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Protein Page:
STAT1 (mouse)
rdtyret
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
STAT1 transcription factor of the STAT family. Phosphorylated and activated by receptor-associated kinases downstream of certain receptor tyrosine kinases, GPCRs, and receptors for various interleukins and interferons. Forms homo- or heterodimers that translocate into the nucleus where they regulate transcription. Two alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Transcription factor; DNA-binding
Cellular Component: axon; cytoplasm; dendrite; nuclear chromatin; nucleolus; nucleoplasm; nucleus; perinuclear region of cytoplasm
Molecular Function: CCR5 chemokine receptor binding; DNA binding; double-stranded DNA binding; enzyme binding; identical protein binding; protein binding; protein homodimerization activity; protein phosphatase 2A binding; sequence-specific DNA binding; signal transducer activity; transcription factor activity; tumor necrosis factor receptor binding
Biological Process: blood circulation; caspase activation; cellular response to insulin stimulus; cytokine and chemokine mediated signaling pathway; JAK-STAT cascade; lipopolysaccharide-mediated signaling pathway; negative regulation of angiogenesis; negative regulation of endothelial cell proliferation; negative regulation of I-kappaB kinase/NF-kappaB cascade; negative regulation of viral protein levels in host cell; positive regulation of cell proliferation; positive regulation of smooth muscle cell proliferation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; regulation of transcription, DNA-dependent; response to bacterium; response to cAMP; response to cytokine stimulus; response to drug; response to exogenous dsRNA; response to lipopolysaccharide; response to mechanical stimulus; response to nutrient; response to peptide hormone stimulus; signal transduction; transcription, DNA-dependent; tumor necrosis factor-mediated signaling pathway
Reference #:  P42225 (UniProtKB)
Alt. Names/Synonyms: 2010005J02Rik; AA408197; Signal transducer and activator of transcription 1; Stat1
Gene Symbols: Stat1
Molecular weight: 87,197 Da
Basal Isoelectric point: 5.42  Predict pI for various phosphorylation states
CST Pathways:  ErbB/HER Signaling  |  Growth And Differentiation Control by MAPKs  |  IL6 Signaling  |  Inhibition of Apoptosis  |  Regulation of P38 MAPKs
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

STAT1

Protein Structure Not Found.


STRING  |  Reactome  |  BioGPS  |  Scansite  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene


Sites Implicated In
cell cycle regulation: S727‑p
cell growth, altered: Y701‑p, S727‑p
transcription, altered: S708‑p, S727‑p
transcription, induced: Y701‑p, S727‑p
activity, induced: S727‑p
intracellular localization: Y701‑p
molecular association, regulation: Y701‑p, S727‑p
phosphorylation: Y701‑p
protein degradation: S727‑p

Modification Sites and Domains  
Click here to view other types of protein modifications

