Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
HomeAbout PhosphoSiteUsing PhosphoSiteprivacy & cookiesCuration ProcessContact
logos LINCs Logo Mt Sinai Logo NIH Logo NCI Logo
Protein Page:
TMPO iso6 (human)

TMPO iso6 a single-pass type II membrane protein. Tightly associated with the nuclear lamina. Binds DNA and involved in DNA replication and chromatin remodeling, May help direct the assembly of the nuclear lamina and thereby help maintain the structural organization of the nuclear envelope. Possible receptor for attachment of lamin filaments to the inner nuclear membrane. May be involved in the control of initiation of DNA replication through its interaction with HAP95. Associated with dilated cardiomyopathy; upregulated in medulloblastoma. Used as a pharmaceutical to treat primary and secondary immune deficiencies, autoimmunity, infections and cancer. Available under the names Timunox (Cilag), Sintomodulina (Italofarmaco) and Mepentil (Recordati). Three alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Membrane protein, integral
Chromosomal Location of Human Ortholog: 12q22
Cellular Component: cell-cell adherens junction; chromatin; nuclear envelope; nucleus
Molecular Function: lamin binding
Disease: Cardiomyopathy, Dilated, 1t
Reference #:  P42166 (UniProtKB)
Alt. Names/Synonyms: CMD1T; lamina-associated polypeptide 2; Lamina-associated polypeptide 2, isoform alpha; LAP2; LAP2A; LEM domain containing 4; LEMD4; MGC61508; PRO0868; Splenin; Thymopentin; Thymopoietin; Thymopoietin isoform alpha; thymopoietin-related peptide; Thymopoietin-related peptide isoform alpha; TMPO; TP; TP alpha; TP beta/gamma; TP5; TPRP isoform alpha
Gene Symbols: TMPO
Molecular weight: 75,492 Da
Basal Isoelectric point: 7.56  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

TMPO iso6

Protein Structure Not Found.
Download PyMol Script
Download ChimeraX Script

cBioPortal  |  Wikipedia  |  Scansite  |  Pfam  |  RCSB PDB  |  Phospho3D  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene