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Protein Page:
FZD6 (human)

FZD6 Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK- 3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Detected in adult heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, thymus, prostate, testis, ovary, small intestine and colon. In the fetus, expressed in brain, lung, liver and kidney. Belongs to the G-protein coupled receptor Fz/Smo family. Note: This description may include information from UniProtKB.
Protein type: GPCR, Fz/Smo family; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR
Chromosomal Location of Human Ortholog: 8q22.3-q23.1
Cellular Component: integral to membrane; integral to plasma membrane; plasma membrane
Molecular Function: G-protein coupled receptor activity; protein binding; ubiquitin protein ligase binding; Wnt receptor activity; Wnt-protein binding
Biological Process: negative regulation of transcription factor activity; Wnt receptor signaling pathway, calcium modulating pathway
Disease: Nail Disorder, Nonsyndromic Congenital, 10
Reference #:  O60353 (UniProtKB)
Alt. Names/Synonyms: frizzled homolog 6 (Drosophila); Frizzled-6; Fz-6; FZ6; FZD6; hFz6
Gene Symbols: FZD6
Molecular weight: 79,292 Da
Basal Isoelectric point: 8.29  Predict pI for various phosphorylation states
CST Pathways:  ESC Pluripotency and Differentiation  |  mTOR Signaling  |  Translation: eIF4E and p70S6K  |  Wnt/ß-Catenin Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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