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Protein Page:
ENG (human)

Overview
ENG Major glycoprotein of vascular endothelium. May play a critical role in the binding of endothelial cells to integrins and/or other RGD receptors. Homodimer that forms an heteromeric complex with the signaling receptors for transforming growth factor-beta: TGFBR1 and/or TGFBR2. It is able to bind TGF-beta 1, and 3 efficiently and TGF-beta 2 less efficiently. Interacts with TCTEX1D4. Interacts with ARRB2. Endoglin is restricted to endothelial cells in all tissues except bone marrow. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Receptor, misc.; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 9q34.11
Cellular Component: cell surface; cytoplasm; external side of plasma membrane; extracellular space; focal adhesion; nucleoplasm; receptor complex
Molecular Function: activin binding; galactose binding; glycosaminoglycan binding; protein binding; protein homodimerization activity; punt binding; transforming growth factor beta binding; transforming growth factor beta receptor activity; transforming growth factor beta receptor, cytoplasmic mediator activity; transmembrane receptor activity
Biological Process: artery morphogenesis; BMP signaling pathway; cell adhesion; cell migration; cell motility involved in cell locomotion; central nervous system vasculogenesis; chronological cell aging; extracellular matrix disassembly; heart looping; negative regulation of cell migration; negative regulation of endothelial cell proliferation; negative regulation of nitric-oxide synthase activity; negative regulation of protein amino acid autophosphorylation; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transforming growth factor beta receptor signaling pathway; patterning of blood vessels; positive regulation of angiogenesis; positive regulation of BMP signaling pathway; positive regulation of protein amino acid phosphorylation; positive regulation of systemic arterial blood pressure; positive regulation of transcription from RNA polymerase II promoter; regulation of cell adhesion; regulation of cell proliferation; regulation of phosphorylation; regulation of transcription, DNA-dependent; regulation of transforming growth factor beta receptor signaling pathway; response to hypoxia; smooth muscle development; transforming growth factor beta receptor signaling pathway; vasculogenesis; venous blood vessel morphogenesis; wound healing
Disease: Telangiectasia, Hereditary Hemorrhagic, Of Rendu, Osler, And Weber
Reference #:  P17813 (UniProtKB)
Alt. Names/Synonyms: CD105; CD105 antigen; EGLN; END; Endoglin; ENG; FLJ41744; HHT1; ORW; ORW1
Gene Symbols: ENG
Molecular weight: 70,578 Da
Basal Isoelectric point: 6.14  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

ENG

Protein Structure Not Found.


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Sites Implicated In
cell motility, altered: S646‑p
phosphorylation: S634‑p, S635‑p

Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
1 0 Y612‑p LLTAALWyIySHTRS
1 0 Y614‑p TAALWyIySHTRSPS
1 1 S634‑p VAVAAPAssESSStN
1 1 S635‑p AVAAPAssESSStNH
1 0 T640‑p AssESSStNHSIGsT
1 0 S646‑p StNHSIGsTQstPCS
1 0 S649‑p HSIGsTQstPCStSS
2 0 T650‑p SIGsTQstPCStSSM
1 0 T654‑p TQstPCStSSMA___
  mouse

 
Y607 LLTAALWYIYSHTRG
Y609 TAALWYIYSHTRGPS
S629 VAVAAPASSESSSTN
S630 AVAAPASSESSSTNH
T635 ASSESSSTNHSIGST
S641 STNHSIGSTQSTPCS
S644 HSIGSTQSTPCSTSS
T645 SIGSTQSTPCSTSSM
T649 TQSTPCSTSSMA___
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