Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteprivacy & cookiesCuration ProcessContact
logos LINCs Logo Mt Sinai Logo NIH Logo NCI Logo
Protein Page:
LIG1 (mouse)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
LIG1 is an enzyme that functions in DNA replication and the base excision repair process. Mutations leading to DNA ligase I deficiency result in immunodeficiency and increased sensitivity to DNA-damaging agents. Note: This description may include information from UniProtKB.
Protein type: Ligase; DNA repair, damage; EC 6.5.1.1
Cellular Component: Golgi apparatus; intracellular membrane-bound organelle; mitochondrion; nucleoplasm; nucleus
Molecular Function: DNA ligase (ATP) activity; DNA ligase activity
Biological Process: base-excision repair; DNA repair; DNA replication; double-strand break repair via nonhomologous end joining; response to hydrogen peroxide
Reference #:  P37913 (UniProtKB)
Alt. Names/Synonyms: AL033288; DNA ligase 1; DNA ligase I; DNLI1; Lig-1; Lig1; ligase I, DNA, ATP-dependent; LigI; Polydeoxyribonucleotide synthase [ATP] 1
Gene Symbols: Lig1
Molecular weight: 102,290 Da
Basal Isoelectric point: 6.43  Predict pI for various phosphorylation states
Select Structure to View Below

LIG1

Protein Structure Not Found.
Download PyMol Script
Download ChimeraX Script


STRING  |  Reactome  |  BioGPS  |  Scansite  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene


Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       mouse

► Hide Isoforms
 
0 1 - gap
0 1 S4 ____MQRSIMSFFQP
0 1 K16‑ac FQPTKEGkAKKPEKE
0 14 P47 KERNQVVPEsDsPVK
0 16 S49‑p RNQVVPEsDsPVKRT
3 53 S51‑p QVVPEsDsPVKRTGR
0 5 K59‑ub PVKRTGRkVAQVLsC
0 9 S65‑p RkVAQVLsCEGEDED
4 50 C66 kVAQVLsCEGEDEDE
6 51 G76 EDEDEAPGtPKVQKP
0 16 T77‑p DEDEAPGtPKVQKPV
0 2 S85‑p PKVQKPVsDSEQssP
0 1 S90‑p PVsDSEQssPPsPDt
3 9 S91‑p VsDSEQssPPsPDtC
0 1 S94‑p SEQssPPsPDtCPEN
0 2 T97‑p ssPPsPDtCPENsPV
0 1 C98 sPPsPDtCPENsPVF
0 2 S102‑p PDtCPENsPVFNCSS
0 1 S109 sPVFNCSSPMDIsPS
0 1 S114‑p CSSPMDIsPSGFPKR
0 39 N141 QDTLEEQNEDKTKTA
0 1 S161 EEETPKESLAEAEDI
0 6 A163 ETPKESLAEAEDIKQ
0 1 K169 LAEAEDIKQKEEKEG
0 4 I180 EKEGDQLIVPSEPtK
0 25 V181 KEGDQLIVPSEPtKs
0 2 T186‑p LIVPSEPtKsPEsVt
0 11 S188‑p VPSEPtKsPEsVtLt
0 1 S191‑p EPtKsPEsVtLtKTE
1 39 T193‑p tKsPEsVtLtKTENI
1 9 T195‑p sPEsVtLtKTENIPV
0 4 T197 EsVtLtKTENIPVCK
0 30 N199 VtLtKTENIPVCKAG
0 1 A205 ENIPVCKAGVKLKPQ
0 2 K218 PQEEEQSKPPARGAK
0 1 K218 PQEEEQSKPPARGAK
0 1 K225 KPPARGAKTLsSFFt
0 1 K225 KPPARGAKTLsSFFt
0 8 S228‑p ARGAKTLsSFFtPRK
0 3 S229 RGAKTLsSFFtPRKP
1 86 T232‑p KTLsSFFtPRKPAVK
0 1 K243 PAVKTEVKQEESGTL
0 1 T309 ARLKMVETLSNLLRS
0 1 S311 LKMVETLSNLLRSVV
0 3 K354‑ub VGDGVLLkAVAQATG
0 2 K374 IRAEVAEKGDVGLVA
0 2 K405 TISGVFTKFCDIARL
0 1 K420 TGSASMAKKMDIIKG
0 1 S435 LFVACRHSEARYIAR
0 1 S443 EARYIARSLSGRLRL
0 1 S445 RYIARSLSGRLRLGL
0 1 T504 QGMILKQTFCEVPDL
0 3 S533 LPEHCKLSPGVPLKP
0 1 K539 LSPGVPLKPMLAHPT
0 1 T546 KPMLAHPTRGVSEVL
0 1 S550 AHPTRGVSEVLKRFE
0 1 T593‑p SRNQEDNtGKYPDII
0 1 S601‑p GKYPDIIsRIPKIKH
0 1 K628 VAWDREKKQIQPFQV
0 7 T637 IQPFQVLTTRKRKEV
0 1 S712 IAEFLEQSVKDSCEG
0 1 T796 QAICKLGTGFSDEEL
0 9 S799 CKLGTGFSDEELEEH
0 6 T817 LQALVLPTPRPYVRI
0 1 Y821 VLPTPRPYVRIDGAV
0 1 K864 RGLVDKEKGISLRFP
0 1 Y895 SNQVASLYRKQSQIQ
0 1 S899 ASLYRKQSQIQNQQs
0 4 S906‑p SQIQNQQssDLDsDV
0 8 S907‑p QIQNQQssDLDsDVE
0 34 - gap
0 47 S911‑p QQssDLDsDVEDy__
0 1 - gap
0 3 Y916‑p LDsDVEDy_______
  LIG1 iso3  
K9‑ac RKKEQERkGETSAAN
S20 SAANMQRSIMSFFQP
K32 FQPTKEGKAKKPEKE
P63 KERNQVVPESDSPVK
S65 RNQVVPESDSPVKRT
S67 QVVPESDSPVKRTGR
K75 PVKRTGRKVAQVLSC
S81 RKVAQVLSCEGEDED
C82 KVAQVLSCEGEDEDE
G92 EDEDEAPGTPKVQKP
T93 DEDEAPGTPKVQKPV
S101 PKVQKPVSDSEQSSP
S106 PVSDSEQSSPPSPDT
S107 VSDSEQSSPPSPDTC
S110 SEQSSPPSPDTCPEN
T113 SSPPSPDTCPENSPV
C114 SPPSPDTCPENSPVF
S118 PDTCPENSPVFNCSS
S125 SPVFNCSSPMDISPS
S130 CSSPMDISPSGFPKR
N157 QDTLEEQNEDKTKTA
S177 EEETPKESLAEAEDV
A179 ETPKESLAEAEDVKQ
K185 LAEAEDVKQKEEKEG
I196 EKEGDQLIVPSEPTK
V197 KEGDQLIVPSEPTKS
T202 LIVPSEPTKSPESVT
S204 VPSEPTKSPESVTLT
S207 EPTKSPESVTLTKTE
T209 TKSPESVTLTKTENI
T211 SPESVTLTKTENIPV
T213 ESVTLTKTENIPVCK
N215 VTLTKTENIPVCKAG
A221 ENIPVCKAGVKLKPQ
K234 PQEEEQSKPPARGAK
K234 PQEEEQSKPPARGAK
K241 KPPARGAKTLSSFFT
K241 KPPARGAKTLSSFFT
S244 ARGAKTLSSFFTPRK
S245 RGAKTLSSFFTPRKP
T248 KTLSSFFTPRKPAVK
K259 PAVKTEVKQEESGTL
T325 ARLKMVETLSNLLRS
S327 LKMVETLSNLLRSVV
K370 VGDGVLLKAVAQATG
K390 IRAEVAEKGDVGLVA
K421 TISGVFTKFCDIARL
K436 TGSASMAKKMDIIKG
S451 LFVACRHSEARYIAR
S459 EARYIARSLSGRLRL
S461 RYIARSLSGRLRLGL
T520 QGMILKQTFCEVPDL
S549 LPEHCKLSPGVPLKP
K555 LSPGVPLKPMLAHPT
T562 KPMLAHPTRGVSEVL
S566 AHPTRGVSEVLKRFE
T609 SRNQEDNTGKYPDII
S617 GKYPDIISRIPKIKH
K644 VAWDREKKQIQPFQV
T653 IQPFQVLTTRKRKEV
S728 IAEFLEQSVKDSCEG
T812 QAICKLGTGFSDEEL
S815 CKLGTGFSDEELEEH
T833 LQALVLPTPRPYVRI
Y837 VLPTPRPYVRIDGAV
K880 RGLVDKEKGISLRFP
Y911 SNQVASLYRKQSQIQ
S915 ASLYRKQSQIQNQQS
S922 SQIQNQQSSDLDSDV
S923 QIQNQQSSDLDSDVE
- gap
S927 QQSSDLDSDVEDY__
- gap
Y932 LDSDVEDY_______
  human

