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Protein Page:
ATG4C (human)

Overview
ATG4C Cysteine protease required for autophagy, which cleaves the C-terminal part of either MAP1LC3, GABARAPL2 or GABARAP, allowing the liberation of form I. A subpopulation of form I is subsequently converted to a smaller form (form II). Form II, with a revealed C-terminal glycine, is considered to be the phosphatidylethanolamine (PE)-conjugated form, and has the capacity for the binding to autophagosomes. Highly expressed in skeletal muscle, heart, liver and testis. Inhibited by N-ethylmaleimide. Belongs to the peptidase C54 family. Note: This description may include information from UniProtKB.
Protein type: Protease; Autophagy; EC 3.4.22.-; Ubiquitin conjugating system
Chromosomal Location of Human Ortholog: 1p31.3
Cellular Component: cytoplasm; cytosol; extracellular region
Molecular Function: cysteine-type endopeptidase activity; peptidase activity
Biological Process: autophagic vacuole formation; autophagy; C-terminal protein lipidation; mitochondrion degradation; protein delipidation; protein processing; protein targeting to membrane; proteolysis
Reference #:  Q96DT6 (UniProtKB)
Alt. Names/Synonyms: APG4 autophagy 4 homolog C; APG4-C; APG4C; ATG4 autophagy related 4 homolog C (S. cerevisiae); ATG4C; AUT-like 1, cysteine endopeptidase; AUT-like 3 cysteine endopeptidase; AUTL1; AUTL3; Autophagin-3; Autophagy-related cysteine endopeptidase 3; Autophagy-related protein 4 homolog C; Cysteine protease ATG4C; FLJ14867
Gene Symbols: ATG4C
Molecular weight: 52,497 Da
Basal Isoelectric point: 5.65  Predict pI for various phosphorylation states
CST Pathways:  Autophagy Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

ATG4C

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S18‑p KLKTKFIsAWNNMKy
0 1 Y25‑p sAWNNMKySWVLKTK
0 1 S164‑p FTASFEAsLsGEREF
0 1 S166‑p ASFEAsLsGEREFKT
0 1 T173 sGEREFKTPTISLKE
0 1 S177 EFKTPTISLKEtIGK
0 2 T181‑p PTISLKEtIGKysDD
0 1 Y185‑p LKEtIGKysDDHEMR
0 1 S186‑p KEtIGKysDDHEMRN
0 3 S369‑p LETFHCPsPKKMSFR
0 2 S381‑p SFRKMDPsCtIGFyC
0 1 T383‑p RKMDPsCtIGFyCRN
0 2 Y387‑p PsCtIGFyCRNVQDF
0 1 N434 DFTSTTTNEEDLFSE
0 5 S451‑p KKQLKRFstEEFVLL
0 7 T452‑p KQLKRFstEEFVLL_
  mouse

 
S18 KLKTKFISAWNNMKY
Y25 SAWNNMKYSWVLKTK
S164 FTASFEASLSGDREL
S166 ASFEASLSGDRELRt
T173‑p SGDRELRtPAVsLKE
S177‑p ELRtPAVsLKEtSGK
T181‑p PAVsLKEtSGKCPDD
C185 LKEtSGKCPDDHAVR
P186 KEtSGKCPDDHAVRN
S369‑p LETFHCPsPKKMSFR
S381 SFRKMDPSCTIGFYC
T383 RKMDPSCTIGFYCRN
Y387 PSCTIGFYCRNVQDF
S434‑p DFTSTAAsEEDLFSE
S451 RKNFKRFSTEEFVLL
T452 KNFKRFSTEEFVLL_
  rat

 
S18 KLKTKFISAWNNMKY
Y25 SAWNNMKYSWVLKTK
S164 FTASFEASLSGEREL
S166 ASFEASLSGERELRT
T173 SGERELRTPAVSLKE
S177 ELRTPAVSLKETSGK
T181 PAVSLKETSGKHPDD
H185 LKETSGKHPDDHAVQ
P186 KETSGKHPDDHAVQS
S369 LETFHCPSPKKMSFR
S381 SFRKMDPSCTIGFYC
T383 RKMDPSCTIGFYCRN
Y387 PSCTIGFYCRNVQDF
S434 DFTSTAASEEDLFLE
S451 KKNFKRFSTEEFVLL
T452 KNFKRFSTEEFVLL_
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