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Protein Page:
CREB (human)

Overview
CREB a transcription factor of the leucine zipper family of DNA binding proteins. Binds as a homodimer to the cAMP-responsive element (CRE). Phosphorylated by several protein kinases, and induces transcription of genes in response to hormonal stimulation of the cAMP pathway. Two splice-variant isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 2q34
Cellular Component: nucleoplasm; nucleus
Molecular Function: enzyme binding; protein binding; RNA polymerase II transcription factor activity, enhancer binding; transcription cofactor activity; transcription factor activity
Biological Process: axon guidance; circadian rhythm; positive regulation of fat cell differentiation; positive regulation of lipid biosynthetic process; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; protein amino acid phosphorylation; protein stabilization; response to glucagon stimulus; response to organic substance; signal transduction
Disease: Histiocytoma, Angiomatoid Fibrous
Reference #:  P16220 (UniProtKB)
Alt. Names/Synonyms: active transcription factor CREB; cAMP responsive element binding protein 1; cAMP-response element-binding protein-1; cAMP-responsive element-binding protein 1; CREB; CREB-1; CREB1; Cyclic AMP-responsive element-binding protein 1; MGC9284; transactivator protein
Gene Symbols: CREB1
Molecular weight: 36,688 Da
Basal Isoelectric point: 5.46  Predict pI for various phosphorylation states
CST Pathways:  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  Growth And Differentiation Control by MAPKs  |  Inhibition of Apoptosis  |  Parkinson's Disease  |  Regulation of P38 MAPKs  |  T Cell Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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CREB

Protein Structure Not Found.
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