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Protein Page:
beclin 1 (human)
rdtyret
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
beclin 1 an essential autophagy protein that has been linked to multiple processes including tumor suppression, protection against some cardiac and neurological degenerative diseases, and lifespan extension. A ubiquitous protein of the beclin family. Is part of the class III PI3K complex that induces autophagy. Expressed at elevated levels in dendrites and cell bodies of cerebellar Purkinje cells. Interacts with the anti-apoptotic protein Bcl-2, which inhibits autophagy when it is present in the endoplasmic reticulum. The dissociation of ATG6 from Bcl-2 is essential for its autophagic activity. Interacts with PITC and GluR-delta2. Probably forms a complex with AMBRA1 and PIK3C3. Plays a role in antiviral host defense. Protects against infection by a neurovirulent strain of Sindbis virus. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, peripheral; Adaptor/scaffold; Autophagy
Chromosomal Location of Human Ortholog: 17q21
Cellular Component: autophagic vacuole; cytoplasmic membrane-bound vesicle; cytosol; dendrite; endoplasmic reticulum; endoplasmic reticulum membrane; endosome; endosome membrane; extrinsic to membrane; mitochondrial membrane; mitochondrion; nucleus; phagocytic vesicle; trans-Golgi network
Molecular Function: phosphoinositide 3-kinase binding; protein binding; ubiquitin protein ligase binding
Biological Process: apoptosis; autophagic vacuole formation; autophagy; beta-amyloid metabolic process; cellular defense response; cellular response to glucose starvation; cellular response to nitrogen starvation; CVT pathway; cytokinesis; defense response to virus; engulfment of apoptotic cell; late endosome to vacuole transport; lysosome organization and biogenesis; macroautophagy; mitotic metaphase plate congression; negative regulation of apoptosis; negative regulation of cell proliferation; neuron development; positive regulation of autophagy; positive regulation of phosphoinositide 3-kinase cascade; receptor catabolic process; regulation of catalytic activity; regulation of cytokinesis; response to drug; response to hypoxia; response to vitamin E; viral reproduction
Reference #:  Q14457 (UniProtKB)
Alt. Names/Synonyms: ATG6; ATG6 autophagy related 6 homolog; beclin 1 (coiled-coil, moesin-like BCL2 interacting protein); beclin 1 (coiled-coil, moesin-like BCL2-interacting protein); beclin 1, autophagy related; Beclin-1; beclin1; BECN1; Coiled-coil myosin-like BCL2-interacting protein; GT197; Protein GT197; VPS30
Gene Symbols: BECN1
Molecular weight: 51,896 Da
Basal Isoelectric point: 4.83  Predict pI for various phosphorylation states
CST Pathways:  Autophagy Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

beclin 1

Protein Structure Not Found.


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Sites Implicated In
apoptosis, induced: S90‑p
apoptosis, inhibited: S234‑p, S295‑p
autophagy, induced: S90‑p
autophagy, inhibited: K430‑ub, K437‑ub
carcinogenesis, induced: S234‑p, S295‑p
carcinogenesis, inhibited: S90‑p
cell growth, induced: K430‑ub, K437‑ub
cell growth, inhibited: S90‑p
acetylation: K430‑ub, K437‑ub
activity, induced: T119‑p
molecular association, regulation: S90‑p, T119‑p, S234‑p, S295‑p, K430‑ub, K437‑ub

Modification Sites and Domains  
Click here to view other types of protein modifications