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       mouse

 
2 0 R31 DSFPMEIRQYLAQWL
1 0 R31 DSFPMEIRQYLAQWL
0 1 K40 YLAQWLEKQDWEHAA
0 12 Y68 LSQLDDQYSRFSLEN
0 19 Y106 VQMSMIIYNCLKEER
0 2 K138‑ub QNTVMLDkQKELDSK
0 1 T162 CIEQEIKTLEELQDE
0 3 Y170 LEELQDEYDFKCKTS
0 1 K173 LQDEYDFKCKTSQNR
0 2 K173 LQDEYDFKCKTSQNR
0 1 A184 SQNREGEANGVAKSD
0 6 K193‑ub GVAKSDQkQEQLLLH
0 1 F203 QLLLHKMFLMLDNKR
0 1 K209 MFLMLDNKRKEIIHK
0 1 K216 KRKEIIHKIRELLNS
0 1 S223 KIRELLNSIELTQNT
0 1 T227 LLNSIELTQNTLIND
0 3 K240 NDELVEWKRRQQSAC
0 7 K296‑ub YEPDPITkNKQVLSD
0 1 K298 PDPITkNKQVLSDRT
0 2 K375 VNEKNTVKGFRkFNI
0 1 K379 NTVKGFRKFNILGTH
0 1 K379‑ub NTVKGFRkFNILGTH
3 2 K410 ELRHLQLKEQKNAGN
0 11 K410 ELRHLQLKEQKNAGN
3 1 K413 HLQLKEQKNAGNRTN
0 1 N417 KEQKNAGNRTNEGPL
0 5 K511 WQFSSVTKRGLNADQ
0 2 K525‑ub QLSMLGEkLLGPNAG
0 6 G532 kLLGPNAGPDGLIPW
0 2 K544‑ub IPWTRFCkENINDKN
0 1 S583 GCIMGFISKERERAL
0 13 K592‑ub ERERALLkDQQPGTF
0 1 K636 HAVEPYTKkELSAVT
0 1 K637‑ub AVEPYTKkELSAVTF
0 1 S640 PYTKkELSAVTFPDI
0 15 K652‑ub PDIIRNYkVMAAENI
0 2 K665‑ub NIPENPLkYLYPNID
0 4 Y668 ENPLkYLYPNIDkDH
0 1 K673‑ub YLYPNIDkDHAFGkY
0 1 K679‑ub DkDHAFGkYYSRPKE
0 5 T699 ELDDPKRTGyIKTEL
130 55 Y701‑p DDPKRTGyIKTELIs
6 1 K703 PKRTGyIKTELIsVS
0 3 T704 KRTGyIKTELIsVSE
2 0 S708‑p yIKTELIsVSEVHPS
0 2 T719‑p VHPSRLQttDNLLPM
0 1 T720‑p HPSRLQttDNLLPMs
79 100 S727‑p tDNLLPMsPEEFDEM
0 1 S735‑p PEEFDEMsRIVGPEF
1 0 S744‑p IVGPEFDsMMsTV__
1 0 S747‑p PEFDsMMsTV_____
5167 : Phospho-Stat1 (Tyr701) (58D6) Rabbit mAb (Sepharose Bead Conjugate)
5375 : Phospho-Stat1 (Tyr701) (58D6) Rabbit mAb (Biotinylated)
7649 : Phospho-Stat1 (Tyr701) (D4A7) Rabbit mAb
8009 : Phospho-Stat1 (Tyr701) (58D6) Rabbit mAb (Alexa Fluor(R) 647 Conjugate)
8062 : Phospho-Stat1 (Tyr701) (58D6) Rabbit mAb (PE Conjugate)
8183 : Phospho-Stat1 (Tyr701) (58D6) Rabbit mAb (Alexa Fluor(R) 555 Conjugate)
9167 : Phospho-Stat1 (Tyr701) (58D6) Rabbit mAb
9171 : Phospho-Stat1 (Tyr701) Antibody
9174 : Phospho-Stat1 (Tyr701) (58D6) Rabbit mAb (Alexa Fluor(R) 488 Conjugate)
8826 : Phospho-Stat1 (Ser727) (D3B7) Rabbit mAb
9177 : Phospho-Stat1 (Ser727) Antibody
  human

