Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
HomeAbout PhosphoSiteUsing PhosphoSiteprivacy & cookiesCuration ProcessContact
logos LINCs Logo Mt Sinai Logo NIH Logo NCI Logo
Protein Page:
EIF4E (mouse)

EIF4E a protein of the eukaryotic initiation factor 4E family. Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. Phosphorylation increases the ability of the protein to bind to mRNA caps and to form the EIF4F complex. Note: This description may include information from UniProtKB.
Protein type: Translation; Translation initiation
Cellular Component: cytoplasm; eukaryotic translation initiation factor 4F complex; mRNA cap complex; perinuclear region of cytoplasm; protein complex; stress granule
Molecular Function: enzyme binding; eukaryotic initiation factor 4G binding; protein binding; translation initiation factor activity
Biological Process: behavioral fear response; G1/S transition of mitotic cell cycle; negative regulation of neuron differentiation; negative regulation of translation; positive regulation of mitotic cell cycle; regulation of translation; stem cell maintenance
Reference #:  P63073 (UniProtKB)
Alt. Names/Synonyms: EG668879; eIF-4E; eIF-4F 25 kDa subunit; Eif4e; Eif4e-ps; Eukaryotic translation initiation factor 4E; If4e; MGC103177; mRNA cap-binding protein
Gene Symbols: Eif4e
Molecular weight: 25,053 Da
Basal Isoelectric point: 5.79  Predict pI for various phosphorylation states
CST Pathways:  Angiogenesis  |  Insulin Receptor Signaling  |  Translation: eIF4E and p70S6K  |  Translational Control
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below


Protein Structure Not Found.
Download PyMol Script
Download ChimeraX Script

STRING  |  Reactome  |  BioGPS  |  Scansite  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene