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Protein Page:
MEIS1 (human)

MEIS1 Acts as a transcriptional regulator of PAX6. Acts as a transcriptional activator of PF4 in complex with PBX1 or PBX2. Required for hematopoiesis, megakaryocyte lineage development and vascular patterning. May function as a cofactor for HOXA7 and HOXA9 in the induction of myeloid leukemias. Defects in MEIS1 could be a cause of susceptibility to restless legs syndrome type 7 (RLS7). Restless legs syndrome (RLS) is a neurologic sleep/wake disorder characterized by uncomfortable and unpleasant sensations in the legs that appear at rest, usually at night, inducing an irresistible desire to move the legs. The disorder results in nocturnal insomnia and chronic sleep deprivation. Belongs to the TALE/MEIS homeobox family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: DNA-binding
Chromosomal Location of Human Ortholog: 2p14
Molecular Function: protein binding
Biological Process: negative regulation of myeloid cell differentiation
Disease: Restless Legs Syndrome, Susceptibility To, 7
Reference #:  O00470 (UniProtKB)
Alt. Names/Synonyms: Homeobox protein Meis1; Meis homeobox 1; MEIS1; myeloid ecotropic viral integration site 1
Gene Symbols: MEIS1
Molecular weight: 43,016 Da
Basal Isoelectric point: 5.86  Predict pI for various phosphorylation states
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