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Protein Page:
Bcl-10 (human)
rdtyret
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
Bcl-10 a ubiquitous pro-apoptotic protein that promotes pro-caspase-9 maturation and activation of NF-kappa-B via NIK and IKK. May be an adapter protein between upstream TNFR1-TRADD-RIP complex and the downstream NIK-IKK-IKAP complex. Self-associates via CARD-CARD interactions; forms a tight complex with MALT1. Interacts with other CARD-proteins such as CARD9, CARD10, CARD11 and CARD14. Binds caspase-9 with its C-terminal domain. Interacts with TRAF2 and BIRC2/c-IAP2. Defects in BCL10 are involved in various types of cancer. Note: This description may include information from UniProtKB.
Protein type: Tumor suppressor; Apoptosis; Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 1p22
Cellular Component: CBM complex; cytoplasm; cytoplasmic microtubule; cytosol; immunological synapse; lipid raft; lipopolysaccharide receptor complex; lysosome; nucleus; perinuclear region of cytoplasm; plasma membrane; protein complex; T cell receptor complex
Molecular Function: enzyme binding; kinase activator activity; kinase binding; NF-kappaB binding; protease binding; protein binding; protein C-terminus binding; protein kinase B binding; protein kinase binding; protein self-association; transcription coactivator activity; transcription factor binding; ubiquitin binding; ubiquitin protein ligase binding
Biological Process: activation of NF-kappaB transcription factor; adaptive immune response; B cell apoptosis; cell death; cellular defense response; immunoglobulin mediated immune response; innate immune response; interleukin-6 biosynthetic process; lymphotoxin A biosynthetic process; negative regulation of mature B cell apoptosis; neural tube closure; positive regulation of caspase activity; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of interleukin-8 biosynthetic process; positive regulation of mast cell cytokine production; positive regulation of phosphorylation; positive regulation of protein ubiquitination; positive regulation of T cell activation; positive regulation of transcription, DNA-dependent; protein heterooligomerization; protein homooligomerization; protein oligomerization; regulation of T cell receptor signaling pathway; response to food; response to fungus; response to molecule of bacterial origin; stimulatory C-type lectin receptor signaling pathway; T cell receptor signaling pathway; toll-like receptor signaling pathway
Disease: Follicular Lymphoma, Susceptibility To, 1; Gastric Lymphoma, Primary; Immunodeficiency 37; Lymphoma, Non-hodgkin, Familial; Mesothelioma, Malignant; Testicular Germ Cell Tumor
Reference #:  O95999 (UniProtKB)
Alt. Names/Synonyms: B-cell CLL/lymphoma 10; B-cell lymphoma/leukemia 10; Bcl-10; BCL10; c-E10; CARD containing molecule enhancing NF-kB; CARD-containing apoptotic signaling protein; CARD-containing molecule enhancing NF-kappa-B; CARD-containing proapoptotic protein; CARD-like apoptotic protein; CARMEN; caspase-recruiting domain-containing protein; cCARMEN; CED-3/ICH-1 prodomain homologous E10-like regulator; Cellular homolog of vCARMEN; Cellular-E10; CIPER; CLAP; hCLAP; Mammalian CARD-containing adapter molecule E10; mE10
Gene Symbols: BCL10
Molecular weight: 26,252 Da
Basal Isoelectric point: 5.57  Predict pI for various phosphorylation states
CST Pathways:  B Cell Receptor Signaling  |  T Cell Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

Bcl-10

Protein Structure Not Found.


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Sites Implicated In
cell motility, altered: S138‑p
cytoskeletal reorganization: S138‑p
transcription, altered: S138‑p
intracellular localization: S218‑p, S231‑p
molecular association, regulation: S134‑p, S218‑p, S231‑p
phosphorylation: S138‑p

Modification Sites and Domains  
Click here to view other types of protein modifications

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 T4‑p ____MEPtAPSLTEE
1 0 K31‑ub LRVYLCEkIIAERHF
1 12 T52‑p KILSREDtEEISCRT
0 1 T59 tEEISCRTSSRkRAG
0 1 S60 EEISCRTSSRkRAGK
0 1 S61 EISCRTSSRkRAGKL
1 0 K63‑ub SCRTSSRkRAGKLLD
0 1 S85‑p GLDTLVEsIRREKTQ
0 1 T100‑p NFLIQKItDEVLKLR
0 1 S120 HLKGLKCSSCEPFPD
0 1 S121 LKGLKCSSCEPFPDG
0 2 T130‑p EPFPDGAtNNLsRsN
3 9 S134‑p DGAtNNLsRsNsDEs
1 2 S136‑p AtNNLsRsNsDEsNF
7 37 S138‑p NNLsRsNsDEsNFsE
1 4 S141‑p sRsNsDEsNFsEKLR
1 3 S144‑p NsDEsNFsEKLRAST
0 2 T163‑p PEGESSTtPFFSTNs
1 0 S170‑p tPFFSTNssLNLPVL
1 0 S171‑p PFFSTNssLNLPVLE
3 0 S218‑p EEGTCANsSEMFLPL
0 1 S227‑p EMFLPLRsRtVsRQ_
0 1 T229‑p FLPLRsRtVsRQ___
1 1 S231‑p PLRsRtVsRQ_____
  mouse

 
P4 ____MEAPAPSLTEE
K31 LRVYLCEKIIAERHF
T52‑p KILSREDtEEISCRt
T59‑p tEEISCRtssRKRAG
S60‑p EEISCRtssRKRAGK
S61‑p EISCRtssRKRAGKL
K63 SCRtssRKRAGKLLD
S85 GLDTLVESIRREKTQ
T100 SFLIQKITDEVLKLR
S120‑p HLKGLKCssCEPFAA
S121‑p LKGLKCssCEPFAAG
T130‑p EPFAAGAtNNLsRCN
S134‑p AGAtNNLsRCNsDEs
C136 AtNNLsRCNsDEsNL
S138‑p NNLsRCNsDEsNLsE
S141‑p sRCNsDEsNLsEKQR
S144‑p NsDEsNLsEKQRAST
A163 PEGESSTAPFFSMAS
S170 APFFSMASSLNLPVL
S171 PFFSMASSLNLPVLE
S218 EGGSCGNSSEMFLPL
S227 EMFLPLRSRALSRQ_
A229 FLPLRSRALSRQ___
S231 PLRSRALSRQ_____
  rat

 
P4 ____MEAPAPSLTEE
K31 LRVYLCEKIIAERHF
T52 KILSREDTEEISCRT
T59 TEEISCRTSSRKRAG
S60 EEISCRTSSRKRAGK
S61 EISCRTSSRKRAGKL
K63 SCRTSSRKRAGKLLD
S85 GLDTLVESIRREKTQ
T100 NFLIQKITDEVLKLR
S120 HLKGLKCSSCEPFAA
S121 LKGLKCSSCEPFAAG
T130 EPFAAGATNNLSRSN
S134 AGATNNLSRSNsDES
S136 ATNNLSRSNsDESNF
S138‑p NNLSRSNsDESNFSE
S141 SRSNsDESNFSEKQR
S144 NsDESNFSEKQRPST
A163 PEGESSTAPFFSTES
S170 APFFSTESSLNLPVL
S171 PFFSTESSLNLPVLE
S218 EGGSCGNSSEMFLPL
S227 EMFLPLRSRALSRQ_
A229 FLPLRSRALSRQ___
S231 PLRSRALSRQ_____
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