 
- gap
S4‑p ____MQRsIMSFFHP
K16 FHPKKEGKAKKPEKE
S47‑p KEWNGVVsEsDsPVK
S49‑p WNGVVsEsDsPVKRP
S51‑p GVVsEsDsPVKRPGR
K59 PVKRPGRKAARVLGs
G65 RKAARVLGsEGEEED
S66‑p KAARVLGsEGEEEDE
S76‑p EEEDEALsPAKGQKP
P77 EEDEALsPAKGQKPA
L85 AKGQKPALDCSQVsP
V90 PALDCSQVsPPRPAt
S91‑p ALDCSQVsPPRPAts
R94 CSQVsPPRPAtsPEN
T97‑p VsPPRPAtsPENNAS
S98‑p sPPRPAtsPENNASL
N102 PAtsPENNASLSDTs
S109‑p NASLSDTsPMDSSPS
S114 DTsPMDSSPSGIPKR
S141‑p QEVLEEQsEDEDREA
S163‑p EEETPKEsLtEAEVA
T165‑p ETPKEsLtEAEVAtE
T171‑p LtEAEVAtEKEGEDG
T182‑p GEDGDQPttPPKPLK
T183‑p EDGDQPttPPKPLKt
L188 PttPPKPLKtSKAEt
T190‑p tPPKPLKtSKAEtPt
- gap
T195‑p LKtSKAEtPtEsVsE
T197‑p tSKAEtPtEsVsEPE
S199‑p KAEtPtEsVsEPEVA
S201‑p EtPtEsVsEPEVAtK
T207‑p VsEPEVAtKQELQEE
K219‑ac QEEEEQTkPPRRAPk
K219‑ub QEEEEQTkPPRRAPk
K226 kPPRRAPKTLssFFt
K226‑ub kPPRRAPkTLssFFt
S229‑p RRAPkTLssFFtPRK
S230‑p RAPkTLssFFtPRKP
T233‑p kTLssFFtPRKPAVK
K244‑sm PAVKKEVkEEEPGAP
T311‑p ARLRMVEtLsNLLRS
S313‑p LRMVEtLsNLLRSVV
K356 VGDGVLLKAVAQATG
K376‑ub VRAEAAEkGDVGLVA
K407‑ub TASGVFSkFRDIARL
K422‑ub TGSASTAkKIDIIKG
S437‑p LFVACRHsEARFIAR
S445‑p EARFIARsLsGRLRL
S447‑p RFIARsLsGRLRLGL
T506‑p QGMILKQtFCEVPDL
S535‑p LPEHCKLsPGIPLkP
K541‑ub LsPGIPLkPMLAHPt
T548‑p kPMLAHPtRGIsEVL
S552‑p AHPtRGIsEVLKRFE
T595 SRNQEDNTGKYPDII
S603 GKYPDIISRIPKIKL
K630‑sm VAWDREKkQIQPFQV
T639‑p IQPFQVLtTRKRKEV
S714‑p IAEFLEQsVKDSCEG
T798‑p QAICKLGtGFsDEEL
S801‑p CKLGtGFsDEELEEH
S819‑p LKALVLPsPRPyVRI
Y823‑p VLPsPRPyVRIDGAV
K866‑ub RGLVDSDkGISLRFP
Y897‑p SAQVACLyRKQsQIQ
S901‑p ACLyRKQsQIQNQQG
- gap
- gap
S911‑p QNQQGEDsGsDPEDt
S913‑p QQGEDsGsDPEDty_
T918‑p sGsDPEDty______
Y919‑p GsDPEDty_______
  rat

