a kinase of the PEK family. Phosphorylates and inhibits eukaryotic initiation factor (eIF)-2 alpha, providing an important protective mechanism during various cellular stress conditions including endoplasmic reticulum (ER) stress. Note: This description may include information from UniProtKB.
Protein type: Kinase, protein; Translation; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); EC 220.127.116.11; Other group; PEK family; GCN2 subfamily
Molecular Function: ATP binding; eukaryotic translation initiation factor 2alpha kinase activity; protein serine/threonine kinase activity; tRNA binding
Biological Process: adaptive immune response; cell cycle arrest; cellular response to amino acid starvation; defense response to virus; inhibition of CREB transcription factor; learning; long-term memory; negative regulation of neuron differentiation; negative regulation of translation initiation in response to stress; negative regulation of translational initiation; positive regulation of adaptive immune response; positive regulation of defense response to virus by host; protein amino acid autophosphorylation; protein amino acid phosphorylation; regulation of translational initiation; T cell activation during immune response; viral protein biosynthetic process
LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.