Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
logos LINCs Logo Mt Sinai Logo NIH Logo NCI Logo
Protein Page:
GCN2 (human)
rdtyret
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
GCN2 a kinase of the PEK family. Phosphorylates and inhibits eukaryotic initiation factor (eIF)-2 alpha, providing an important protective mechanism during various cellular stress conditions including endoplasmic reticulum (ER) stress. Note: This description may include information from UniProtKB.
Protein type: Translation; EC 2.7.11.1; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, Other; Other group; PEK family; GCN2 subfamily
Chromosomal Location of Human Ortholog: 15q15.1
Cellular Component: polysome
Molecular Function: ATP binding; eukaryotic translation initiation factor 2alpha kinase activity; protein serine/threonine kinase activity; tRNA binding
Biological Process: cellular response to amino acid starvation; inhibition of CREB transcription factor; learning; long-term memory; negative regulation of neuron differentiation; negative regulation of translation initiation in response to stress; negative regulation of translational initiation; positive regulation of adaptive immune response; positive regulation of defense response to virus by host; protein amino acid autophosphorylation; protein amino acid phosphorylation; regulation of translational initiation; T cell activation during immune response; unfolded protein response; viral protein biosynthetic process
Disease: Pulmonary Venoocclusive Disease 2, Autosomal Recessive
Reference #:  Q9P2K8 (UniProtKB)
Alt. Names/Synonyms: E2AK4; EIF2AK4; eukaryotic translation initiation factor 2 alpha kinase 4; Eukaryotic translation initiation factor 2-alpha kinase 4; GCN2; GCN2 eIF2alpha kinase; GCN2-like protein; KIAA1338
Gene Symbols: EIF2AK4
Molecular weight: 186,911 Da
Basal Isoelectric point: 5.88  Predict pI for various phosphorylation states
CST Pathways:  Translation: eIF2
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

GCN2

Protein Structure Not Found.


STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Scansite  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein


Sites Implicated In
apoptosis, induced: T899‑p
molecular association, regulation: T899‑p
protein stabilization: T899‑p

Modification Sites and Domains  
Click here to view other types of protein modifications

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S102‑p AKGLSNEsVNLLKSR
0 1 S207‑p RLEIASLsNQDHTSK
1 13 S230‑p AAILHGGsPDFVGNG
0 2 Y253‑p RSRRERQysVCNSED
0 18 S254‑p SRRERQysVCNSEDs
0 2 S261‑p sVCNSEDsPGSCEIL
0 1 Y269‑p PGSCEILyFNMGSPD
0 1 T438 VLVDAEGTVKITDYS
0 2 S467‑p EQTRVRFsDNALPYK
0 2 Y500‑p QGQECGEyPVTIPSD
1 7 S551‑p KMPLVEQsPEDsEGQ
0 6 S555‑p VEQsPEDsEGQDyVE
0 3 Y560‑p EDsEGQDyVETVIPS
0 1 S572‑p IPSNRLPsAAFFSET
0 1 K606‑ac GAFGAVIkVQNKLDG
0 1 K634‑ub SRQFRRIkGEVTLLS
0 16 T667‑p ERPAGPGtPPPDsGP
0 3 S672‑p PGtPPPDsGPLAKDD
0 1 S770‑p NEDENSKsQNQDEDC
0 1 T871‑p IGDFGLAtDHLAFSA
2 0 T899‑p SDPSGHLtGMVGTAL
0 1 S928‑p NQKVDLFsLGIIFFE
0 1 T991‑p HDPAKRPtATELLKS
0 1 T1085‑p HGAVQLCtPLLLPRN
0 4 K1259‑ac NSLCRLYkFIEQKGD
  mouse

 
S102 AKGLSNESVNLLKSH
T207 RLEITSLTNQDYASK
S230‑p AAILHGGsPDFVGNG
Y253 RSRRERQYsVCSGEP
S254‑p SRRERQYsVCSGEPs
S261‑p sVCSGEPsPGSCDIL
H269 PGSCDILHFSVGSPD
T437‑p VLVDAEGtVKITDYS
S466 EQARVRFSDSALPYK
Y499 QGQECGEYPVTIPSD
S550‑p KLPLVEQsPEDSGGQ
S554 VEQsPEDSGGQDyIE
Y559‑p EDSGGQDyIETVIPS
S571 IPSNQLPSAAFFSET
K605 GAFGAVIKVQNKLDG
K633 SRHFRRIKGEVTLLS
T666 ERPAVPGTPPPDCTP
C671 PGTPPPDCTPQAQDS
S768 NEDENSKSQNQDEDC
T869 IGDFGLATDHLAFTA
T898‑p SDPSGHLtGMVGTAL
S927 NQKVDLFSLGIIFFE
T990 HDPAKRPTAMELLKS
T1084 HGAVQLCTPLLLPRN
K1258 NSLCRLYKFIEQKGD
  rat

 
S102 TKGLSNESVNLLKSH
T207 RLEITSLTNQDHASK
S230 AAILHGGSPDFVGNG
Y253 RSRRERQYSVCSGEA
S254 SRRERQYSVCSGEAS
S261 SVCSGEASPGSCDIL
Y269 PGSCDILYFCVGSAD
T438 VLVDAEGTVKITDYS
S467 EQTRVRFSDSALPYK
Y500 QGQECEEYPVTIPSD
S551 KMPLVEQSPEDSGGQ
S555 VEQSPEDSGGQDYIE
Y560 EDSGGQDYIETIIPS
S572 IPSNQLPSAAFFTET
K606 GAFGAVIKVQNKLDG
K634 SRQFRRIKGEVTLLS
T667‑p ERPAVPGtPPPDYIP
Y672 PGtPPPDYIPQAQNS
S769 NEDENSKSQNQDEDC
T870 IGDFGLATDHLAFNA
T899 SDPSGHLTGMVGTAL
S928 NQKVDLFSLGIILFE
T991 HDPAKRPTAMELLKS
T1085 HGAVQLCTPLLLPRN
K1259‑ac NSLCRLYkFIEQKGD
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.