a transcription factor of the leucine zipper family of DNA binding proteins. Binds as a homodimer to the cAMP-responsive element (CRE). Phosphorylated by several protein kinases, and induces transcription of genes in response to hormonal stimulation of the cAMP pathway. Two splice-variant isoforms have been described. Note: This description may include information from UniProtKB.
Molecular Function: enzyme binding; identical protein binding; protein binding; RNA polymerase II transcription factor activity, enhancer binding; transcription cofactor activity; transcription factor activity
Biological Process: axon guidance; circadian rhythm; positive regulation of fat cell differentiation; positive regulation of lipid biosynthetic process; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; protein amino acid phosphorylation; protein stabilization; response to glucagon stimulus; response to organic substance; signal transduction
Alt. Names/Synonyms: active transcription factor CREB; cAMP responsive element binding protein 1; cAMP-response element-binding protein-1; cAMP-responsive element-binding protein 1; CREB; CREB-1; CREB1; Cyclic AMP-responsive element-binding protein 1; MGC9284; transactivator protein