Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
logos LINCs Logo Mt Sinai Logo NIH Logo NCI Logo
Protein Page:
ATG7 (human)
rdtyret
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
ATG7 Functions as an E1 enzyme essential for multisubstrates such as ATG8-like proteins and ATG12. Forms intermediate conjugates with ATG8-like proteins (GABARAP, GABARAPL1, GABARAPL2 or MAP1LC3A). PE-conjugation to ATG8-like proteins is essential for autophagy. Also acts as an E1 enzyme for ATG12 conjugation to ATG5 and ATG3. Homodimer. Interacts with ATG3 and ATG12. The complex, composed of ATG3 and ATG7, plays a role in the conjugation of ATG12 to ATG5. Widely expressed, especially in kidney, liver, lymph nodes and bone marrow. Belongs to the ATG7 family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Autophagy; Ubiquitin conjugating system
Chromosomal Location of Human Ortholog: 3p25.3
Cellular Component: axoneme; cytoplasm; cytosol
Molecular Function: APG12 activating enzyme activity; APG8 activating enzyme activity; protein binding; protein homodimerization activity; transcription factor binding; ubiquitin activating enzyme activity
Biological Process: adult walking behavior; amino acid metabolic process; C-terminal protein lipidation; cardiac muscle cell development; cellular response to nitrogen starvation; cellular response to starvation; central nervous system neuron axonogenesis; cerebellar Purkinje cell layer development; cerebral cortex development; defense response to virus; liver development; macroautophagy; mitochondrion degradation; negative regulation of apoptosis; neurological system process; positive regulation of apoptosis; positive regulation of autophagy; positive regulation of macroautophagy; positive regulation of protein catabolic process; positive regulation of protein modification process; post-embryonic development; protein amino acid lipidation; protein catabolic process; protein modification process; protein transport; protein ubiquitination; pyramidal neuron development; regulation of protein ubiquitination
Reference #:  O95352 (UniProtKB)
Alt. Names/Synonyms: APG7 autophagy 7-like; APG7-like; APG7L; ATG7; ATG7 autophagy related 7 homolog (S. cerevisiae); Autophagy-related protein 7; DKFZp434N0735; GSA7; hAGP7; ubiquitin activating enzyme E1-like protein; Ubiquitin-activating enzyme E1-like protein
Gene Symbols: ATG7
Molecular weight: 77,960 Da
Basal Isoelectric point: 5.85  Predict pI for various phosphorylation states
CST Pathways:  Autophagy Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

ATG7

Protein Structure Not Found.


STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Scansite  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene  |  InnateDB


Modification Sites and Domains  
Click here to view other types of protein modifications

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 T5‑p ___MAAAtGDPGLsK
0 1 S11‑p AtGDPGLsKLQFAPF
0 1 Y38‑p TQKKLNEyRLDEAPK
0 1 S295 KLPEMAFSPDCPKAV
0 1 K306‑ac PKAVGWEkNQKGGMG
0 1 K352‑ub VPTLDLDkVVSVKCL
0 1 K423 AAADRLQKIFPGVNA
0 1 S480 LLMDTRESRWLPAVI
0 2 S490‑p LPAVIAAsKRKLVIN
0 3 S698‑p AAEIWDMsDDETI__
0 1 T702 WDMsDDETI______
  ATG7 iso3  
T5 ___MAAATGDPGLSK
S11 ATGDPGLSKLQFAPF
Y38 TQKKLNEYRLDEAPK
S256 KLPEMAFSPDCPKAV
K267 PKAVGWEKNQKGGMG
K313 VPTLDLDKVVSVKCL
K384 AAADRLQKIFPGVNA
S441 LLMDTRESRWLPAVI
S451 LPAVIAASKRKLVIN
S618‑p SSKIWDMsDDEtI__
T622‑p WDMsDDEtI______
  mouse

 
M1 _______MGDPGLAK
A7 _MGDPGLAKLQFAPF
Y34 TQKKLNEYRLDEAPK
S291‑p KLPEMAFsPDCPKAV
K302 PKAVGWEKNQKGGMG
K348 VPTLDLDKVVSVKCL
K419‑ub AAAERLQkIFPGVNA
S476‑p LLMDTREsRWLPTVI
S486‑p LPTVIAAsKRKLVIN
S693 AAEIWDMSDEETV__
T697 WDMSDEETV______
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.