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
2 0 S15‑p NNSTMQVsFVCQRCS
1 2 S30‑p QPLKLDTsFkILDRV
0 1 K32‑ub LKLDTsFkILDRVtI
0 1 T38‑p FkILDRVtIQELTAP
0 1 T57‑p AQAKPGEtQEEETNs
0 4 S64‑p tQEEETNsGEEPFIE
2 12 S90‑p IPPARMMstEsANsF
0 6 T91‑p PPARMMstEsANsFT
2 2 S93‑p ARMMstEsANsFTLI
2 2 S96‑p MstEsANsFTLIGEA
0 1 S104 FTLIGEASDGGtMEN
1 0 T108‑p GEASDGGtMENLSRR
1 0 K117‑ub ENLSRRLkVtGDLFD
2 0 T119‑p LSRRLkVtGDLFDIM
0 1 S177 EQMNEDDSEQLQMEL
0 1 K185 EQLQMELKELALEEE
0 1 K206‑ac EDVEKNRkIVAENLE
1 0 Y229‑p LDQEEAQyQREysEF
1 0 Y233‑p EAQyQREysEFKRQQ
1 0 S234‑p AQyQREysEFKRQQL
1 0 S279‑p ATFHIWHsGQFGTIN
1 0 S295‑p FRLGRLPsVPVEWNE
1 0 S337‑p LVPYGNHsYLESLTD
1 0 Y352‑p KSKELPLyCSGGLRF
0 1 K402‑ub RMDVEKGkIEDtGGs
1 1 T406‑p EKGkIEDtGGsGGSY
1 1 S409‑p kIEDtGGsGGSYSIK
1 2 K430‑ub EQWTKALkFMLTNLk
1 1 K437‑ub kFMLTNLkWGLAWVS
13825 : Phospho-Beclin-1 (Ser15) Antibody
84966 : Phospho-Beclin-1 (Ser15) (D4B7R) Rabbit mAb
12476 : Phospho-Beclin-1 (Ser93/96) Antibody
14717 : Phospho-Beclin-1 (Ser93) (D9A5G) Rabbit mAb
12476 : Phospho-Beclin-1 (Ser93/96) Antibody
  mouse

 
S14‑p SSSTMQVsFVCQRCS
S29 QPLKLDTSFKILDRV
K31 LKLDTSFKILDRVTI
T37 FKILDRVTIQELTAP
T56 AQAKPGETQEEEANS
S63 TQEEEANSGEEPFIE
S88‑p IPPARMMsTESANSF
T89 PPARMMsTESANSFT
S91 ARMMsTESANSFTLI
S94 MsTESANSFTLIGEA
S102‑p FTLIGEAsDGGTMEN
T106 GEAsDGGTMENLSRR
K115 ENLSRRLKVTGDLFD
T117 LSRRLKVTGDLFDIM
S175‑p EQMNEDDsEQLQREL
K183 EQLQRELKELALEEE
K204 EDVEKNRKVVAENLE
Y227 LDQEEAQYQREYSEF
Y231 EAQYQREYSEFKRQQ
S232 AQYQREYSEFKRQQL
S277 ATFHIWHSGQFGTIN
S293 FRLGRLPSVPVEWNE
S335 LVPYGNHSYLESLTD
Y350 KSKELPLYCSGGLRF
K400 RMDVEKGKIEDTGGS
T404 EKGKIEDTGGSGGSY
S407 KIEDTGGSGGSYSIK
K428‑ub EQWTKALkFMLTNLK
K435 kFMLTNLKWGLAWVS
13825 : Phospho-Beclin-1 (Ser15) Antibody
84966 : Phospho-Beclin-1 (Ser15) (D4B7R) Rabbit mAb
12476 : Phospho-Beclin-1 (Ser93/96) Antibody
14717 : Phospho-Beclin-1 (Ser93) (D9A5G) Rabbit mAb
12476 : Phospho-Beclin-1 (Ser93/96) Antibody
  rat

 
S14 SSSTMQVSFVCQRCS
S29 QPLKLDTSFKILDRV
K31 LKLDTSFKILDRVTI
T37 FKILDRVTIQELTAP
S56 AQAKPGESQEEEANS
S63 SQEEEANSGEEPFIE
S88 IPPARMMSTESANSF
T89 PPARMMSTESANSFT
S91 ARMMSTESANSFTLI
S94 MSTESANSFTLIGEA
S102 FTLIGEASDGGTMEN
T106 GEASDGGTMENLSRR
K115 ENLSRRLKVTGDLFD
T117 LSRRLKVTGDLFDIM
S175 EQMNEGDSEQLQREL
K183‑ac EQLQRELkELALEEE
K204 EDVEKNRKVVAENLE
Y227 LDQEEAQYQREYsEF
Y231 EAQYQREYsEFKRQQ
S232‑p AQYQREYsEFKRQQL
S277 ATFHIWHSGQFGTIN
S293‑p FRLGRLPsAPVEWNE
S335 LVPYGNHSYLESLTD
Y350 KSKELPLYCSGGLRF
K400 RMDVEKGKIEDTGGS
T404 EKGKIEDTGGSGGSY
S407 KIEDTGGSGGSYSIK
K428 EQWTKALKFMLTNLK
K435 KFMLTNLKWGLAWVS
12476 : Phospho-Beclin-1 (Ser93/96) Antibody
14717 : Phospho-Beclin-1 (Ser93) (D9A5G) Rabbit mAb
12476 : Phospho-Beclin-1 (Ser93/96) Antibody
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