 
- gap
S4 ____MQRSIMSFFQP
K17 QPTTTEGKAKKPEKE
P48 KERNRAVPESDSPVK
S50 RNRAVPESDSPVKRP
S52 RAVPESDSPVKRPGR
K60 PVKRPGRKVAQVLss
S66‑p RKVAQVLssEGEDED
S67‑p KVAQVLssEGEDEDE
G77 EDEDEAPGtPQVQKP
T78‑p DEDEAPGtPQVQKPV
S86 PQVQKPVSDSKQSSP
S91 PVSDSKQSSPPSPDS
S92 VSDSKQSSPPSPDSC
S95 SKQSSPPSPDSCPEN
S98 SSPPSPDSCPENSPV
C99 SPPSPDSCPENSPVF
S103 PDSCPENSPVFNCSP
P110 SPVFNCSPSMDISPS
S115 CSPSMDISPSGFPKR
N142 QDTLEEPNEDKAKAV
S163 DPQTPPESLTEAEEV
T165 QTPPESLTEAEEVNQ
N171 LTEAEEVNQKEEQVE
T182 EQVEDQPTVPPEPTE
V183 QVEDQPTVPPEPTES
T188 PTVPPEPTESPESVT
S190 VPPEPTESPESVTLT
S193 EPTESPESVTLTKTE
T195 TESPESVTLTKTENI
T197 SPESVTLTKTENIPM
T199 ESVTLTKTENIPMCK
N201 VTLTKTENIPMCKAG
A207 ENIPMCKAGVKQKPQ
K220 PQEEEQSKPPARGAk
K220 PQEEEQSKPPARGAk
K227‑ac KPPARGAkPLSSFFT
K227 KPPARGAKPLSSFFT
S230 ARGAkPLSSFFTPRK
S231 RGAkPLSSFFTPRKP
T234 kPLSSFFTPRKPAVK
K245 PAVKTEVKQEESDTP
T311 ARLKMVETLSNLLRS
S313 LKMVETLSNLLRSVV
K356 VGDGVLLKAVAQATG
K376 IRAEVAEKGDVGLVA
K407 TVSGVFTKFCDIARL
K422 TGSASMAKKMDIIKG
S437 LFVACRYSEARFIAR
S445 EARFIARSLSGRLRL
S447 RFIARSLSGRLRLGL
T506 QGMILKQTFCEVPDL
S535 LPEHCKLSPGVPLKP
K541 LSPGVPLKPMLAHPT
T548 KPMLAHPTRGVREVL
R552 AHPTRGVREVLKRFE
S595 SRNQEDNSGKYPDII
S603 GKYPDIISRIPKIKH
K630 VAWDREKKQIQPFQV
T639 IQPFQVLTTRKRKEV
S714 IAEFLEQSVKDSCEG
T798 AAICKLGTGFSDEEL
S801 CKLGTGFSDEELEEH
T819 MQALLLPTPRPYVRI
Y823 LLPTPRPYVRIDGAV
K866 RGMVDKEKGISLRFP
Y897 SDQVASLYRKQSQIQ
S901 ASLYRKQSQIQNQQS
S908 SQIQNQQSSDLDsDV
S909 QIQNQQSSDLDsDVE
- gap
S913‑p QQSSDLDsDVEDY__
- gap
Y918 LDsDVEDY_______
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.