► Hide Isoforms
 
R31‑m1 DSFPMEIrQYLAQWL
R31‑m2 DSFPMEIrQYLAQWL
K40‑ub YLAQWLEkQDWEHAA
Y68‑p LSQLDDQySRFSLEN
Y106‑p IQMSMIIySCLKEER
K138‑ub QSTVMLDkQKELDSK
S162‑p CIEHEIKsLEDLQDE
Y170‑p LEDLQDEyDFkCKTL
K173‑ac LQDEyDFkCKTLQNR
K173‑ub LQDEyDFkCKTLQNR
T184‑p LQNREHEtNGVAKSD
K193‑ub GVAKSDQkQEQLLLK
Y203‑p QLLLKKMyLMLDNkR
K209‑ub MyLMLDNkRKEVVHK
K216 kRKEVVHKIIELLNV
V223 KIIELLNVTELTQNA
T227 LLNVTELTQNALIND
K240‑ub NDELVEWkRRQQSAC
K296‑ub YEHDPITkNkQVLWD
K298‑ub HDPITkNkQVLWDRT
K375‑ub VNERNTVkGFRKFNI
K379 NTVkGFRKFNILGTH
K379 NTVkGFRKFNILGTH
K410‑ac EFRHLQLkEQkNAGt
K410‑ub EFRHLQLkEQkNAGt
K413‑ac HLQLkEQkNAGtRTN
T417‑p kEQkNAGtRTNEGPL
K511‑ub WQFSSVTkRGLNVDQ
K525‑ub QLNMLGEkLLGPNAs
S532‑p kLLGPNAsPDGLIPW
K544‑ub IPWTRFCkENINDKN
S583‑p GCIMGFIsKERERAL
K592‑ub ERERALLkDQQPGTF
K636‑ub HAVEPYTkKELsAVT
K637 AVEPYTkKELsAVTF
S640‑p PYTkKELsAVTFPDI
K652‑ub PDIIRNYkVMAAENI
K665‑ub NIPENPLkYLyPNID
Y668‑p ENPLkYLyPNIDKDH
K673 YLyPNIDKDHAFGKY
K679 DKDHAFGKYYSRPKE
T699‑p ELDGPKGtGyIktEL
Y701‑p DGPKGtGyIktELIs
K703‑sm PKGtGyIktELIsVS
T704‑p KGtGyIktELIsVSE
S708‑p yIktELIsVSEVHPS
T719 VHPSRLQTTDNLLPM
T720 HPSRLQTTDNLLPMs
S727‑p TDNLLPMsPEEFDEV
S735 PEEFDEVSRIVGSVE
S745 VGSVEFDSMMNTV__
N748 VEFDSMMNTV_____
5167 : Phospho-Stat1 (Tyr701) (58D6) Rabbit mAb (Sepharose Bead Conjugate)
5375 : Phospho-Stat1 (Tyr701) (58D6) Rabbit mAb (Biotinylated)
7649 : Phospho-Stat1 (Tyr701) (D4A7) Rabbit mAb
8009 : Phospho-Stat1 (Tyr701) (58D6) Rabbit mAb (Alexa Fluor(R) 647 Conjugate)
8062 : Phospho-Stat1 (Tyr701) (58D6) Rabbit mAb (PE Conjugate)
8183 : Phospho-Stat1 (Tyr701) (58D6) Rabbit mAb (Alexa Fluor(R) 555 Conjugate)
9167 : Phospho-Stat1 (Tyr701) (58D6) Rabbit mAb
9171 : Phospho-Stat1 (Tyr701) Antibody
9174 : Phospho-Stat1 (Tyr701) (58D6) Rabbit mAb (Alexa Fluor(R) 488 Conjugate)
8826 : Phospho-Stat1 (Ser727) (D3B7) Rabbit mAb
9177 : Phospho-Stat1 (Ser727) Antibody
  STAT1 iso2  
R31 DSFPMEIRQYLAQWL
R31 DSFPMEIRQYLAQWL
K40 YLAQWLEKQDWEHAA
Y68 LSQLDDQYSRFSLEN
Y106 IQMSMIIYSCLKEER
K138 QSTVMLDKQKELDSK
S162 CIEHEIKSLEDLQDE
Y170 LEDLQDEYDFKCKTL
K173 LQDEYDFKCKTLQNR
K173 LQDEYDFKCKTLQNR
T184 LQNREHETNGVAKSD
K193 GVAKSDQKQEQLLLK
Y203 QLLLKKMYLMLDNKR
K209 MYLMLDNKRKEVVHK
K216 KRKEVVHKIIELLNV
V223 KIIELLNVTELTQNA
T227 LLNVTELTQNALIND
K240 NDELVEWKRRQQSAC
K296 YEHDPITKNKQVLWD
K298 HDPITKNKQVLWDRT
K375 VNERNTVKGFRKFNI
K379 NTVKGFRKFNILGTH
K379 NTVKGFRKFNILGTH
K410 EFRHLQLKEQKNAGT
K410 EFRHLQLKEQKNAGT
K413 HLQLKEQKNAGTRTN
T417 KEQKNAGTRTNEGPL
K511 WQFSSVTKRGLNVDQ
K525 QLNMLGEKLLGPNAS
S532 KLLGPNASPDGLIPW
K544 IPWTRFCKENINDKN
S583 GCIMGFISKERERAL
K592 ERERALLKDQQPGTF
K636 HAVEPYTKKELSAVT
K637 AVEPYTKKELSAVTF
S640 PYTKKELSAVTFPDI
K652 PDIIRNYKVMAAENI
K665 NIPENPLKYLYPNID
Y668 ENPLKYLYPNIDKDH
K673 YLYPNIDKDHAFGKY
K679 DKDHAFGKYYSRPKE
T699 ELDGPKGTGYIKTEL
Y701 DGPKGTGYIKTELIS
K703 PKGTGYIKTELISVS
T704 KGTGYIKTELISVSE
S708 YIKTELISVSEV___
- gap
- gap
- gap
- gap
- gap
- gap
  rat

