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Protein Page:
ATG4C (human)

Overview
ATG4C Cysteine protease required for autophagy, which cleaves the C-terminal part of either MAP1LC3, GABARAPL2 or GABARAP, allowing the liberation of form I. A subpopulation of form I is subsequently converted to a smaller form (form II). Form II, with a revealed C-terminal glycine, is considered to be the phosphatidylethanolamine (PE)-conjugated form, and has the capacity for the binding to autophagosomes. Highly expressed in skeletal muscle, heart, liver and testis. Inhibited by N-ethylmaleimide. Belongs to the peptidase C54 family. Note: This description may include information from UniProtKB.
Protein type: Ubiquitin conjugating system; Protease; Autophagy; EC 3.4.22.-
Chromosomal Location of Human Ortholog: 1p31.3
Cellular Component: cytoplasm; cytosol; extracellular region
Molecular Function: cysteine-type endopeptidase activity; peptidase activity
Biological Process: autophagic vacuole formation; autophagy; C-terminal protein lipidation; mitochondrion degradation; protein delipidation; protein processing; protein targeting to membrane; proteolysis
Reference #:  Q96DT6 (UniProtKB)
Alt. Names/Synonyms: APG4 autophagy 4 homolog C; APG4-C; APG4C; ATG4 autophagy related 4 homolog C (S. cerevisiae); ATG4C; AUT-like 1, cysteine endopeptidase; AUT-like 3 cysteine endopeptidase; AUTL1; AUTL3; Autophagin-3; Autophagy-related cysteine endopeptidase 3; Autophagy-related protein 4 homolog C; Cysteine protease ATG4C; FLJ14867
Gene Symbols: ATG4C
Molecular weight: 52,497 Da
Basal Isoelectric point: 5.65  Predict pI for various phosphorylation states
CST Pathways:  Autophagy Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

ATG4C

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S18‑p KLKTKFIsAWNNMKy
0 1 Y25‑p sAWNNMKySWVLKTK
0 1 T173 SGEREFKTPTISLKE
0 1 S177 EFKTPTISLKEtIGK
0 2 T181‑p PTISLKEtIGKysDD
0 1 Y185‑p LKEtIGKysDDHEMR
0 1 S186‑p KEtIGKysDDHEMRN
0 3 S369‑p LETFHCPsPKKMSFR
0 2 S381‑p SFRKMDPsCtIGFyC
0 1 T383‑p RKMDPsCtIGFyCRN
0 2 Y387‑p PsCtIGFyCRNVQDF
0 1 N434 DFTSTTTNEEDLFSE
0 5 S451‑p KKQLKRFstEEFVLL
0 7 T452‑p KQLKRFstEEFVLL_
  mouse

 
S18 KLKTKFISAWNNMKY
Y25 SAWNNMKYSWVLKTK
T173‑p SGDRELRtPAVsLKE
S177‑p ELRtPAVsLKEtSGK
T181‑p PAVsLKEtSGKCPDD
C185 LKEtSGKCPDDHAVR
P186 KEtSGKCPDDHAVRN
S369‑p LETFHCPsPKKMSFR
S381 SFRKMDPSCTIGFYC
T383 RKMDPSCTIGFYCRN
Y387 PSCTIGFYCRNVQDF
S434‑p DFTSTAAsEEDLFSE
S451 RKNFKRFSTEEFVLL
T452 KNFKRFSTEEFVLL_
  rat

 
S18 KLKTKFISAWNNMKY
Y25 SAWNNMKYSWVLKTK
T173 SGERELRTPAVSLKE
S177 ELRTPAVSLKETSGK
T181 PAVSLKETSGKHPDD
H185 LKETSGKHPDDHAVQ
P186 KETSGKHPDDHAVQS
S369 LETFHCPSPKKMSFR
S381 SFRKMDPSCTIGFYC
T383 RKMDPSCTIGFYCRN
Y387 PSCTIGFYCRNVQDF
S434 DFTSTAASEEDLFLE
S451 KKNFKRFSTEEFVLL
T452 KNFKRFSTEEFVLL_
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