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Protein Page:
OCRL (human)
rdtyret
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
OCRL Converts phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol 4-phosphate. Also converts inositol 1,4,5- trisphosphate to inositol 1,4-bisphosphate and inositol 1,3,4,5- tetrakisphosphate to inositol 1,3,4-trisphosphate. May function in lysosomal membrane trafficking by regulating the specific pool of phosphatidylinositol 4,5-bisphosphate that is associated with lysosomes. Belongs to the inositol-1,4,5-trisphosphate 5- phosphatase type II family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Phosphatase (non-protein); EC 3.1.3.36; Motility/polarity/chemotaxis; Carbohydrate Metabolism - inositol phosphate
Chromosomal Location of Human Ortholog: Xq25
Cellular Component: clathrin-coated vesicle; coated pit; cytoplasm; cytosol; early endosome; early endosome membrane; Golgi stack; Golgi-associated vesicle; nucleus; phagocytic vesicle membrane; photoreceptor outer segment; plasma membrane; trans-Golgi network
Molecular Function: GTPase activator activity; phosphoinositide 5-phosphatase activity; protein binding; Rac GTPase binding
Biological Process: cilium biogenesis; in utero embryonic development; inositol phosphate metabolic process; lipid metabolic process; phosphatidylinositol biosynthetic process; phosphoinositide dephosphorylation; phospholipid metabolic process; positive regulation of GTPase activity; regulation of GTPase activity; regulation of small GTPase mediated signal transduction; small GTPase mediated signal transduction
Disease: Dent Disease 2; Lowe Oculocerebrorenal Syndrome
Reference #:  Q01968 (UniProtKB)
Alt. Names/Synonyms: Inositol polyphosphate 5-phosphatase OCRL-1; INPP5F; LOCR; Lowe oculocerebrorenal syndrome protein; NPHL2; OCRL; OCRL1; oculocerebrorenal syndrome of Lowe; phosphatidylinositol polyphosphate 5-phosphatase
Gene Symbols: OCRL
Molecular weight: 104,205 Da
Basal Isoelectric point: 6.13  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

OCRL

Protein Structure Not Found.


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Modification Sites and Domains  
Click here to view other types of protein modifications

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 K127‑ub QLLVPEQkDSSSWyQ
0 31 Y133‑p QkDSSSWyQKLDtKD
0 1 T138‑p SWyQKLDtKDKPSVF
0 1 S183‑p EPPPPPFsVNKMLPR
0 1 Y234‑p LAKREKEyVNIQTFR
0 2 T346‑p IATETVGtGIMGKMG
0 2 Y390‑p FERRNQDyKDICARM
0 1 T405 SFVVPNQTLPQLNIM
0 2 K449‑ub KDLQRLLkFDQLNIQ
0 1 K461‑ub NIQRTQKkAFVDFNE
0 1 S528‑p TSDHKPVsALFHIGV
0 1 K578‑ub EFVFENVkFRQLQKE
0 1 K701 IREVPVTKLIDLEED
0 1 S709‑p LIDLEEDsFLEKEKs
0 1 S716‑p sFLEKEKsLLQMVPL
0 11 T880‑p PNLMARQtPsDRQRA
0 11 S882‑p LMARQtPsDRQRAIQ
  OCRL iso2  
K127 QLLVPEQKDSSSWYQ
Y133 QKDSSSWYQKLDTKD
T138 SWYQKLDTKDKPSVF
S183 EPPPPPFSVNKMLPR
Y234 LAKREKEYVNIQTFR
T346 IATETVGTGIMGKMG
Y390 FERRNQDYKDICARM
T405 SFVVPNQTLPQLNIM
K449 KDLQRLLKFDQLNIQ
K461 NIQRTQKKAFVDFNE
S528 TSDHKPVSALFHIGV
K578 EFVFENVKFRQLQKE
K701‑ub IREVPVTkLIDLEKS
- gap
S708 kLIDLEKSLLQMVPL
T872 PNLMARQTPSDRQRA
S874 LMARQTPSDRQRAIQ
  mouse

 
K127 QLLVPEQKDSSSWyQ
Y133‑p QKDSSSWyQKLDTMD
T138 SWyQKLDTMDKPAYS
S182 EPPPPPSSSTRMLSR
Y233 LTKREKEYVNIQSFR
T345 VATETTGTGIMGKMG
Y389 FERRNQDYKDICARM
T404‑p TFSVPNQtVPQVNIM
K448‑ub NELHKLLkFDQLNIQ
K460 NIQRTQKKAFADFNE
S527 TSDHKPVSALFHIGV
K577 EFFFENVKFRQLQKE
K700 IREVPVTKLIDLEED
S708 LIDLEEDSYLEKEKS
S715 SYLEKEKSLLQMVPL
T879 PNLMTRQTPNDRQHA
N881 LMTRQTPNDRQHAIQ
  rat

 
K127 QLLVPEQKDSSNWYQ
Y133 QKDSSNWYQKLDTKD
T138 NWYQKLDTKDKPAYS
S181 REPPPPPSSNRMLPR
Y232 LAKREKEYVNIQSFR
T344 IATETVGTGIMGKMG
Y388 FERRNQDYKDICARM
T403 SFSVPNQTLPQVNIM
K447 NELQKLLKFDQLNIQ
K459 NIQRTQKKAFVDFNE
S526 TSDHKPVSALFHIGV
K576 EFMFENVKFRQLQKE
K699 IREVPVTKLIDLEED
S707 LIDLEEDSFLEKEKS
S714 SFLEKEKSLLQMVPL
T878 PNLMARQTPSDRQRA
S880 LMARQTPSDRQRAIQ
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