Apoptosis-inducing protein that, which can overcome BCL2 suppression. May play a role in repartitioning calcium between the two major intracellular calcium stores in association with BCL2. Homodimer. Binds to BCL2. Interacts with BNIP3L and ACAA2. Also can interact with adenovirus E1B 19 kDa protein or Epstein-Barr virus BHRF1. Belongs to the NIP3 family. Note: This description may include information from UniProtKB.
Protein type: Mitochondrial; Membrane protein, integral
Cellular Component: cytoplasm; dendrite; endoplasmic reticulum; integral to membrane; integral to mitochondrial outer membrane; membrane; mitochondrial envelope; mitochondrial membrane; mitochondrial outer membrane; mitochondrion; nuclear envelope; nucleoplasm; nucleus
Molecular Function: GTPase binding; identical protein binding; protein binding; protein heterodimerization activity; protein homodimerization activity
Biological Process: apoptosis; autophagic cell death; brown fat cell differentiation; cell death; defense response to virus; induction of apoptosis by granzyme; mitochondrial fragmentation during apoptosis; negative regulation of apoptosis; negative regulation of membrane potential; neuron apoptosis; positive regulation of apoptosis; positive regulation of macroautophagy; positive regulation of programmed cell death; positive regulation of protein complex disassembly; regulation of mitochondrial membrane permeability; response to hypoxia
LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.