K150 GLLkTLQKLDEYLNS
0 4 S167‑p PDEIDENsMEDIKFS
0 2 K194‑ub ADCNLLPkLHIVkVV
0 1 K199 LPkLHIVKVVAKKYR
0 41 K199‑ub LPkLHIVkVVAKKYR
0 1 K203 HIVkVVAKKYRNFDI
0 1 K212 YRNFDIPKEMTGIWR
0 2 K212‑ub YRNFDIPkEMTGIWR
0 1 Y220‑p EMTGIWRyLTNAYSR
0 3 S236‑p EFTNTCPsDKEVEIA
0 1 K238 TNTCPsDKEVEIAYS
0 1 K249 IAYSDVAKRLTK___
  mouse

 
S4 ____MALSMPLNGLk
K11 SMPLNGLKEEDKEPL
K11‑ub SMPLNGLkEEDKEPL
K62 TTVDLKRKPADLQNL
K103‑ub EEVLCPPkYLKLsPk
K106 LCPPkYLKLsPkHPE
S108‑p PPkYLKLsPkHPESN
K110‑ub kYLKLsPkHPESNTA
K130 AKFSAYIKNSRPEAN
K130‑ub AKFSAYIkNSRPEAN
K146 ALERGLLKTLQkLDE
K146‑ub ALERGLLkTLQkLDE
K150‑ub GLLkTLQkLDEYLNS
S167 PDEIDENSMEDIKFS
K194‑ub ADCNLLPkLHIVkVV
K199 LPkLHIVKVVAkKYR
K199‑ub LPkLHIVkVVAkKYR
K203‑ub HIVkVVAkKYRNFDI
K212 YRNFDIPKGMTGIWR
K212‑ub YRNFDIPkGMTGIWR
Y220 GMTGIWRYLTNAYSR
S236‑p EFTNTCPsDkEVEIA
K238‑ub TNTCPsDkEVEIAYS
K249‑ub IAYSDVAkRLTK___
  rat

 
S4 ____MALSMPLNGLK
K11 SMPLNGLKEEDKEPL
K11 SMPLNGLKEEDKEPL
K62 TTVDLKRKPAHLQNL
K103 EEVLCPPKYLkLSPK
K106‑ac LCPPKYLkLSPKHPE
S108 PPKYLkLSPKHPESN
K110 KYLkLSPKHPESNTA
K130‑ac AKFSAYIkNSRPEAN
K130 AKFSAYIKNSRPEAN
K146‑ac ALERGLLkTLQKLDE
K146 ALERGLLKTLQKLDE
K150 GLLkTLQKLDEYLNS
S167 PGEIDENSMEDIKSS
K194 ADCNLLPKLHIVkVV
K199‑ac LPKLHIVkVVAKKYR
K199‑ub LPKLHIVkVVAKKYR
K203 HIVkVVAKKYRNFDI
K212‑ac YRNFDIPkGMTGIWR
K212 YRNFDIPKGMTGIWR
Y220 GMTGIWRYLTNAYSR
S236 EFTNTCPSDKEVEIA
K238 TNTCPSDKEVEIAYS
K249 IAYSDVAKRLTK___
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