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Protein Page:
STIM2 (human)

Overview
STIM2 Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Functions as a highly sensitive Ca(2+) sensor in the endoplasmic reticulum which activates both store-operated and store-independent Ca(2+)-influx. Regulates basal cytosolic and endoplasmic reticulum Ca(2+) concentrations. Upon mild variations of the endoplasmic reticulum Ca(2+) concentration, translocates from the endoplasmic reticulum to the plasma membrane where it probably activates the Ca(2+) release-activated Ca(2+) (CRAC) channels ORAI1, ORAI2 and ORAI3. May inhibit STIM1-mediated Ca(2+) influx. Oligomer with STIM1. Interacts with ORAI1. Expressed in all tissues and tumor cell lines examined. Note: This description may include information from UniProtKB.
Protein type: Cell adhesion; Membrane protein, integral
Chromosomal Location of Human Ortholog: 4p15.2
Cellular Component: endoplasmic reticulum; plasma membrane
Molecular Function: calcium channel regulator activity; calcium ion binding; protein binding; store-operated calcium channel activity
Biological Process: activation of store-operated calcium channel activity; cellular calcium ion homeostasis; positive regulation of calcium ion transport
Reference #:  Q9P246 (UniProtKB)
Alt. Names/Synonyms: FLJ39527; KIAA1482; STIM2; Stromal interaction molecule 2
Gene Symbols: STIM2
Molecular weight: 83,971 Da
Basal Isoelectric point: 6.3  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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STIM2

Protein Structure Not Found.
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