 
R31 DSFPMEIRQYLAQWL
R31 DSFPMEIRQYLAQWL
K40 YLAQWLEKQDWEHAA
Y68 LSQLDDQYSRFSLEN
H106 VQMSMIIHNCLKEER
K138 QNTVMLDKQKELDSK
T162 CIEHEIKTLEDLQDE
Y170 LEDLQDEYDFKCKTS
K173 LQDEYDFKCKTSQNR
K173 LQDEYDFKCKTSQNR
A184 SQNRESEANGVAKSD
K193 GVAKSDQKQEQLLLH
F203 QLLLHKMFLMLDNKR
K209 MFLMLDNKRKEIIHk
K216‑ac KRKEIIHkIRELLNs
S223‑p kIRELLNsIELtQNT
T227‑p LLNsIELtQNTLIND
K240 NDELVEWKRRQQSAC
K296 YEQDPITKNKQVLSD
K298 QDPITKNKQVLSDRT
K375 VNEKNTVKGFRkFNI
K379‑ac NTVKGFRkFNILGTH
K379 NTVKGFRKFNILGTH
K410‑ac EFRHLQLkEQKNAGN
K410 EFRHLQLKEQKNAGN
K413 HLQLkEQKNAGNRTN
N417 kEQKNAGNRTNEGPL
K511 WQFSSVTKRGLNADQ
K525 QLSMLGEKLLGPNAG
G532 KLLGPNAGPDGLIPW
K544 IPWTRFCKENINDKN
S583 GCIMGFISKERERAL
K592 ERERALLKDQQPGTF
K636 HAVEPYTKKELSAVT
K637 AVEPYTKKELSAVTF
S640 PYTKKELSAVTFPDI
K652 PDIIRNYKVMAAENI
K665 NIPENPLKYLYPNID
Y668 ENPLKYLYPNIDKDH
K673 YLYPNIDKDHAFGKY
K679 DKDHAFGKYYSRPKE
T699 ELDDPKRTGyIKTEL
Y701‑p DDPKRTGyIKTELIS
K703 PKRTGyIKTELISVS
T704 KRTGyIKTELISVSE
S708 yIKTELISVSEVHPS
S719‑p VHPSRLQsTENLLPM
T720 HPSRLQsTENLLPMs
S727‑p TENLLPMsPEEFDEM
S735 PEEFDEMSKIVGSEF
S744 IVGSEFDSMMSAV__
S747 SEFDSMMSAV_____
5167 : Phospho-Stat1 (Tyr701) (58D6) Rabbit mAb (Sepharose Bead Conjugate)
5375 : Phospho-Stat1 (Tyr701) (58D6) Rabbit mAb (Biotinylated)
7649 : Phospho-Stat1 (Tyr701) (D4A7) Rabbit mAb
8009 : Phospho-Stat1 (Tyr701) (58D6) Rabbit mAb (Alexa Fluor(R) 647 Conjugate)
8062 : Phospho-Stat1 (Tyr701) (58D6) Rabbit mAb (PE Conjugate)
8183 : Phospho-Stat1 (Tyr701) (58D6) Rabbit mAb (Alexa Fluor(R) 555 Conjugate)
9167 : Phospho-Stat1 (Tyr701) (58D6) Rabbit mAb
9171 : Phospho-Stat1 (Tyr701) Antibody
8826 : Phospho-Stat1 (Ser727) (D3B7) Rabbit mAb
9177 : Phospho-Stat1 (Ser727) Antibody
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