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Protein Page:
FosB (human)

Overview
FosB FosB interacts with Jun proteins enhancing their DNA binding activity. Heterodimer. Belongs to the bZIP family. Fos subfamily. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 19q13.32
Cellular Component: nucleus
Molecular Function: DNA binding; transcription factor binding
Biological Process: negative regulation of transcription from RNA polymerase II promoter
Reference #:  P53539 (UniProtKB)
Alt. Names/Synonyms: activator protein 1; AP-1; DKFZp686C0818; FBJ murine osteosarcoma viral oncogene homolog B; FOSB; G0/G1 switch regulatory protein 3; G0S3; GOS3; GOSB; MGC42291; oncogene FOS-B; Protein fosB
Gene Symbols: FOSB
Molecular weight: 35,928 Da
Basal Isoelectric point: 4.78  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

FosB

Protein Structure Not Found.


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Sites Implicated In
transcription, induced: S27‑p
activity, induced: S27‑p
protein stabilization: S27‑p

Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 Y9‑p FQAFPGDyDsGsRCS
0 1 S11‑p AFPGDyDsGsRCSSS
0 1 S13‑p PGDyDsGsRCSSSPS
4 0 S27‑p SAESQYLsSVDSFGS
1 0 T149 PRRPREETLtPEEEE
0 1 T151‑p RPREETLtPEEEEKR
1 0 T180 RNRRRELTDRLQAET
0 3 S321 FAGAQRTSGSDQPSD
0 3 G322 AGAQRTSGSDQPSDP
0 4 S332 QPSDPLNSPSLLAL_
0 2 S334 SDPLNSPSLLAL___
  mouse

 
Y9 FQAFPGDYDSGSRCS
S11 AFPGDYDSGSRCSSS
S13 PGDYDSGSRCSSSPS
S27‑p SAESQYLsSVDSFGS
T149‑p PRRPREEtLTPEEEE
T151 RPREEtLTPEEEEKR
T180‑p RNRRRELtDRLQAET
S321 FAGAQRTSGSEQPSD
G322 AGAQRTSGSEQPSDP
S332‑p QPSDPLNsPsLLAL_
S334‑p SDPLNsPsLLAL___
  rat

 
Y5 ___MYQDYPGNFDTS
T11 DYPGNFDTSSRGSSG
S13 PGNFDTSSRGSSGSP
- gap
- gap
S36 GGGGQQLSPEEEEKR
T65 RNRRRELTEKLQAET
S223‑p CSKAHRRssSSGDQS
S224‑p SKAHRRssSSGDQSS
S236‑p QSSDSLNsPtLLAL_
T238‑p SDSLNsPtLLAL___
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