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Protein Page:
CLIC4 (human)

CLIC4 Can insert into membranes and form poorly selective ion channels that may also transport chloride ions. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Promotes cell- surface expression of HRH3. Has alternate cellular functions like a potential role in angiogenesis or in maintaining apical- basolateral membrane polarity during mitosis and cytokinesis. Could also promote endothelial cell proliferation and regulate endothelial morphogenesis (tubulogenesis). Belongs to the chloride channel CLIC family. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 1p36.11
Cellular Component: actin cytoskeleton; apical part of cell; cell surface; centrosome; cytoplasm; cytosol; intercellular junction; intracellular; microtubule cytoskeleton; microvillus; midbody; mitochondrion; nuclear matrix; perinuclear region of cytoplasm; plasma membrane
Molecular Function: glutathione transferase activity; protein binding
Biological Process: angiogenesis; cell differentiation; glutathione metabolic process; keratinocyte differentiation; negative regulation of cell migration
Reference #:  Q9Y696 (UniProtKB)
Alt. Names/Synonyms: chloride intracellular channel 4; chloride intracellular channel 4 like; Chloride intracellular channel protein 4; CLIC4; CLIC4L; DKFZp566G223; FLJ38640; H1; huH1; Intracellular chloride ion channel protein p64H1; MTCLIC; p64H1
Gene Symbols: CLIC4
Molecular weight: 28,772 Da
Basal Isoelectric point: 5.45  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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