Probable transcription factor associated with development of alveolar rhabdomyosarcoma. Can bind to DNA as a heterodimer with PAX7. Interacts with DAXX. Belongs to the paired homeobox family. 7 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Transcription factor; Oncoprotein; DNA-binding
Molecular Function: chromatin binding; protein binding; RNA polymerase II transcription factor activity, enhancer binding; sequence-specific DNA binding; transcription factor activity
Biological Process: apoptosis; cell proliferation; establishment and/or maintenance of chromatin architecture; heart development; negative regulation of transcription from RNA polymerase II promoter; neural crest cell migration; neural tube closure; neuron fate commitment; organ morphogenesis; pigmentation during development; positive regulation of cell proliferation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; regulation of somitogenesis; sensory perception of sound; spinal cord association neuron differentiation; transcription from RNA polymerase II promoter
LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.