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Protein Page:
APOA5 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
APOA5 Minor apolipoprotein mainly associated with HDL and to a lesser extent with VLDL. May also be associated with chylomicrons. Important determinant of plasma triglyceride (TG) levels by both being a potent stimulator of apo-CII lipoprotein lipase (LPL) TG hydrolysis and a inhibitor of the hepatic VLDL-TG production rate (without affecting the VLDL-apoB production rate). Activates poorly lecithin:cholesterol acyltransferase (LCAT) and does not enhance efflux of cholesterol from macrophages. Interacts with GPIHBP1. Up-regulated by PPARA agonists, which are used clinically to lower serum TG (such as fibrates). Liver and plasma. Belongs to the apolipoprotein A1/A4/E family. Note: This description may include information from UniProtKB.
Protein type: Lipid-binding; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 11q23
Cellular Component: chylomicron; extracellular region; extracellular space
Molecular Function: cholesterol binding; cholesterol transporter activity; enzyme activator activity; enzyme binding; heparin binding; lipid binding; low-density lipoprotein receptor binding; phosphatidylcholine binding; phospholipid binding
Biological Process: acylglycerol homeostasis; cholesterol biosynthetic process; cholesterol efflux; cholesterol homeostasis; lipid transport; lipoprotein metabolic process; neurite regeneration; phosphatidylcholine metabolic process; phospholipid efflux; positive regulation of fatty acid biosynthetic process; positive regulation of lipid catabolic process; positive regulation of lipoprotein lipase activity; positive regulation of receptor-mediated endocytosis; regulation of cholesterol absorption; reverse cholesterol transport; tissue regeneration; triacylglycerol catabolic process; triacylglycerol metabolic process
Disease: Hyperlipoproteinemia, Type V; Hypertriglyceridemia, Familial
Reference #:  Q6Q788 (UniProtKB)
Alt. Names/Synonyms: Apo-AV; ApoA-V; APOA5; APOAV; Apolipoprotein A-V; Apolipoprotein A5; FLJ97995; MGC126836; MGC126838; RAP3; Regeneration-associated protein 3
Gene Symbols: APOA5
Molecular weight: 41,213 Da
Basal Isoelectric point: 5.98  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

APOA5

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K48 VEQIHQQKMAREPAt
0 1 T55‑p KMAREPAtLKDsLEQ
0 7 S59‑p EPAtLKDsLEQDLNN
0 1 - gap
0 1 S80‑ga KLRPLSGsEAPRLPQ
0 1 R94 QDPVGMRRQLQEELE
0 1 K188 VHHTGRFKELFHPYA
0 1 S220 VAPHAPASPARLSRC
0 2 - gap
0 1 S361 SLHDQGHSHLGDP__
0 1 - gap
  mouse

 
K43‑ub GVMGQPQkLAQENLK
N48 PQkLAQENLKGsFEQ
S52‑p AQENLKGsFEQDLyN
Y58‑p GsFEQDLyNMNNYLE
- gap
K89‑ub QDPEGIRkQLQQELG
K183‑ub LHHTDRVkELFHPYA
S215‑p VAPHAAAsPARLSRC
S339‑p KALSRLQsRLDDLWE
S358‑p GLQDQGHsHLsDPEG
S361‑p DQGHsHLsDPEGHSG
  rat

 
K43 GMMGQQQKLAQESLK
S48 QQKLAQESLKGsLEQ
S52‑p AQESLKGsLEQDLYN
Y58 GsLEQDLYNMNNFLE
- gap
K89 QDPEGIRKQLQQELE
K183 LHHTDRVKELFHPYA
S215 VAPHAVASPARLSRC
S339 KALSRLQSRLDDLWE
S358 GLHDQGHSQNNPEGH
- gap
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