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Protein Page:
BNIP3L (human)

Overview
BNIP3L Induces apoptosis. Interacts with viral and cellular anti-apoptosis proteins. Can overcome the suppressors BCL-2 and BCL-XL, although high levels of BCL-XL expression will inhibit apoptosis. Inhibits apoptosis induced by BNIP3. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates to mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. May function as a tumor suppressor. Self-associates. Interacts with BNIP3 and STEAP3. Interacts with SPATA18/MIEAP. Interacts with human adenovirus-2 E1B 19 kDa protein. Belongs to the NIP3 family. Note: This description may include information from UniProtKB.
Protein type: Apoptosis; Endoplasmic reticulum; Membrane protein, integral; Mitochondrial; Nuclear envelope
Chromosomal Location of Human Ortholog: 8p21
Cellular Component: endoplasmic reticulum; intrinsic to membrane; mitochondrial outer membrane; mitochondrion; nuclear envelope
Molecular Function: identical protein binding; lamin binding; protein binding; protein heterodimerization activity; protein homodimerization activity
Biological Process: defense response to virus; negative regulation of apoptosis; positive regulation of apoptosis; positive regulation of macroautophagy; regulation of apoptosis
Reference #:  O60238 (UniProtKB)
Alt. Names/Synonyms: Adenovirus E1B19K-binding protein B5; BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like; BCL2/adenovirus E1B 19 kDa protein-interacting protein 3A; BCL2/adenovirus E1B 19-kd protein-interacting protein 3a; BCL2/adenovirus E1B 19kDa interacting protein 3-like; BNI3L; BNIP3A; BNIP3H; BNIP3L; NIP3-like protein X; NIP3L; NIX
Gene Symbols: BNIP3L
Molecular weight: 23,930 Da
Basal Isoelectric point: 5.52  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

BNIP3L

Protein Structure Not Found.


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